STRINGSTRING
LOC114054147 LOC114054147 ENSVURP00010000485 ENSVURP00010000485 ENSVURP00010000500 ENSVURP00010000500 GAREM2 GAREM2 RAB10 RAB10 ENSVURP00010001019 ENSVURP00010001019 INSR INSR HNF4A HNF4A PRKAA1 PRKAA1 PPP2R2A PPP2R2A ADRA1A ADRA1A PRKAG3 PRKAG3 ADIPOQ ADIPOQ LOC114043698 LOC114043698 ADIPOR1 ADIPOR1 SLC2A4 SLC2A4 PPP2R5B PPP2R5B ULK1 ULK1 LEP LEP PPP2R5C PPP2R5C PPARGC1A PPARGC1A CAMKK2 CAMKK2 CREB1 CREB1 ENSVURP00010006464 ENSVURP00010006464 ENSVURP00010006608 ENSVURP00010006608 AKT1 AKT1 CPT1B CPT1B PFKM PFKM ADIPOR2 ADIPOR2 TBC1D1 TBC1D1 PRKAB1 PRKAB1 PPP2R5D PPP2R5D PRKAG1 PRKAG1 MAP3K7 MAP3K7 IRS1 IRS1 ACACB ACACB PPP2CA PPP2CA PRKAA2 PRKAA2 LOC114049642 LOC114049642 PRKAB2 PRKAB2 LOC114046954 LOC114046954 RHEB RHEB PRKAG2 PRKAG2 G6PC3 G6PC3 PPP2R3A PPP2R3A PPP2R2B PPP2R2B STRADB STRADB IGF1R IGF1R PIK3CB PIK3CB PPP2R1A PPP2R1A FBP1 FBP1 FBP2 FBP2 RPTOR RPTOR SREBF1 SREBF1 STRADA STRADA EIF4EBP1 EIF4EBP1 ENSVURP00010013568 ENSVURP00010013568 SCD5 SCD5 PPP2R2D PPP2R2D TSC2 TSC2 CREB3L1 CREB3L1 PPP2R5A PPP2R5A INS INS ACACA ACACA PPP2CB PPP2CB PFKFB2 PFKFB2 TSC1 TSC1 RPS6KB1 RPS6KB1 ENSVURP00010016188 ENSVURP00010016188 ENSVURP00010016197 ENSVURP00010016197 PIK3CA PIK3CA GYS1 GYS1 PPARG PPARG CD36 CD36 CPT1C CPT1C CREB3L2 CREB3L2 AKT1S1 AKT1S1 LEPR LEPR ENSVURP00010019348 ENSVURP00010019348 PIK3R2 PIK3R2 SIRT1 SIRT1 SCD SCD FASN FASN LOC114049642-2 LOC114049642-2 PPP2R3B PPP2R3B ENSVURP00010021023 ENSVURP00010021023 ENSVURP00010021239 ENSVURP00010021239 HMGCR HMGCR ENSVURP00010021423 ENSVURP00010021423 GYS2 GYS2 CCNA1 CCNA1 ENSVURP00010021673 ENSVURP00010021673 LOC114049993 LOC114049993 STK11 STK11 ENSVURP00010022045 ENSVURP00010022045 PFKL PFKL LOC114024909 LOC114024909 FOXO1 FOXO1 LOC114052309 LOC114052309 PPP2R5E PPP2R5E PFKFB4 PFKFB4 PCK1 PCK1 PFKFB1 PFKFB1 PIK3R1 PIK3R1 LOC114050683 LOC114050683 PPP2R1B PPP2R1B ENSVURP00010026152 ENSVURP00010026152 AKT2 AKT2 CFTR CFTR RAB2B RAB2B PPP2R3C PPP2R3C G6PC2 G6PC2 ENSVURP00010026841 ENSVURP00010026841 G6PC G6PC ENSVURP00010028940 ENSVURP00010028940 PPP2R2C PPP2R2C ENSVURP00010029204 ENSVURP00010029204 ENSVURP00010029373 ENSVURP00010029373 ENSVURP00010029406 ENSVURP00010029406 CAB39 CAB39 ENSVURP00010029463 ENSVURP00010029463 PRKAG1-2 PRKAG1-2 PCK2 PCK2 ENSVURP00010029701 ENSVURP00010029701 LOC114050683-2 LOC114050683-2 CAB39L CAB39L PFKP PFKP IGF1 IGF1 MTOR MTOR PIK3CD PIK3CD ELAVL1 ELAVL1 ENSVURP00010032211 ENSVURP00010032211 CCND1 CCND1 CPT1A CPT1A CREB3L3 CREB3L3 EEF2 EEF2 RPS6KB2 RPS6KB2 RAB11B RAB11B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC114054147Uncharacterized protein. (212 aa)
ENSVURP000100004856PF2K domain-containing protein. (409 aa)
ENSVURP00010000500Uncharacterized protein. (212 aa)
GAREM2CABIT domain-containing protein. (879 aa)
RAB10Uncharacterized protein. (200 aa)
ENSVURP00010001019annotation not available (409 aa)
INSRTyrosine-protein kinase receptor. (1374 aa)
HNF4AUncharacterized protein. (474 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
ADRA1AAdrenoceptor alpha 1A. (439 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (358 aa)
ADIPOQC1q domain-containing protein. (249 aa)
LOC114043698Protein kinase domain-containing protein. (683 aa)
ADIPOR1Uncharacterized protein. (375 aa)
SLC2A4MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
PPP2R5BSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (494 aa)
ULK1Protein kinase domain-containing protein. (1065 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
PPP2R5CSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (565 aa)
PPARGC1APPARG coactivator 1 alpha. (639 aa)
CAMKK2Protein kinase domain-containing protein. (589 aa)
CREB1Uncharacterized protein. (327 aa)
ENSVURP00010006464Uncharacterized protein. (1377 aa)
ENSVURP00010006608Uncharacterized protein. (799 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
CPT1BCarnitine palmitoyltransferase 1B; Belongs to the carnitine/choline acetyltransferase family. (771 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (782 aa)
ADIPOR2Uncharacterized protein. (387 aa)
TBC1D1Uncharacterized protein. (1189 aa)
PRKAB1AMPKBI domain-containing protein. (274 aa)
PPP2R5DSerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (602 aa)
PRKAG1Uncharacterized protein. (330 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (607 aa)
IRS1Uncharacterized protein. (1242 aa)
ACACBUncharacterized protein. (2449 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKAB2AMPKBI domain-containing protein. (274 aa)
LOC114046954Uncharacterized protein. (215 aa)
RHEBUncharacterized protein. (184 aa)
PRKAG2Uncharacterized protein. (580 aa)
G6PC3acidPPc domain-containing protein. (378 aa)
PPP2R3AEF-hand domain-containing protein. (1155 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
