STRINGSTRING
PYGM PYGM GEM GEM ENSVURP00010000873 ENSVURP00010000873 PHKA2 PHKA2 INSR INSR ENSVURP00010001268 ENSVURP00010001268 SORBS1 SORBS1 SREBF2 SREBF2 HK3 HK3 FLOT1 FLOT1 PRKAA1 PRKAA1 EIF4E EIF4E EIF4E1B EIF4E1B SOS1 SOS1 PRKAG3 PRKAG3 ENSVURP00010002486 ENSVURP00010002486 LOC114046825 LOC114046825 LOC114043698 LOC114043698 GCK GCK PHKA1 PHKA1 SLC2A4 SLC2A4 ENSVURP00010003580 ENSVURP00010003580 ALKBH4 ALKBH4 ENSVURP00010004342 ENSVURP00010004342 CBL CBL BUD23 BUD23 ENSVURP00010005217 ENSVURP00010005217 PPARGC1A PPARGC1A PPP1R3G PPP1R3G PHKG1 PHKG1 BAD BAD ENSVURP00010006355 ENSVURP00010006355 HRAS HRAS ENSVURP00010006464 ENSVURP00010006464 ENSVURP00010006608 ENSVURP00010006608 AKT1 AKT1 PTPRD PTPRD ENSVURP00010007266 ENSVURP00010007266 CALM1-2 CALM1-2 SHC4 SHC4 PPP1R3B PPP1R3B PRKAB1 PRKAB1 PRKAG1 PRKAG1 ENSVURP00010008520 ENSVURP00010008520 SORBS2 SORBS2 IRS1 IRS1 ACACB ACACB PRKAA2 PRKAA2 LOC114049642 LOC114049642 PRKAB2 PRKAB2 CRYGN CRYGN RHEB RHEB LOC114037540 LOC114037540 PRKAG2 PRKAG2 G6PC3 G6PC3 CRYBB3 CRYBB3 MAPK3 MAPK3 PIK3CB PIK3CB FBP1 FBP1 FBP2 FBP2 PYGL PYGL IKBKB IKBKB CALML3 CALML3 LOC114043289 LOC114043289 SOCS4 SOCS4 PVALEF PVALEF SOS2 SOS2 PPP1R3A PPP1R3A BMT2 BMT2 RPTOR RPTOR CSDE1 CSDE1 NRAS NRAS LOC114052108 LOC114052108 LOC114027938 LOC114027938 TMEM145 TMEM145 SREBF1 SREBF1 FLOT2 FLOT2 MYO9B MYO9B PRKACB PRKACB EIF4EBP1 EIF4EBP1 SOCS3 SOCS3 ENSVURP00010013724 ENSVURP00010013724 PRKAR2B PRKAR2B TSC2 TSC2 INPP5A INPP5A EXOC7 EXOC7 ENSVURP00010015187 ENSVURP00010015187 ENSVURP00010015196 ENSVURP00010015196 HK2 HK2 GRB2 GRB2 INS INS ACACA ACACA TSC1 TSC1 RPS6KB1 RPS6KB1 RAPGEF1 RAPGEF1 PRKAR1A PRKAR1A PIK3CA PIK3CA LOC114023950 LOC114023950 ENSVURP00010017057 ENSVURP00010017057 GYS1 GYS1 PRKCI PRKCI RAF1 RAF1 ENSVURP00010017481 ENSVURP00010017481 CALM1 CALM1 LOC114040414 LOC114040414 PHKB PHKB ENSVURP00010017930 ENSVURP00010017930 ENSVURP00010018459 ENSVURP00010018459 ENSVURP00010018829 ENSVURP00010018829 BRAF BRAF HK1 HK1 HKDC1 HKDC1 ENSVURP00010019014 ENSVURP00010019014 ENSVURP00010019441 ENSVURP00010019441 SORBS3 SORBS3 PIK3R2 PIK3R2 GSK3B GSK3B ENSVURP00010019760 ENSVURP00010019760 ENSVURP00010019784 ENSVURP00010019784 ENSVURP00010019786 ENSVURP00010019786 SOCS2 SOCS2 CALM1-3 CALM1-3 RHOQ RHOQ KRAS KRAS MYO9A MYO9A MKNK2 MKNK2 FASN FASN LOC114049642-2 LOC114049642-2 ENSVURP00010020687 ENSVURP00010020687 MAPK8 MAPK8 ENSVURP00010021023 ENSVURP00010021023 PYGB PYGB GYS2 GYS2 ENSVURP00010022394 ENSVURP00010022394 LOC114024909 LOC114024909 MAP2K1 MAP2K1 FOXO1 FOXO1 ENSVURP00010022739 ENSVURP00010022739 MKNK1 MKNK1 CALML4 CALML4 ENSVURP00010023428 ENSVURP00010023428 PRKACG PRKACG PRKAR2A PRKAR2A PCK1 PCK1 PPP1R3C PPP1R3C PTPN1 PTPN1 ENSVURP00010024791 ENSVURP00010024791 ENSVURP00010024966 ENSVURP00010024966 PTPRF PTPRF PHKG2 PHKG2 ENSVURP00010025454 ENSVURP00010025454 PIK3R1 PIK3R1 MAPK9 MAPK9 AKT2 AKT2 PPP1CB PPP1CB G6PC2 G6PC2 PPP1R3E PPP1R3E ENSVURP00010027441 ENSVURP00010027441 G6PC G6PC ENSVURP00010028310 ENSVURP00010028310 CRKL CRKL MAPK1 MAPK1 ENSVURP00010028940 ENSVURP00010028940 ENSVURP00010029009 ENSVURP00010029009 ENSVURP00010029153 ENSVURP00010029153 MAPK10 MAPK10 INPPL1 INPPL1 ENSVURP00010029406 ENSVURP00010029406 ENSVURP00010029463 ENSVURP00010029463 PRKAG1-2 PRKAG1-2 PCK2 PCK2 ENSVURP00010029701 ENSVURP00010029701 EIF4E2 EIF4E2 CALML6 CALML6 PRKCZ PRKCZ PPP1CC PPP1CC MTOR MTOR PIK3CD PIK3CD ELK3 ELK3 PRKACA PRKACA TRIP10 TRIP10 PTPRS PTPRS MAP2K2 MAP2K2 RPS6KB2 RPS6KB2 PPP1CA PPP1CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PYGMAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (790 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (296 aa)
ENSVURP00010000873Uncharacterized protein. (593 aa)
PHKA2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1226 aa)
INSRTyrosine-protein kinase receptor. (1374 aa)
ENSVURP00010001268SH2 domain-containing protein. (100 aa)
SORBS1Sorbin and SH3 domain containing 1. (918 aa)
SREBF2BHLH domain-containing protein. (1152 aa)
HK3Uncharacterized protein. (913 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (420 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
EIF4EUncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
EIF4E1BEukaryotic translation initiation factor 4E family member 1B; Belongs to the eukaryotic initiation factor 4E family. (272 aa)
SOS1Uncharacterized protein. (1332 aa)
