(36 nodes) Autophagy - other network (Vombatus ursinus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

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protein homology

Your Input:
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ATG12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (139 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
	ULK3	Protein kinase domain-containing protein. (525 aa)
	PPP2CB	Serine/threonine-protein phosphatase. (309 aa)
	ENSVURP00010015727	Uncharacterized protein. (321 aa)
	ENSVURP00010015740	Uncharacterized protein. (437 aa)
	WIPI1	Uncharacterized protein. (449 aa)
	IGBP1	Uncharacterized protein. (341 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (718 aa)
	ATG3	Autophagy-related protein 3. (313 aa)
	ATG10	Autophagy_act_C domain-containing protein. (206 aa)
	WIPI2	WD repeat domain, phosphoinositide interacting 2. (400 aa)
	ENSVURP00010025661	Uncharacterized protein. (117 aa)
	ATG4B	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (428 aa)
	BECN1	Uncharacterized protein. (448 aa)
	PIK3R4	Uncharacterized protein. (1363 aa)
	PIK3C3	Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
	ATG16L1	WD_REPEATS_REGION domain-containing protein. (607 aa)
	GABARAPL2	Uncharacterized protein. (117 aa)
	MLST8	WD_REPEATS_REGION domain-containing protein. (326 aa)
	RPTOR	WD_REPEATS_REGION domain-containing protein. (1335 aa)
	ATG4C	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (456 aa)
	ATG101	Uncharacterized protein. (253 aa)
	ATG9B	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (815 aa)
	ULK2	Protein kinase domain-containing protein. (1041 aa)
	GABARAPL1	Uncharacterized protein. (140 aa)
	PPP2CA	Serine/threonine-protein phosphatase. (309 aa)
	ATG4A	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (425 aa)
	ATG2A	Autophagy related 2A. (1935 aa)
	GABARAP	Uncharacterized protein. (117 aa)
	ATG2B	Uncharacterized protein. (2074 aa)
	ATG9A	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (839 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
	ENSVURP00010032211	Serine/threonine-protein phosphatase. (309 aa)
	ATG4D	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (563 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG10	ATG101	ENSVURP00010023344	ENSVURP00010010095	Autophagy_act_C domain-containing protein.	Uncharacterized protein.	0.567
ATG10	ATG12	ENSVURP00010023344	ENSVURP00010013524	Autophagy_act_C domain-containing protein.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family.	0.995
ATG10	ATG13	ENSVURP00010023344	ENSVURP00010013601	Autophagy_act_C domain-containing protein.	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily.	0.567
ATG10	ATG16L1	ENSVURP00010023344	ENSVURP00010029281	Autophagy_act_C domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.655
ATG10	ATG2A	ENSVURP00010023344	ENSVURP00010003808	Autophagy_act_C domain-containing protein.	Autophagy related 2A.	0.547
ATG10	ATG2B	ENSVURP00010023344	ENSVURP00010002925	Autophagy_act_C domain-containing protein.	Uncharacterized protein.	0.547
ATG10	ATG3	ENSVURP00010023344	ENSVURP00010018504	Autophagy_act_C domain-containing protein.	Autophagy-related protein 3.	0.644
ATG10	ATG4A	ENSVURP00010023344	ENSVURP00010006472	Autophagy_act_C domain-containing protein.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.592
ATG10	ATG4B	ENSVURP00010023344	ENSVURP00010027703	Autophagy_act_C domain-containing protein.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.597
ATG10	ATG4C	ENSVURP00010023344	ENSVURP00010011813	Autophagy_act_C domain-containing protein.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.573
ATG10	ATG4D	ENSVURP00010023344	ENSVURP00010032725	Autophagy_act_C domain-containing protein.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family.	0.573
ATG10	ATG5	ENSVURP00010023344	ENSVURP00010013025	Autophagy_act_C domain-containing protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.885
ATG10	ATG7	ENSVURP00010023344	ENSVURP00010016984	Autophagy_act_C domain-containing protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.979
ATG10	ATG9A	ENSVURP00010023344	ENSVURP00010000316	Autophagy_act_C domain-containing protein.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.567
ATG10	ATG9B	ENSVURP00010023344	ENSVURP00010009890	Autophagy_act_C domain-containing protein.	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family.	0.549
ATG10	BECN1	ENSVURP00010023344	ENSVURP00010028271	Autophagy_act_C domain-containing protein.	Uncharacterized protein.	0.567
ATG10	ENSVURP00010025661	ENSVURP00010023344	ENSVURP00010025661	Autophagy_act_C domain-containing protein.	Uncharacterized protein.	0.592
ATG10	GABARAP	ENSVURP00010023344	ENSVURP00010003328	Autophagy_act_C domain-containing protein.	Uncharacterized protein.	0.583
ATG10	GABARAPL1	ENSVURP00010023344	ENSVURP00010009694	Autophagy_act_C domain-containing protein.	Uncharacterized protein.	0.583
ATG10	GABARAPL2	ENSVURP00010023344	ENSVURP00010030054	Autophagy_act_C domain-containing protein.	Uncharacterized protein.	0.592