(105 nodes) Longevity regulating pathway network (Vombatus ursinus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SIRT1	Sirtuin 1. (550 aa)
	KRAS	Uncharacterized protein. (189 aa)
	ENSVURP00010019784	Uncharacterized protein. (218 aa)
	ENSVURP00010019760	Uncharacterized protein. (152 aa)
	PIK3R2	Uncharacterized protein. (738 aa)
	ADCY1	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1129 aa)
	AKT1S1	Uncharacterized protein. (257 aa)
	CREB3L2	BZIP domain-containing protein. (518 aa)
	ENSVURP00010018147	annotation not available (1253 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (539 aa)
	BAX	Uncharacterized protein. (200 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	ADCY8	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1253 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (539 aa)
	TSC1	TSC complex subunit 1. (1146 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
	INS	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
	CREB3L1	BZIP domain-containing protein. (526 aa)
	SESN3	Uncharacterized protein. (485 aa)
	TSC2	Rap-GAP domain-containing protein. (1807 aa)
	SESN1	Uncharacterized protein. (549 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
	ENSVURP00010013568	FOXO-TAD domain-containing protein. (453 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (110 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (422 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	NRAS	Uncharacterized protein. (189 aa)
	CSDE1	Uncharacterized protein. (847 aa)
	RPTOR	WD_REPEATS_REGION domain-containing protein. (1335 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	IGF1R	Tyrosine-protein kinase receptor. (1362 aa)
	EHMT1	Uncharacterized protein. (1309 aa)
	PRKAG2	Uncharacterized protein. (580 aa)
	LOC114037540	Tubulin-specific chaperone A; Belongs to the TBCA family. (76 aa)
	RHEB	Uncharacterized protein. (184 aa)
	PRKAB2	AMPKBI domain-containing protein. (274 aa)
	ADIPOR1	Uncharacterized protein. (375 aa)
	ADIPOQ	C1q domain-containing protein. (249 aa)
	PRKAG3	Protein kinase AMP-activated non-catalytic subunit gamma 3. (358 aa)
	EIF4E1B	Eukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (272 aa)
	EIF4E	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	PRKAA1	Non-specific serine/threonine protein kinase. (559 aa)
	RELA	RHD domain-containing protein. (538 aa)
	LOC114031824	ATG11 domain-containing protein. (1594 aa)
	PTRHD1	Uncharacterized protein. (126 aa)
	ADCY3	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1150 aa)
	INSR	Tyrosine-protein kinase receptor. (1374 aa)
	ATG101	Uncharacterized protein. (253 aa)
	LOC114049642	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	PRKAA2	Non-specific serine/threonine protein kinase. (551 aa)
	IRS1	Uncharacterized protein. (1242 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1256 aa)
	CAMK4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (441 aa)
	PRKAG1	Uncharacterized protein. (330 aa)
	PRKAB1	AMPKBI domain-containing protein. (274 aa)
	ADCY6	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1158 aa)
	ADIPOR2	Uncharacterized protein. (387 aa)
	ENSVURP00010007284	annotation not available (1594 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	ATF6B	Activating transcription factor 6 beta. (731 aa)
	ENSVURP00010006608	Uncharacterized protein. (799 aa)
	ENSVURP00010006464	Uncharacterized protein. (1377 aa)
	HRAS	Uncharacterized protein. (189 aa)
	CREB1	Uncharacterized protein. (327 aa)
	CAMKK2	Protein kinase domain-containing protein. (589 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (639 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
	ULK1	Protein kinase domain-containing protein. (1065 aa)
	APPL1	Uncharacterized protein. (709 aa)
	LOC114036674	Uncharacterized protein. (1213 aa)
	RPS6KB2	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (474 aa)
	CREB3L3	BZIP domain-containing protein. (468 aa)
	PRKACA	Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
	PIK3CD	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
	IGF1	Insulin like growth factor 1. (229 aa)
	LOC114050683-2	Uncharacterized protein. (506 aa)
	ADCY4	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1073 aa)
	EIF4E2	Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
	PRKAG1-2	Uncharacterized protein. (354 aa)
	ENSVURP00010029463	Uncharacterized protein. (330 aa)
	ENSVURP00010029406	IRS-type PTB domain-containing protein. (1133 aa)
	ENSVURP00010029204	annotation not available (389 aa)
	ENSVURP00010028940	Protein kinase domain-containing protein. (69 aa)
	ADCY2	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1100 aa)
	NFKB1	Uncharacterized protein. (1007 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	ADCY7	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1081 aa)
	KL	Klotho. (1052 aa)
	LOC114050683	BZIP domain-containing protein. (398 aa)
	PIK3R1	Uncharacterized protein. (725 aa)
	ATF2	Uncharacterized protein. (577 aa)
	ENSVURP00010025041	Uncharacterized protein. (1250 aa)
	ENSVURP00010024966	Tubulin-specific chaperone A; Belongs to the TBCA family. (77 aa)
	SESN2	Uncharacterized protein. (477 aa)
	ENSVURP00010024795	annotation not available (225 aa)
	PRKACG	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	LOC114031532	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (225 aa)
	ADCY9	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1359 aa)
	ATF4	BZIP domain-containing protein. (349 aa)
	FOXO1	Forkhead box O1. (655 aa)
	LOC114024909	Uncharacterized protein. (464 aa)
	STK11	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (441 aa)
	LOC114049993	BZIP domain-containing protein. (389 aa)
	LOC114049642-2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSVURP00010019168	ENSVURP00010027987	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.698
ADCY1	ADCY4	ENSVURP00010019168	ENSVURP00010029872	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.681
ADCY1	ADCY5	ENSVURP00010019168	ENSVURP00010008583	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.675
ADCY1	ADCY6	ENSVURP00010019168	ENSVURP00010007964	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.674
ADCY1	ADCY7	ENSVURP00010019168	ENSVURP00010026330	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.721
ADCY1	ADCY9	ENSVURP00010019168	ENSVURP00010022965	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.857
ADCY1	AKT1	ENSVURP00010019168	ENSVURP00010006980	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.769
ADCY1	AKT2	ENSVURP00010019168	ENSVURP00010026377	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.901
ADCY1	CAMK4	ENSVURP00010019168	ENSVURP00010008340	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.825
ADCY1	CSDE1	ENSVURP00010019168	ENSVURP00010012517	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.555
ADCY1	HRAS	ENSVURP00010019168	ENSVURP00010006389	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.555
ADCY1	KRAS	ENSVURP00010019168	ENSVURP00010020228	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.555
ADCY1	LOC114049642	ENSVURP00010019168	ENSVURP00010010015	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.769
ADCY1	LOC114049642-2	ENSVURP00010019168	ENSVURP00010020547	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.769
ADCY1	NRAS	ENSVURP00010019168	ENSVURP00010012528	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.555
ADCY1	PRKACA	ENSVURP00010019168	ENSVURP00010031718	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.928
ADCY1	PRKACB	ENSVURP00010019168	ENSVURP00010013312	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.855
ADCY1	PRKACG	ENSVURP00010019168	ENSVURP00010024035	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.928
ADCY1	PTRHD1	ENSVURP00010019168	ENSVURP00010001259	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.791
ADCY2	ADCY1	ENSVURP00010027987	ENSVURP00010019168	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.698