STRINGSTRING
NOTCH3 NOTCH3 CD247 CD247 IL2RB IL2RB IL12B IL12B NFKBIE NFKBIE CD3D CD3D CD3G CD3G CD3E CD3E RBPJ RBPJ LOC114034206 LOC114034206 ENSVURP00010007417 ENSVURP00010007417 IL13 IL13 IL5 IL5 ENSVURP00010007671 ENSVURP00010007671 HLA-DRA HLA-DRA LOC114053528 LOC114053528 LOC114053378 LOC114053378 ENSVURP00010008605 ENSVURP00010008605 JAK2 JAK2 NOTCH1 NOTCH1 TBX21 TBX21 IL4R IL4R JAG1 JAG1 ENSVURP00010009713 ENSVURP00010009713 JUN JUN DLL4 DLL4 NOTCH2 NOTCH2 LOC114025005 LOC114025005 ENSVURP00010010444 ENSVURP00010010444 MAPK3 MAPK3 IL2RA IL2RA JAG2 JAG2 IKBKB IKBKB MAML3 MAML3 MAML2 MAML2 PPP3R1 PPP3R1 IL2RG IL2RG ENSVURP00010016607 ENSVURP00010016607 PPP3CB PPP3CB IL12RB2 IL12RB2 PLCG1 PLCG1 GATA3 GATA3 IL2 IL2 IFNGR1 IFNGR1 JAK3 JAK3 PPP3CC PPP3CC IL12RB1 IL12RB1 ENSVURP00010019467 ENSVURP00010019467 HLA-DMA HLA-DMA PRKCQ PRKCQ LOC114052665 LOC114052665 CHUK CHUK ENSVURP00010020805 ENSVURP00010020805 MAPK8 MAPK8 IL12A IL12A STAT4 STAT4 STAT1 STAT1 ENSVURP00010022993 ENSVURP00010022993 FOS FOS NFATC2 NFATC2 IKBKG IKBKG MAPK14 MAPK14 MAPK13 MAPK13 DLL1 DLL1 MAML1 MAML1 MAPK9 MAPK9 NFATC1 NFATC1 ENSVURP00010026623 ENSVURP00010026623 ENSVURP00010026635 ENSVURP00010026635 NFKBIA NFKBIA ENSVURP00010026737 ENSVURP00010026737 PPP3CA PPP3CA NFKB1 NFKB1 NFATC3 NFATC3 MAPK1 MAPK1 ENSVURP00010028558 ENSVURP00010028558 ENSVURP00010028631 ENSVURP00010028631 MAPK10 MAPK10 ENSVURP00010029419 ENSVURP00010029419 ENSVURP00010029447 ENSVURP00010029447 ENSVURP00010029551 ENSVURP00010029551 ENSVURP00010029556 ENSVURP00010029556 RUNX3 RUNX3 NFKBIB NFKBIB DLL3 DLL3 STAT6 STAT6 MAF MAF RBPJL RBPJL MAPK11 MAPK11 MAPK12 MAPK12 CD4 CD4 RELA RELA ENSVURP00010000041 ENSVURP00010000041 IFNGR2 IFNGR2 IFNG IFNG ZAP70 ZAP70
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH3Uncharacterized protein. (2274 aa)
CD247Uncharacterized protein. (165 aa)
IL2RBFibronectin type-III domain-containing protein. (561 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (332 aa)
NFKBIEANK_REP_REGION domain-containing protein. (360 aa)
CD3DIg_4 domain-containing protein. (191 aa)
CD3GIg_4 domain-containing protein. (186 aa)
CD3EIGc2 domain-containing protein. (204 aa)
RBPJUncharacterized protein. (494 aa)
LOC114034206Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. (665 aa)
ENSVURP00010007417annotation not available (665 aa)
IL13Uncharacterized protein. (145 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (138 aa)
ENSVURP00010007671Ig-like domain-containing protein; Belongs to the MHC class II family. (327 aa)
HLA-DRAIg-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
LOC114053528Ig-like domain-containing protein. (264 aa)
LOC114053378Ig-like domain-containing protein; Belongs to the MHC class II family. (256 aa)
ENSVURP00010008605Ig-like domain-containing protein. (257 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
NOTCH1Uncharacterized protein. (2538 aa)
TBX21T-box_assoc domain-containing protein. (575 aa)
IL4RFibronectin type-III domain-containing protein. (933 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
ENSVURP00010009713Uncharacterized protein. (252 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (321 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (680 aa)
NOTCH2Uncharacterized protein. (2477 aa)
LOC114025005Ig-like domain-containing protein. (266 aa)
ENSVURP00010010444Ig-like domain-containing protein. (244 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IL2RAUncharacterized protein. (300 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1245 aa)
