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PLCG2 PLCG2 ENSVURP00010021023 ENSVURP00010021023 LOC114049642-2 LOC114049642-2 KRAS KRAS ENSVURP00010019971 ENSVURP00010019971 ENSVURP00010019784 ENSVURP00010019784 ENSVURP00010019760 ENSVURP00010019760 GSK3B GSK3B ATP1B4 ATP1B4 RXRB RXRB PIK3R2 PIK3R2 ENSVURP00010019160 ENSVURP00010019160 ENSVURP00010019151 ENSVURP00010019151 PRKCA PRKCA PLCG1 PLCG1 ENSVURP00010017759 ENSVURP00010017759 ENSVURP00010017722 ENSVURP00010017722 SRC SRC RAF1 RAF1 MED12 MED12 PIK3CA PIK3CA MED27 MED27 MED13 MED13 SIN3A SIN3A PFKFB2 PFKFB2 ENSVURP00010015570 ENSVURP00010015570 ENSVURP00010015561 ENSVURP00010015561 LOC114030664 LOC114030664 MYH3 MYH3 LOC114034445 LOC114034445 PRKCG PRKCG MED12L MED12L LOC114034439 LOC114034439 MYH4 MYH4 MYH8 MYH8 ENSVURP00010014291 ENSVURP00010014291 ENSVURP00010014276 ENSVURP00010014276 TSC2 TSC2 SIN3B SIN3B MED17 MED17 PRKACB PRKACB NOTCH1 NOTCH1 SLC9A1 SLC9A1 ENSVURP00010009072 ENSVURP00010009072 RXRA RXRA PLCB4 PLCB4 ATP2A1 ATP2A1 PLCB1 PLCB1 LOC114049642 LOC114049642 GATA4 GATA4 NOTCH2 NOTCH2 RHEB RHEB PLCB2 PLCB2 ATP1A1 ATP1A1 MAPK3 MAPK3 PIK3CB PIK3CB PLCD3 PLCD3 ACTG1 ACTG1 ATP1B3 ATP1B3 HDAC3 HDAC3 ENSVURP00010012149 ENSVURP00010012149 TBC1D4 TBC1D4 ATP1A3 ATP1A3 CSDE1 CSDE1 NRAS NRAS HDAC1 HDAC1 NCOA3 NCOA3 NCOA1 NCOA1 CASP9 CASP9 ESR1 ESR1 MED14 MED14 EP300 EP300 ENSVURP00010002688 ENSVURP00010002688 PLCD4 PLCD4 ATP1A2 ATP1A2 LOC114043698 LOC114043698 ENSVURP00010003212 ENSVURP00010003212 ENSVURP00010003223 ENSVURP00010003223 ENSVURP00010003370 ENSVURP00010003370 ENSVURP00010004022 ENSVURP00010004022 ATP1B2 ATP1B2 TP53 TP53 ENSVURP00010005215 ENSVURP00010005215 ATP1B1 ATP1B1 RCAN2 RCAN2 RCAN1 RCAN1 ATP2A2 ATP2A2 BAD BAD PLCB3 PLCB3 ENSVURP00010006355 ENSVURP00010006355 HRAS HRAS MED13L MED13L SLC16A2 SLC16A2 THRA THRA AKT1 AKT1 MED24 MED24 NOTCH4 NOTCH4 PFKM PFKM MED1 MED1 NCOR1 NCOR1 MED16 MED16 NOTCH3 NOTCH3 MAP2K2 MAP2K2 CCND1 CCND1 ENSVURP00010032159 ENSVURP00010032159 ATP2A3 ATP2A3 PRKACA PRKACA PIK3CD PIK3CD MDM2 MDM2 MTOR MTOR PFKP PFKP WNT4 WNT4 MED4 MED4 RCAN3 RCAN3 PLN PLN HDAC2 HDAC2 MYH7 MYH7 THRB THRB KAT2B KAT2B KAT2A KAT2A MAPK1 MAPK1 CTNNB1 CTNNB1 ENSVURP00010027358 ENSVURP00010027358 AKT2 AKT2 PIK3R1 PIK3R1 SLC2A1 SLC2A1 PRKACG PRKACG ACTB ACTB HIF1A HIF1A ITGAV ITGAV CREBBP CREBBP STAT1 STAT1 FOXO1 FOXO1 MAP2K1 MAP2K1 LOC114024909 LOC114024909 PRKCB PRKCB MED30 MED30 PFKL PFKL SLCO1C1 SLCO1C1 PLCD1 PLCD1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
ENSVURP00010021023annotation not available (683 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KRASUncharacterized protein. (189 aa)
ENSVURP00010019971PAS domain-containing protein. (1382 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (389 aa)
ATP1B4Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (324 aa)
RXRBRetinoid X receptor beta. (472 aa)
PIK3R2Uncharacterized protein. (738 aa)
ENSVURP00010019160Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (124 aa)
ENSVURP00010019151Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (135 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1279 aa)
ENSVURP00010017759annotation not available (448 aa)
ENSVURP00010017722SWIB domain-containing protein. (173 aa)
SRCTyrosine-protein kinase. (532 aa)
RAF1Uncharacterized protein. (667 aa)
MED12Mediator complex subunit 12. (2158 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MED27Mediator complex subunit 27. (172 aa)
MED13Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2175 aa)
SIN3AHDAC_interact domain-containing protein. (1274 aa)
PFKFB26PF2K domain-containing protein. (516 aa)
ENSVURP00010015570MFS domain-containing protein. (201 aa)
ENSVURP00010015561Uncharacterized protein. (304 aa)
LOC114030664Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (448 aa)
MYH3Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
LOC114034445Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa)
MED12LMediator complex subunit 12 like. (1812 aa)
LOC114034439Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1934 aa)
MYH4Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1940 aa)
MYH8Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
ENSVURP00010014291annotation not available (318 aa)
ENSVURP00010014276Uncharacterized protein. (318 aa)
TSC2Rap-GAP domain-containing protein. (1807 aa)
SIN3BHDAC_interact domain-containing protein. (1097 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (649 aa)
PRKACBProtein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (422 aa)
NOTCH1Uncharacterized protein. (2538 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (807 aa)
ENSVURP00010009072Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (120 aa)
RXRAUncharacterized protein. (483 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1005 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GATA4GATA binding protein 4. (450 aa)
