STRINGSTRING
LOC114049642 LOC114049642 SH2B1 SH2B1 NTRK3 NTRK3 IRS1 IRS1 RPS6KA1 RPS6KA1 ENSVURP00010008520 ENSVURP00010008520 CAMK4 CAMK4 SHC4 SHC4 MAPK7 MAPK7 CAMK2D CAMK2D CALM1-2 CALM1-2 FRS2 FRS2 FASLG FASLG AKT1 AKT1 RIPK2 RIPK2 PRDM4 PRDM4 HRAS HRAS ENSVURP00010006355 ENSVURP00010006355 ZFR ZFR BAD BAD NFKBIE NFKBIE IRAK4 IRAK4 PTPN11 PTPN11 MAP3K5 MAP3K5 TP53 TP53 SH2B2 SH2B2 ATF4 ATF4 ENSVURP00010003580 ENSVURP00010003580 CAMK2B CAMK2B LOC114043698 LOC114043698 LOC114043905 LOC114043905 MAPK11 MAPK11 MAPK12 MAPK12 SOS1 SOS1 RELA RELA ENSVURP00010001268 ENSVURP00010001268 BDNF BDNF ENSVURP00010000873 ENSVURP00010000873 RAP1B RAP1B IRAK3 IRAK3 ENSVURP00010031951 ENSVURP00010031951 MAP2K2 MAP2K2 ZFR2 ZFR2 MATK MATK MAP2K7 MAP2K7 ENSVURP00010020687 ENSVURP00010020687 ENSVURP00010020703 ENSVURP00010020703 MAPK8 MAPK8 ENSVURP00010021023 ENSVURP00010021023 ENSVURP00010021031 ENSVURP00010021031 PLCG2 PLCG2 LOC114024909 LOC114024909 MAP2K1 MAP2K1 ARHGDIB ARHGDIB MAP2K5 MAP2K5 NTF3 NTF3 CALML4 CALML4 RHOA RHOA PSEN1 PSEN1 MAPK14 MAPK14 MAPK13 MAPK13 PIK3R1 PIK3R1 LOC114025658-2 LOC114025658-2 MAPK9 MAPK9 AKT2 AKT2 NFKBIA NFKBIA MAP3K1 MAP3K1 NFKB1 NFKB1 IRAK1 IRAK1 ENSVURP00010028310 ENSVURP00010028310 CRKL CRKL MAPK1 MAPK1 ENSVURP00010029009 ENSVURP00010029009 MAPK10 MAPK10 LOC114049642-2 LOC114049642-2 NFKBIB NFKBIB CDC42 CDC42 LOC114038227 LOC114038227 CALML6 CALML6 ENSVURP00010031195 ENSVURP00010031195 ENSVURP00010031201 ENSVURP00010031201 SH2B3 SH2B3 PIK3CD PIK3CD LOC114025658 LOC114025658 KRAS KRAS CALM1-3 CALM1-3 ENSVURP00010019784 ENSVURP00010019784 ENSVURP00010019760 ENSVURP00010019760 GSK3B GSK3B PIK3R2 PIK3R2 PRKCD PRKCD ENSVURP00010019014 ENSVURP00010019014 SORT1 SORT1 BRAF BRAF PLCG1 PLCG1 NTRK1 NTRK1 CAMK2G CAMK2G CALM1 CALM1 RPS6KA5 RPS6KA5 RAF1 RAF1 BAX BAX NTF4 NTF4 BCL2 BCL2 RPS6KA6 RPS6KA6 PIK3CA PIK3CA RAPGEF1 RAPGEF1 GCNA GCNA MAPKAPK2 MAPKAPK2 CSK CSK GRB2 GRB2 RPS6KA3 RPS6KA3 TRAF6 TRAF6 ENSVURP00010015196 ENSVURP00010015196 IRAK2 IRAK2 RPS6KA2 RPS6KA2 ENSVURP00010013568 ENSVURP00010013568 KIDINS220 KIDINS220 GAB1 GAB1 MAP3K3 MAP3K3 NRAS NRAS CSDE1 CSDE1 SOS2 SOS2 PVALEF PVALEF LOC114043289 LOC114043289 CALML3 CALML3 IKBKB IKBKB PIK3CB PIK3CB LOC114049611 LOC114049611 RAP1A RAP1A ARHGDIA ARHGDIA MAPK3 MAPK3 NGF NGF YWHAE YWHAE CAMK2A CAMK2A ENSVURP00010010434 ENSVURP00010010434 ENSVURP00010010429 ENSVURP00010010429 NGFR NGFR JUN JUN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
SH2B1SH2 domain-containing protein. (709 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
IRS1Uncharacterized protein. (1242 aa)
RPS6KA1Ribosomal protein S6 kinase. (753 aa)
ENSVURP00010008520PID domain-containing protein. (342 aa)
CAMK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (441 aa)
SHC4Uncharacterized protein. (345 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (807 aa)
CAMK2DProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (493 aa)
CALM1-2Uncharacterized protein; Belongs to the calmodulin family. (195 aa)
FRS2IRS-type PTB domain-containing protein. (508 aa)
FASLGTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (280 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
RIPK2Uncharacterized protein. (540 aa)
PRDM4Uncharacterized protein. (819 aa)
HRASUncharacterized protein. (189 aa)
ENSVURP00010006355Uncharacterized protein. (66 aa)
ZFRDZF domain-containing protein. (1069 aa)
BADUncharacterized protein. (180 aa)
NFKBIEANK_REP_REGION domain-containing protein. (360 aa)
IRAK4Protein kinase domain-containing protein. (460 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
MAP3K5Protein kinase domain-containing protein. (1387 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
SH2B2Uncharacterized protein. (667 aa)
ATF4BZIP domain-containing protein. (349 aa)
ENSVURP00010003580EF-hand domain-containing protein; Belongs to the calmodulin family. (73 aa)
CAMK2BProtein kinase domain-containing protein. (546 aa)
LOC114043698Protein kinase domain-containing protein. (683 aa)
LOC114043905Uncharacterized protein. (225 aa)
MAPK11Mitogen-activated protein kinase. (362 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
SOS1Uncharacterized protein. (1332 aa)
RELARHD domain-containing protein. (538 aa)
ENSVURP00010001268SH2 domain-containing protein. (100 aa)
BDNFBrain-derived neurotrophic factor; During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. (254 aa)
ENSVURP00010000873Uncharacterized protein. (593 aa)
RAP1BUncharacterized protein. (184 aa)
IRAK3Uncharacterized protein. (605 aa)
ENSVURP00010031951Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (598 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
