STRINGSTRING
CSDE1 CSDE1 HBEGF HBEGF SOS2 SOS2 JAG2 JAG2 PIK3CB PIK3CB IGF1R IGF1R MAPK3 MAPK3 NOTCH2 NOTCH2 DLL4 DLL4 JUN JUN LOC114049642 LOC114049642 JAG1 JAG1 CDKN1B CDKN1B NOTCH1 NOTCH1 LOC114025930 LOC114025930 ADCY5 ADCY5 NCOR1 NCOR1 ENSVURP00010008520 ENSVURP00010008520 ADCY6 ADCY6 MED1 MED1 SHC4 SHC4 ERBB2 ERBB2 ENSVURP00010007480 ENSVURP00010007480 NOTCH4 NOTCH4 AKT1 AKT1 HRAS HRAS ENSVURP00010006355 ENSVURP00010006355 BAD BAD TP53 TP53 MAPK11 MAPK11 MAPK12 MAPK12 SOS1 SOS1 E2F3 E2F3 ESR1 ESR1 ENSVURP00010001268 ENSVURP00010001268 PTRHD1 PTRHD1 ADCY3 ADCY3 NCOA3 NCOA3 ENSVURP00010000873 ENSVURP00010000873 RPS6KB2 RPS6KB2 MAP2K2 MAP2K2 CCND1 CCND1 PRKACA PRKACA PIK3CD PIK3CD MDM2 MDM2 MTOR MTOR NOTCH3 NOTCH3 IGF1 IGF1 RB1 RB1 DLL3 DLL3 E2F2 E2F2 CDK4 CDK4 ADCY4 ADCY4 MAPK10 MAPK10 ENSVURP00010029009 ENSVURP00010029009 ENSVURP00010028940 ENSVURP00010028940 ENSVURP00010028627 ENSVURP00010028627 ENSVURP00010028624 ENSVURP00010028624 MAPK1 MAPK1 ADCY2 ADCY2 ABCB11 ABCB11 AKT2 AKT2 ADCY7 ADCY7 MMP2 MMP2 MAPK9 MAPK9 DLL1 DLL1 PIK3R1 PIK3R1 ENSVURP00010025333 ENSVURP00010025333 CDKN1A CDKN1A E2F1 E2F1 MAPK13 MAPK13 MAPK14 MAPK14 ENSVURP00010024679 ENSVURP00010024679 ENSVURP00010024670 ENSVURP00010024670 ENSVURP00010024661 ENSVURP00010024661 ESR2 ESR2 PRKACG PRKACG CDKN2C CDKN2C FOS FOS ADCY9 ADCY9 MAP2K1 MAP2K1 ENSVURP00010022607 ENSVURP00010022607 LOC114024909 LOC114024909 MMP9 MMP9 MAPK8 MAPK8 ENSVURP00010020795 ENSVURP00010020795 ENSVURP00010020783 ENSVURP00010020783 ENSVURP00010020687 ENSVURP00010020687 LOC114049642-2 LOC114049642-2 KRAS KRAS ENSVURP00010019784 ENSVURP00010019784 ENSVURP00010019760 ENSVURP00010019760 PIK3R2 PIK3R2 ADCY1 ADCY1 BRAF BRAF ENSVURP00010018147 ENSVURP00010018147 EGFR EGFR ENSVURP00010017722 ENSVURP00010017722 SRC SRC RAF1 RAF1 BAX BAX BCL2 BCL2 LOC114023950 LOC114023950 PIK3CA PIK3CA ADCY8 ADCY8 RPS6KB1 RPS6KB1 GRB2 GRB2 ENSVURP00010015196 ENSVURP00010015196 SP1 SP1 PRKACB PRKACB NRAS NRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSDE1Uncharacterized protein. (847 aa)
HBEGFEGF-like domain-containing protein. (208 aa)
SOS2Uncharacterized protein. (1329 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
IGF1RTyrosine-protein kinase receptor. (1362 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NOTCH2Uncharacterized protein. (2477 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (680 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (321 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
CDKN1BUncharacterized protein. (199 aa)
NOTCH1Uncharacterized protein. (2538 aa)
LOC114025930Uncharacterized protein. (172 aa)
ADCY5Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1256 aa)
NCOR1Nuclear receptor corepressor 1. (2462 aa)
ENSVURP00010008520PID domain-containing protein. (342 aa)
ADCY6Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
SHC4Uncharacterized protein. (345 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
ENSVURP00010007480CARM1 domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (607 aa)
NOTCH4Uncharacterized protein. (1978 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASUncharacterized protein. (189 aa)
ENSVURP00010006355Uncharacterized protein. (66 aa)
BADUncharacterized protein. (180 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
MAPK11Mitogen-activated protein kinase. (362 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
SOS1Uncharacterized protein. (1332 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
ENSVURP00010001268SH2 domain-containing protein. (100 aa)
PTRHD1Uncharacterized protein. (126 aa)
ADCY3Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
NCOA3Nuclear receptor coactivator. (1397 aa)
ENSVURP00010000873Uncharacterized protein. (593 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (474 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
MDM2Uncharacterized protein. (534 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
NOTCH3Uncharacterized protein. (2274 aa)
IGF1Insulin like growth factor 1. (229 aa)
RB1Uncharacterized protein. (927 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (593 aa)
E2F2E2F transcription factor 2. (431 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
ADCY4Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
MAPK10Mitogen-activated protein kinase. (449 aa)
ENSVURP00010029009Uncharacterized protein. (566 aa)
ENSVURP00010028940Protein kinase domain-containing protein. (69 aa)
ENSVURP00010028627annotation not available (228 aa)
ENSVURP00010028624annotation not available (159 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
ADCY2Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
ABCB11Uncharacterized protein. (1323 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ADCY7Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1081 aa)
MMP2Uncharacterized protein. (664 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (733 aa)
PIK3R1Uncharacterized protein. (725 aa)
ENSVURP00010025333annotation not available (375 aa)
CDKN1AUncharacterized protein. (164 aa)
E2F1E2F transcription factor 1. (431 aa)
MAPK13Mitogen-activated protein kinase. (356 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSVURP00010024679Focal_AT domain-containing protein. (115 aa)
ENSVURP00010024670Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (455 aa)
ENSVURP00010024661FERM domain-containing protein. (121 aa)
ESR2Uncharacterized protein. (532 aa)
PRKACGUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (167 aa)
FOSBZIP domain-containing protein. (378 aa)
ADCY9Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
ENSVURP00010022607G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (375 aa)
LOC114024909Uncharacterized protein. (464 aa)
MMP9Uncharacterized protein. (702 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSVURP00010020795Uncharacterized protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (228 aa)
ENSVURP00010020783CARM1 domain-containing protein. (159 aa)
ENSVURP00010020687Uncharacterized protein. (578 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KRASUncharacterized protein. (189 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
PIK3R2Uncharacterized protein. (738 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1129 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (741 aa)
ENSVURP00010018147annotation not available (1253 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
ENSVURP00010017722SWIB domain-containing protein. (173 aa)
SRCTyrosine-protein kinase. (532 aa)
RAF1Uncharacterized protein. (667 aa)
BAXUncharacterized protein. (200 aa)
BCL2BCL2 apoptosis regulator. (256 aa)
LOC114023950Uncharacterized protein. (203 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (539 aa)
GRB2Uncharacterized protein. (217 aa)
ENSVURP00010015196PID domain-containing protein. (300 aa)
SP1Sp1 transcription factor. (779 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (422 aa)
NRASUncharacterized protein. (189 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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