NOTCH2Uncharacterized protein. (2477 aa)
RHEBUncharacterized protein. (184 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
ATP1A1Sodium/potassium-transporting ATPase subunit alpha. (1021 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
PLCD3Phosphoinositide phospholipase C. (819 aa)
ACTG1Uncharacterized protein. (375 aa)
ATP1B3Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (278 aa)
HDAC3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (428 aa)
ENSVURP00010012149Integrin beta; Belongs to the integrin beta chain family. (761 aa)
TBC1D4Rab-GAP TBC domain-containing protein. (1084 aa)
ATP1A3Sodium/potassium-transporting ATPase subunit alpha. (1027 aa)
CSDE1Uncharacterized protein. (847 aa)
NRASUncharacterized protein. (189 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
NCOA3Nuclear receptor coactivator. (1397 aa)
NCOA1Nuclear receptor coactivator. (1444 aa)
CASP9Uncharacterized protein; Belongs to the peptidase C14A family. (424 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (589 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1390 aa)
EP300Uncharacterized protein. (2440 aa)
ENSVURP00010002688Cation_ATPase_C domain-containing protein. (165 aa)
PLCD4Phosphoinositide phospholipase C. (727 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
LOC114043698Protein kinase domain-containing protein. (683 aa)
ENSVURP00010003212Uncharacterized protein. (340 aa)
ENSVURP00010003223Nuc_recep-AF1 domain-containing protein. (117 aa)
ENSVURP00010003370Phosphoinositide phospholipase C. (1544 aa)
ENSVURP00010004022Iodothyronine deiodinase; Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine). (132 aa)
ATP1B2Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (290 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
ENSVURP00010005215annotation not available (1544 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (277 aa)
RCAN2Uncharacterized protein. (198 aa)
RCAN1Uncharacterized protein. (197 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1042 aa)
BADUncharacterized protein. (180 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa)
ENSVURP00010006355Uncharacterized protein. (66 aa)
HRASUncharacterized protein. (189 aa)
MED13LMediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (2218 aa)
SLC16A2MFS domain-containing protein. (494 aa)
THRAUncharacterized protein. (408 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
MED24Uncharacterized protein. (1016 aa)
NOTCH4Uncharacterized protein. (1978 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (782 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1582 aa)
NCOR1Nuclear receptor corepressor 1. (2462 aa)
MED16Mediator of RNA polymerase II transcription subunit 16; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (831 aa)
NOTCH3Uncharacterized protein. (2274 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
ENSVURP00010032159FXYD domain-containing ion transport regulator; Belongs to the FXYD family. (98 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (948 aa)
PRKACAUncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
MDM2Uncharacterized protein. (534 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (811 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (271 aa)
RCAN3Uncharacterized protein. (241 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
HDAC2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
MYH7Myosin heavy chain 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1915 aa)
THRBUncharacterized protein. (476 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (824 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (833 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
CTNNB1Catenin beta 1. (744 aa)
ENSVURP00010027358PAS domain-containing protein. (1356 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
PIK3R1Uncharacterized protein. (725 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
PRKACGUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
ACTBUncharacterized protein. (375 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (814 aa)
ITGAVIntegrin_alpha2 domain-containing protein; Belongs to the integrin alpha chain family. (1063 aa)
CREBBPUncharacterized protein. (2453 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
FOXO1Forkhead box O1. (655 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
LOC114024909Uncharacterized protein. (464 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
MED30Uncharacterized protein. (179 aa)
PFKLUncharacterized protein. (726 aa)
SLCO1C1Solute carrier organic anion transporter family member. (605 aa)
PLCD1Phosphoinositide phospholipase C. (784 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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