STRINGSTRING
PDGFRB PDGFRB IRAK4 IRAK4 LOC114046224 LOC114046224 PTPN11 PTPN11 ERBB4 ERBB4 PDGFB PDGFB PPP2R5B PPP2R5B FGF8 FGF8 ESR1 ESR1 IER3 IER3 STRN3 STRN3 FGFR4 FGFR4 FGF18 FGF18 INSR INSR FGF10 FGF10 PIK3AP1 PIK3AP1 FGF22 FGF22 FGF20 FGF20 FGF7 FGF7 ICOS ICOS PPP2R5C PPP2R5C CD28 CD28 FGF16 FGF16 FRS2 FRS2 ENSVURP00010007328 ENSVURP00010007328 INSC INSC ERBB2 ERBB2 PPP2R5D PPP2R5D PIP4K2B PIP4K2B PIP5K1B PIP5K1B KITLG KITLG FAM102B FAM102B FAM102A FAM102A PIP5KL1 PIP5KL1 GAB2 GAB2 STRN STRN LOC114024909 LOC114024909 LOC114051918 LOC114051918 FGFR2 FGFR2 PPP2R5E PPP2R5E LOC114034866 LOC114034866 ENSVURP00010024579 ENSVURP00010024579 ESR2 ESR2 ENSVURP00010025478 ENSVURP00010025478 PIK3R1 PIK3R1 PPP2R1B PPP2R1B MET MET ENSVURP00010026284 ENSVURP00010026284 RELCH RELCH PPP4R4 PPP4R4 FLT3 FLT3 BANK1 BANK1 FGFR3 FGFR3 FGF9 FGF9 IRAK1 IRAK1 MAPK1 MAPK1 RHOG RHOG ENSVURP00010029072 ENSVURP00010029072 ENSVURP00010029292 ENSVURP00010029292 PIP4K2C PIP4K2C PIP4K2A PIP4K2A FNDC3A FNDC3A ENSVURP00010030660 ENSVURP00010030660 LOC114038227 LOC114038227 ERBB3 ERBB3 PIK3CD PIK3CD VAV1 VAV1 FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 ENSVURP00010032211 ENSVURP00010032211 ENSVURP00010032420 ENSVURP00010032420 ENSVURP00010032428 ENSVURP00010032428 EGF EGF PPP2CA PPP2CA ENSVURP00010009670 ENSVURP00010009670 CD19 CD19 FGF6 FGF6 FGF23 FGF23 ENSVURP00010010011 ENSVURP00010010011 FGF17 FGF17 MAPK3 MAPK3 PIK3CB PIK3CB PPP2R1A PPP2R1A FGF1 FGF1 NRG2 NRG2 HBEGF HBEGF FNBP4 FNBP4 EPGN EPGN EREG EREG AREG AREG FGFR1 FGFR1 GAB1 GAB1 ENSVURP00010013335 ENSVURP00010013335 ENSVURP00010013703 ENSVURP00010013703 PDGFRA PDGFRA KIT KIT FGF5 FGF5 PPP2R5A PPP2R5A TRAF6 TRAF6 MYD88 MYD88 GRB2 GRB2 INS INS TGFA TGFA PPP2CB PPP2CB NRG1 NRG1 LOC114023983 LOC114023983 PIK3CA PIK3CA FNDC3B FNDC3B NRG4 NRG4 LOC114031856 LOC114031856 ENSVURP00010017524 ENSVURP00010017524 HGF HGF EGFR EGFR TRAT1 TRAT1 LOC114043178 LOC114043178 ENSVURP00010019170 ENSVURP00010019170 FGF2 FGF2 PIK3R2 PIK3R2 ENSVURP00010020284 ENSVURP00010020284
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFRBUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1101 aa)
IRAK4Protein kinase domain-containing protein. (460 aa)
LOC114046224Uncharacterized protein. (542 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (494 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
IER3Uncharacterized protein. (153 aa)
STRN3WD_REPEATS_REGION domain-containing protein. (803 aa)
FGFR4Fibroblast growth factor receptor. (849 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
INSRTyrosine-protein kinase receptor. (1374 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
PIK3AP1DBB domain-containing protein. (810 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (186 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
ICOSIGv domain-containing protein. (203 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (565 aa)
CD28IGv domain-containing protein. (221 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
ENSVURP00010007328Uncharacterized protein. (312 aa)
INSCINSC spindle orientation adaptor protein. (485 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
PIP4K2BPIPK domain-containing protein. (416 aa)
PIP5K1BPIPK domain-containing protein. (539 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (273 aa)
FAM102BC2 NT-type domain-containing protein. (366 aa)
FAM102AC2 NT-type domain-containing protein. (385 aa)
PIP5KL1PIPK domain-containing protein. (447 aa)
GAB2PH domain-containing protein. (682 aa)
STRNWD_REPEATS_REGION domain-containing protein. (814 aa)
LOC114024909Uncharacterized protein. (464 aa)
LOC114051918PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
LOC114034866WRNPLPNID domain-containing protein. (943 aa)
