STRINGSTRING
EGF EGF ENSVURP00010013703 ENSVURP00010013703 ENSVURP00010013335 ENSVURP00010013335 GAB1 GAB1 FGFR1 FGFR1 AREG AREG EREG EREG EPGN EPGN FNBP4 FNBP4 HBEGF HBEGF NRG2 NRG2 FGF1 FGF1 PPP2R1A PPP2R1A PIK3CB PIK3CB MAPK3 MAPK3 PDGFRB PDGFRB FGF17 FGF17 LOC114049642 LOC114049642 ENSVURP00010010011 ENSVURP00010010011 FGF23 FGF23 FGF6 FGF6 CD19 CD19 ENSVURP00010009670 ENSVURP00010009670 PPP2CA PPP2CA PIP5K1B PIP5K1B PIP4K2B PIP4K2B PPP2R5D PPP2R5D ERBB2 ERBB2 INSC INSC ENSVURP00010007328 ENSVURP00010007328 FRS2 FRS2 FGF16 FGF16 CD28 CD28 ICOS ICOS FGF22 FGF22 PIK3AP1 PIK3AP1 FGF10 FGF10 INSR INSR FGF18 FGF18 FGFR4 FGFR4 STRN3 STRN3 IER3 IER3 ESR1 ESR1 FGF8 FGF8 PPP2R5B PPP2R5B PDGFB PDGFB ERBB4 ERBB4 PTPN11 PTPN11 LOC114046224 LOC114046224 IRAK4 IRAK4 PPP2R5C PPP2R5C FGF7 FGF7 FGF20 FGF20 AKT1 AKT1 ENSVURP00010032428 ENSVURP00010032428 ENSVURP00010032420 ENSVURP00010032420 ENSVURP00010032211 ENSVURP00010032211 FGF19 FGF19 FGF4 FGF4 FGF3 FGF3 VAV1 VAV1 PIK3CD PIK3CD ERBB3 ERBB3 LOC114038227 LOC114038227 ENSVURP00010030660 ENSVURP00010030660 FNDC3A FNDC3A PIP4K2A PIP4K2A PIP4K2C PIP4K2C ENSVURP00010029292 ENSVURP00010029292 ENSVURP00010029072 ENSVURP00010029072 RHOG RHOG MAPK1 MAPK1 IRAK1 IRAK1 FGF9 FGF9 FGFR3 FGFR3 BANK1 BANK1 FLT3 FLT3 PPP4R4 PPP4R4 RELCH RELCH AKT2 AKT2 ENSVURP00010026284 ENSVURP00010026284 PHLPP2 PHLPP2 MET MET PPP2R1B PPP2R1B PIK3R1 PIK3R1 ENSVURP00010025478 ENSVURP00010025478 ESR2 ESR2 ENSVURP00010024579 ENSVURP00010024579 LOC114034866 LOC114034866 PPP2R5E PPP2R5E FGFR2 FGFR2 LOC114051918 LOC114051918 LOC114024909 LOC114024909 STRN STRN GAB2 GAB2 PIP5KL1 PIP5KL1 FAM102A FAM102A FAM102B FAM102B LOC114049642-2 LOC114049642-2 KITLG KITLG ENSVURP00010020284 ENSVURP00010020284 PHLPP1 PHLPP1 PIK3R2 PIK3R2 FGF2 FGF2 ENSVURP00010019170 ENSVURP00010019170 LOC114043178 LOC114043178 TRAT1 TRAT1 EGFR EGFR HGF HGF ENSVURP00010017524 ENSVURP00010017524 LOC114031856 LOC114031856 LRRC40 LRRC40 NRG4 NRG4 FNDC3B FNDC3B PIK3CA PIK3CA LOC114023983 LOC114023983 NRG1 NRG1 PPP2CB PPP2CB TGFA TGFA INS INS GRB2 GRB2 MYD88 MYD88 TRAF6 TRAF6 PPP2R5A PPP2R5A FGF5 FGF5 KIT KIT PDGFRA PDGFRA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EGFUncharacterized protein. (1191 aa)
ENSVURP00010013703Uncharacterized protein. (1090 aa)
ENSVURP00010013335WD_REPEATS_REGION domain-containing protein. (744 aa)
GAB1PH domain-containing protein. (724 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
AREGEGF-like domain-containing protein. (239 aa)
EREGEpiregulin. (165 aa)
EPGNEGF-like domain-containing protein. (147 aa)
FNBP4Uncharacterized protein. (1047 aa)
HBEGFEGF-like domain-containing protein. (208 aa)
NRG2Neuregulin 2. (794 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PPP2R1AUncharacterized protein. (589 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PDGFRBUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1101 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSVURP00010010011annotation not available (542 aa)
FGF23Uncharacterized protein; Belongs to the heparin-binding growth factors family. (245 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
CD19Uncharacterized protein. (586 aa)
ENSVURP00010009670Uncharacterized protein. (1068 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PIP5K1BPIPK domain-containing protein. (539 aa)
PIP4K2BPIPK domain-containing protein. (416 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
INSCINSC spindle orientation adaptor protein. (485 aa)
ENSVURP00010007328Uncharacterized protein. (312 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
CD28IGv domain-containing protein. (221 aa)
ICOSIGv domain-containing protein. (203 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (186 aa)
PIK3AP1DBB domain-containing protein. (810 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
INSRTyrosine-protein kinase receptor. (1374 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGFR4Fibroblast growth factor receptor. (849 aa)