ZFR2Zinc finger RNA binding protein 2. (992 aa)
MATKTyrosine-protein kinase. (463 aa)
MAP2K7Protein kinase domain-containing protein. (462 aa)
ENSVURP00010020687Uncharacterized protein. (578 aa)
ENSVURP00010020703Uncharacterized protein. (248 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSVURP00010021023annotation not available (683 aa)
ENSVURP00010021031annotation not available (456 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
LOC114024909Uncharacterized protein. (464 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
ARHGDIBUncharacterized protein. (200 aa)
MAP2K5Uncharacterized protein; Belongs to the protein kinase superfamily. (448 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (268 aa)
CALML4Uncharacterized protein. (153 aa)
RHOAUncharacterized protein. (193 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (470 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (356 aa)
PIK3R1Uncharacterized protein. (725 aa)
LOC114025658-2Tyrosine-protein kinase receptor. (824 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
MAP3K1Uncharacterized protein. (1494 aa)
NFKB1Uncharacterized protein. (1007 aa)
IRAK1Protein kinase domain-containing protein. (727 aa)
ENSVURP00010028310annotation not available (195 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
ENSVURP00010029009Uncharacterized protein. (566 aa)
MAPK10Mitogen-activated protein kinase. (449 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
NFKBIBANK_REP_REGION domain-containing protein. (315 aa)
CDC42Uncharacterized protein. (191 aa)
LOC114038227Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (643 aa)
CALML6Calmodulin like 6. (155 aa)
ENSVURP00010031195SAM domain-containing protein. (278 aa)
ENSVURP00010031201Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (187 aa)
SH2B3SH2B adaptor protein 3. (486 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
LOC114025658Tyrosine-protein kinase receptor. (821 aa)
KRASUncharacterized protein. (189 aa)
CALM1-3Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (389 aa)
PIK3R2Uncharacterized protein. (738 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
ENSVURP00010019014Uncharacterized protein; Belongs to the calmodulin family. (136 aa)
SORT1Sortilin. (833 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (741 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1279 aa)
NTRK1Tyrosine-protein kinase receptor. (743 aa)
CAMK2GProtein kinase domain-containing protein. (603 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
RPS6KA5Ribosomal protein S6 kinase. (799 aa)
RAF1Uncharacterized protein. (667 aa)
BAXUncharacterized protein. (200 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (204 aa)
BCL2BCL2 apoptosis regulator. (256 aa)
RPS6KA6Non-specific serine/threonine protein kinase. (714 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RAPGEF1Uncharacterized protein. (1124 aa)
GCNASprT-like domain-containing protein. (362 aa)
MAPKAPK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (422 aa)
CSKTyrosine-protein kinase. (450 aa)
GRB2Uncharacterized protein. (217 aa)
RPS6KA3Ribosomal protein S6 kinase. (740 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
ENSVURP00010015196PID domain-containing protein. (300 aa)
IRAK2Uncharacterized protein. (649 aa)
RPS6KA2Ribosomal protein S6 kinase. (733 aa)
ENSVURP00010013568FOXO-TAD domain-containing protein. (453 aa)
KIDINS220ANK_REP_REGION domain-containing protein. (1752 aa)
GAB1PH domain-containing protein. (724 aa)
MAP3K3Uncharacterized protein. (657 aa)
NRASUncharacterized protein. (189 aa)
CSDE1Uncharacterized protein. (847 aa)
SOS2Uncharacterized protein. (1329 aa)
PVALEFParvalbumin like EF-hand containing. (123 aa)
LOC114043289Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (184 aa)
IKBKBProtein kinase domain-containing protein. (757 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
LOC114049611Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (456 aa)
RAP1AUncharacterized protein. (184 aa)
ARHGDIAUncharacterized protein. (204 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (296 aa)
YWHAE14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (255 aa)
CAMK2ACalcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
ENSVURP00010010434Sulfatase domain-containing protein. (430 aa)
ENSVURP00010010429Sulfatase domain-containing protein. (132 aa)
NGFRNerve growth factor receptor. (428 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (321 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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