STRADBProtein kinase domain-containing protein. (420 aa)
IGF1RTyrosine-protein kinase receptor. (1362 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
PPP2R1AUncharacterized protein. (589 aa)
FBP1FBPase domain-containing protein; Belongs to the FBPase class 1 family. (338 aa)
FBP2FBPase domain-containing protein; Belongs to the FBPase class 1 family. (343 aa)
RPTORWD_REPEATS_REGION domain-containing protein. (1335 aa)
SREBF1BHLH domain-containing protein. (1218 aa)
STRADAProtein kinase domain-containing protein. (431 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (110 aa)
ENSVURP00010013568FOXO-TAD domain-containing protein. (453 aa)
SCD5FA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (333 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
TSC2Rap-GAP domain-containing protein. (1807 aa)
CREB3L1BZIP domain-containing protein. (526 aa)
PPP2R5ASerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (496 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
ACACAUncharacterized protein. (2370 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
PFKFB26PF2K domain-containing protein. (516 aa)
TSC1TSC complex subunit 1. (1146 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (539 aa)
ENSVURP00010016188Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (272 aa)
ENSVURP00010016197Cyclin_N2 domain-containing protein. (148 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (738 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (539 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
CPT1CCarnitine palmitoyltransferase 1C. (799 aa)
CREB3L2BZIP domain-containing protein. (518 aa)
AKT1S1Uncharacterized protein. (257 aa)
LEPRUncharacterized protein. (1162 aa)
ENSVURP00010019348Uncharacterized protein. (196 aa)
PIK3R2Uncharacterized protein. (738 aa)
SIRT1Sirtuin 1. (550 aa)
SCDFA_desaturase domain-containing protein; Belongs to the fatty acid desaturase type 1 family. (362 aa)
FASNCarrier domain-containing protein. (2513 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
PPP2R3BEF-hand domain-containing protein. (580 aa)
ENSVURP00010021023annotation not available (683 aa)
ENSVURP00010021239Uncharacterized protein. (490 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
ENSVURP00010021423Uncharacterized protein; Belongs to the cyclin family. (276 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (701 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (414 aa)
ENSVURP00010021673annotation not available (215 aa)
LOC114049993BZIP domain-containing protein. (389 aa)
STK11Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (441 aa)
ENSVURP00010022045Uncharacterized protein. (677 aa)
PFKLUncharacterized protein. (726 aa)
LOC114024909Uncharacterized protein. (464 aa)
FOXO1Forkhead box O1. (655 aa)
LOC114052309Eukaryotic elongation factor 2 kinase. (725 aa)
PPP2R5ESerine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (467 aa)
PFKFB46PF2K domain-containing protein. (469 aa)
PCK1Uncharacterized protein. (622 aa)
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1. (433 aa)
PIK3R1Uncharacterized protein. (725 aa)
LOC114050683BZIP domain-containing protein. (398 aa)
PPP2R1BUncharacterized protein. (662 aa)
ENSVURP00010026152annotation not available (725 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1478 aa)
RAB2BUncharacterized protein. (216 aa)
PPP2R3CEF-hand_13 domain-containing protein. (449 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
ENSVURP00010026841annotation not available (212 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ENSVURP00010028940Protein kinase domain-containing protein. (69 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
ENSVURP00010029204annotation not available (389 aa)
ENSVURP00010029373Uncharacterized protein. (677 aa)
ENSVURP00010029406IRS-type PTB domain-containing protein. (1133 aa)
CAB39Uncharacterized protein. (341 aa)
ENSVURP00010029463Uncharacterized protein. (330 aa)
PRKAG1-2Uncharacterized protein. (354 aa)
PCK2Uncharacterized protein. (640 aa)
ENSVURP00010029701Uncharacterized protein. (530 aa)
LOC114050683-2Uncharacterized protein. (506 aa)
CAB39LUncharacterized protein. (334 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (811 aa)
IGF1Insulin like growth factor 1. (229 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
ENSVURP00010032211Serine/threonine-protein phosphatase. (309 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
CPT1AUncharacterized protein; Belongs to the carnitine/choline acetyltransferase family. (773 aa)
CREB3L3BZIP domain-containing protein. (468 aa)
EEF2Tr-type G domain-containing protein. (858 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (474 aa)
RAB11BUncharacterized protein. (218 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
Server load: low (20%) [HD]