STRN3WD_REPEATS_REGION domain-containing protein. (803 aa)
IER3Uncharacterized protein. (153 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (494 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LOC114046224Uncharacterized protein. (542 aa)
IRAK4Protein kinase domain-containing protein. (460 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (565 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSVURP00010032428PIPK domain-containing protein. (604 aa)
ENSVURP00010032420Uncharacterized protein. (90 aa)
ENSVURP00010032211Serine/threonine-protein phosphatase. (309 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
VAV1Uncharacterized protein. (846 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
ERBB3Protein kinase domain-containing protein. (1338 aa)
LOC114038227Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (643 aa)
ENSVURP00010030660Uncharacterized protein. (470 aa)
FNDC3AUncharacterized protein. (1204 aa)
PIP4K2APIPK domain-containing protein. (406 aa)
PIP4K2CPIPK domain-containing protein. (421 aa)
ENSVURP00010029292annotation not available (956 aa)
ENSVURP00010029072WD_REPEATS_REGION domain-containing protein. (625 aa)
RHOGUncharacterized protein. (191 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
IRAK1Protein kinase domain-containing protein. (727 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGFR3Fibroblast growth factor receptor. (851 aa)
BANK1Uncharacterized protein. (759 aa)
FLT3Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (999 aa)
PPP4R4Uncharacterized protein. (871 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1212 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSVURP00010026284Uncharacterized protein. (330 aa)
PHLPP2PH domain and leucine rich repeat protein phosphatase 2. (1359 aa)
METUncharacterized protein. (1379 aa)
PPP2R1BUncharacterized protein. (662 aa)
PIK3R1Uncharacterized protein. (725 aa)
ENSVURP00010025478annotation not available (211 aa)
ESR2Uncharacterized protein. (532 aa)
ENSVURP00010024579annotation not available (577 aa)
LOC114034866WRNPLPNID domain-containing protein. (943 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
LOC114051918PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
LOC114024909Uncharacterized protein. (464 aa)
STRNWD_REPEATS_REGION domain-containing protein. (814 aa)
GAB2PH domain-containing protein. (682 aa)
PIP5KL1PIPK domain-containing protein. (447 aa)
FAM102AC2 NT-type domain-containing protein. (385 aa)
FAM102BC2 NT-type domain-containing protein. (366 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
ENSVURP00010020284annotation not available (1068 aa)
PHLPP1PH domain and leucine rich repeat protein phosphatase 1. (1643 aa)
PIK3R2Uncharacterized protein. (738 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
ENSVURP00010019170Uncharacterized protein. (344 aa)
LOC114043178PIPK domain-containing protein. (577 aa)
TRAT1Uncharacterized protein. (190 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ENSVURP00010017524Uncharacterized protein. (247 aa)
LOC114031856WRNPLPNID domain-containing protein. (956 aa)
LRRC40Uncharacterized protein. (606 aa)
NRG4EGF-like domain-containing protein. (175 aa)
FNDC3BUncharacterized protein. (1211 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC114023983Uncharacterized protein. (191 aa)
NRG1Uncharacterized protein. (640 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
TGFAEGF-like domain-containing protein. (159 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
GRB2Uncharacterized protein. (217 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (318 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (496 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (273 aa)
KITUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (997 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1086 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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