PRKAG3Protein kinase AMP-activated non-catalytic subunit gamma 3. (358 aa)
ENSVURP00010002486Uncharacterized protein. (202 aa)
LOC114046825GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (303 aa)
LOC114043698Protein kinase domain-containing protein. (683 aa)
GCKPhosphotransferase. (450 aa)
PHKA1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1232 aa)
SLC2A4MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ENSVURP00010003580EF-hand domain-containing protein; Belongs to the calmodulin family. (73 aa)
ALKBH4Fe2OG dioxygenase domain-containing protein. (315 aa)
ENSVURP00010004342Uncharacterized protein. (891 aa)
CBLUncharacterized protein. (916 aa)
BUD23Uncharacterized protein. (314 aa)
ENSVURP00010005217Uncharacterized protein. (202 aa)
PPARGC1APPARG coactivator 1 alpha. (639 aa)
PPP1R3GCBM21 domain-containing protein. (387 aa)
PHKG1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (387 aa)
BADUncharacterized protein. (180 aa)
ENSVURP00010006355Uncharacterized protein. (66 aa)
HRASUncharacterized protein. (189 aa)
ENSVURP00010006464Uncharacterized protein. (1377 aa)
ENSVURP00010006608Uncharacterized protein. (799 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PTPRDProtein tyrosine phosphatase receptor type D. (1912 aa)
ENSVURP00010007266Phosphodiesterase. (858 aa)
CALM1-2Uncharacterized protein; Belongs to the calmodulin family. (195 aa)
SHC4Uncharacterized protein. (345 aa)
PPP1R3BProtein phosphatase 1 regulatory subunit. (279 aa)
PRKAB1AMPKBI domain-containing protein. (274 aa)
PRKAG1Uncharacterized protein. (330 aa)
ENSVURP00010008520PID domain-containing protein. (342 aa)
SORBS2Uncharacterized protein. (1204 aa)
IRS1Uncharacterized protein. (1242 aa)
ACACBUncharacterized protein. (2449 aa)
PRKAA2Non-specific serine/threonine protein kinase. (551 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PRKAB2AMPKBI domain-containing protein. (274 aa)
CRYGNCrystallin gamma N; Belongs to the beta/gamma-crystallin family. (176 aa)
RHEBUncharacterized protein. (184 aa)
LOC114037540Tubulin-specific chaperone A; Belongs to the TBCA family. (76 aa)
PRKAG2Uncharacterized protein. (580 aa)
G6PC3acidPPc domain-containing protein. (378 aa)
CRYBB3Uncharacterized protein; Belongs to the beta/gamma-crystallin family. (211 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
FBP1FBPase domain-containing protein; Belongs to the FBPase class 1 family. (338 aa)
FBP2FBPase domain-containing protein; Belongs to the FBPase class 1 family. (343 aa)
PYGLAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (841 aa)
IKBKBProtein kinase domain-containing protein. (757 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (184 aa)
LOC114043289Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
SOCS4Uncharacterized protein. (436 aa)
PVALEFParvalbumin like EF-hand containing. (123 aa)
SOS2Uncharacterized protein. (1329 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1137 aa)
BMT2S-adenosylmethionine sensor upstream of mTORC1; S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 s [...] (405 aa)
RPTORWD_REPEATS_REGION domain-containing protein. (1335 aa)
CSDE1Uncharacterized protein. (847 aa)
NRASUncharacterized protein. (189 aa)
LOC114052108Uncharacterized protein. (382 aa)
LOC114027938GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (305 aa)
TMEM145Transmembrane protein 145. (432 aa)
SREBF1BHLH domain-containing protein. (1218 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
MYO9BUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2176 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (422 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (110 aa)
SOCS3Uncharacterized protein. (226 aa)
ENSVURP00010013724annotation not available (305 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (406 aa)
TSC2Rap-GAP domain-containing protein. (1807 aa)
INPP5AInositol polyphosphate-5-phosphatase A. (413 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (707 aa)
ENSVURP00010015187SH2 domain-containing protein. (98 aa)
ENSVURP00010015196PID domain-containing protein. (300 aa)
HK2Uncharacterized protein. (917 aa)
GRB2Uncharacterized protein. (217 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
ACACAUncharacterized protein. (2370 aa)
TSC1TSC complex subunit 1. (1146 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (539 aa)
RAPGEF1Uncharacterized protein. (1124 aa)
PRKAR1AUncharacterized protein. (380 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC114023950Uncharacterized protein. (203 aa)