IKBKBProtein kinase domain-containing protein. (757 aa)
MAML3Mastermind like transcriptional coactivator 3. (1135 aa)
MAML2Mastermind like transcriptional coactivator 2. (1138 aa)
PPP3R1Uncharacterized protein. (170 aa)
IL2RGFibronectin type-III domain-containing protein. (358 aa)
ENSVURP00010016607Ig-like domain-containing protein. (136 aa)
PPP3CBSerine/threonine-protein phosphatase. (520 aa)
IL12RB2Uncharacterized protein. (865 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1279 aa)
GATA3Uncharacterized protein. (444 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (141 aa)
IFNGR1Uncharacterized protein. (492 aa)
JAK3Tyrosine-protein kinase. (1110 aa)
PPP3CCSerine/threonine-protein phosphatase. (517 aa)
IL12RB1Uncharacterized protein. (735 aa)
ENSVURP00010019467Uncharacterized protein. (274 aa)
HLA-DMAIg-like domain-containing protein. (265 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (686 aa)
LOC114052665Uncharacterized protein. (284 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (730 aa)
ENSVURP00010020805Ig-like domain-containing protein. (158 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (215 aa)
STAT4Signal transducer and activator of transcription. (749 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
ENSVURP00010022993Ig-like domain-containing protein. (152 aa)
FOSBZIP domain-containing protein. (378 aa)
NFATC2RHD domain-containing protein. (924 aa)
IKBKGCCHC NOA-type domain-containing protein. (575 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (356 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (733 aa)
MAML1Mastermind like transcriptional coactivator 1. (1007 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
NFATC1Nuclear factor of activated T cells 1. (814 aa)
ENSVURP00010026623Ig-like domain-containing protein. (132 aa)
ENSVURP00010026635Ig-like domain-containing protein. (147 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
ENSVURP00010026737DUF1968 domain-containing protein. (185 aa)
PPP3CASerine/threonine-protein phosphatase. (511 aa)
NFKB1Uncharacterized protein. (1007 aa)
NFATC3RHD domain-containing protein. (1087 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
ENSVURP00010028558SH2 domain-containing protein. (618 aa)
ENSVURP00010028631SH2 domain-containing protein. (602 aa)
MAPK10Mitogen-activated protein kinase. (449 aa)
ENSVURP00010029419Tyrosine-protein kinase. (1180 aa)
ENSVURP00010029447Tyrosine-protein kinase. (1149 aa)
ENSVURP00010029551Ig-like domain-containing protein. (203 aa)
ENSVURP00010029556Ig-like domain-containing protein. (161 aa)
RUNX3Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (417 aa)
NFKBIBANK_REP_REGION domain-containing protein. (315 aa)
DLL3Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (593 aa)
STAT6Signal transducer and activator of transcription. (843 aa)
MAFBZIP domain-containing protein; Belongs to the bZIP family. (396 aa)
RBPJLUncharacterized protein. (512 aa)
MAPK11Mitogen-activated protein kinase. (362 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
CD4Uncharacterized protein. (466 aa)
RELARHD domain-containing protein. (538 aa)
ENSVURP00010000041Ig-like domain-containing protein. (139 aa)
IFNGR2Fibronectin type-III domain-containing protein. (357 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
ZAP70Tyrosine-protein kinase. (617 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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