ENSVURP00010024579annotation not available (577 aa)
ESR2Uncharacterized protein. (532 aa)
ENSVURP00010025478annotation not available (211 aa)
PIK3R1Uncharacterized protein. (725 aa)
PPP2R1BUncharacterized protein. (662 aa)
METUncharacterized protein. (1379 aa)
ENSVURP00010026284Uncharacterized protein. (330 aa)
RELCHRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1212 aa)
PPP4R4Uncharacterized protein. (871 aa)
FLT3Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (999 aa)
BANK1Uncharacterized protein. (759 aa)
FGFR3Fibroblast growth factor receptor. (851 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
IRAK1Protein kinase domain-containing protein. (727 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
RHOGUncharacterized protein. (191 aa)
ENSVURP00010029072WD_REPEATS_REGION domain-containing protein. (625 aa)
ENSVURP00010029292annotation not available (956 aa)
PIP4K2CPIPK domain-containing protein. (421 aa)
PIP4K2APIPK domain-containing protein. (406 aa)
FNDC3AUncharacterized protein. (1204 aa)
ENSVURP00010030660Uncharacterized protein. (470 aa)
LOC114038227Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (643 aa)
ERBB3Protein kinase domain-containing protein. (1338 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
VAV1Uncharacterized protein. (846 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
ENSVURP00010032211Serine/threonine-protein phosphatase. (309 aa)
ENSVURP00010032420Uncharacterized protein. (90 aa)
ENSVURP00010032428PIPK domain-containing protein. (604 aa)
EGFUncharacterized protein. (1191 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ENSVURP00010009670Uncharacterized protein. (1068 aa)
CD19Uncharacterized protein. (586 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF23Uncharacterized protein; Belongs to the heparin-binding growth factors family. (245 aa)
ENSVURP00010010011annotation not available (542 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
PPP2R1AUncharacterized protein. (589 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
NRG2Neuregulin 2. (794 aa)
HBEGFEGF-like domain-containing protein. (208 aa)
FNBP4Uncharacterized protein. (1047 aa)
EPGNEGF-like domain-containing protein. (147 aa)
EREGEpiregulin. (165 aa)
AREGEGF-like domain-containing protein. (239 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
GAB1PH domain-containing protein. (724 aa)
ENSVURP00010013335WD_REPEATS_REGION domain-containing protein. (744 aa)
ENSVURP00010013703Uncharacterized protein. (1090 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1086 aa)
KITUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (997 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (273 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (496 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (318 aa)
GRB2Uncharacterized protein. (217 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
TGFAEGF-like domain-containing protein. (159 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
NRG1Uncharacterized protein. (640 aa)
LOC114023983Uncharacterized protein. (191 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FNDC3BUncharacterized protein. (1211 aa)
NRG4EGF-like domain-containing protein. (175 aa)
LOC114031856WRNPLPNID domain-containing protein. (956 aa)
ENSVURP00010017524Uncharacterized protein. (247 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
TRAT1Uncharacterized protein. (190 aa)
LOC114043178PIPK domain-containing protein. (577 aa)
ENSVURP00010019170Uncharacterized protein. (344 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
PIK3R2Uncharacterized protein. (738 aa)
ENSVURP00010020284annotation not available (1068 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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