ENSVURP00010017057ETS domain-containing protein. (95 aa)
GYS1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (738 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (596 aa)
RAF1Uncharacterized protein. (667 aa)
ENSVURP00010017481FBPase domain-containing protein. (250 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
LOC114040414Pyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
PHKBPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1093 aa)
ENSVURP00010017930Uncharacterized protein. (876 aa)
ENSVURP00010018459GTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (322 aa)
ENSVURP00010018829annotation not available (585 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (741 aa)
HK1Uncharacterized protein. (919 aa)
HKDC1Uncharacterized protein. (917 aa)
ENSVURP00010019014Uncharacterized protein; Belongs to the calmodulin family. (136 aa)
ENSVURP0001001944140S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
SORBS3Uncharacterized protein. (715 aa)
PIK3R2Uncharacterized protein. (738 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (389 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
ENSVURP00010019786Pyruvate kinase; Belongs to the pyruvate kinase family. (573 aa)
SOCS2Suppressor of cytokine signaling 2. (222 aa)
CALM1-3Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
RHOQUncharacterized protein. (220 aa)
KRASUncharacterized protein. (189 aa)
MYO9AUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2597 aa)
MKNK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (470 aa)
FASNCarrier domain-containing protein. (2513 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSVURP00010020687Uncharacterized protein. (578 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSVURP00010021023annotation not available (683 aa)
PYGBAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (843 aa)
GYS2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (701 aa)
ENSVURP00010022394Uncharacterized protein. (72 aa)
LOC114024909Uncharacterized protein. (464 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
FOXO1Forkhead box O1. (655 aa)
ENSVURP00010022739Uncharacterized protein. (439 aa)
MKNK1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
CALML4Uncharacterized protein. (153 aa)
ENSVURP00010023428Uncharacterized protein. (125 aa)
PRKACGUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
PRKAR2AUncharacterized protein. (377 aa)
PCK1Uncharacterized protein. (622 aa)
PPP1R3CProtein phosphatase 1 regulatory subunit 3C; Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. (317 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (423 aa)
ENSVURP00010024791Uncharacterized protein. (93 aa)
ENSVURP00010024966Tubulin-specific chaperone A; Belongs to the TBCA family. (77 aa)
PTPRFUncharacterized protein. (1907 aa)
PHKG2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (403 aa)
ENSVURP00010025454annotation not available (381 aa)
PIK3R1Uncharacterized protein. (725 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
PPP1R3ECBM21 domain-containing protein. (286 aa)
ENSVURP00010027441Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (98 aa)
G6PCGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
ENSVURP00010028310annotation not available (195 aa)
CRKLUncharacterized protein. (303 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
ENSVURP00010028940Protein kinase domain-containing protein. (69 aa)
ENSVURP00010029009Uncharacterized protein. (566 aa)
ENSVURP00010029153Protein kinase domain-containing protein. (542 aa)
MAPK10Mitogen-activated protein kinase. (449 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1015 aa)
ENSVURP00010029406IRS-type PTB domain-containing protein. (1133 aa)
ENSVURP00010029463Uncharacterized protein. (330 aa)
PRKAG1-2Uncharacterized protein. (354 aa)
PCK2Uncharacterized protein. (640 aa)
ENSVURP00010029701Uncharacterized protein. (530 aa)
EIF4E2Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (245 aa)
CALML6Calmodulin like 6. (155 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
ELK3ETS domain-containing protein. (408 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
TRIP10Uncharacterized protein. (542 aa)
PTPRSUncharacterized protein. (1929 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (474 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
Server load: low (16%) [HD]