STRINGSTRING
ENSVURP00010008908 ENSVURP00010008908 JAK2 JAK2 NOX4 NOX4 THBD THBD AKT1 AKT1 AGER AGER LOC114046109 LOC114046109 ENSVURP00010006622 ENSVURP00010006622 COL4A5 COL4A5 FN1 FN1 EDN1 EDN1 TGFB1 TGFB1 ENSVURP00010003370 ENSVURP00010003370 LOC114039876 LOC114039876 COL1A2 COL1A2 CCND1 CCND1 PIK3CD PIK3CD PRKCZ PRKCZ CDC42 CDC42 CDK4 CDK4 LOC114040557 LOC114040557 ENSVURP00010029953 ENSVURP00010029953 ENSVURP00010029726 ENSVURP00010029726 ENSVURP00010029723 ENSVURP00010029723 VEGFD VEGFD TGFBR2 TGFBR2 ENSVURP00010029423 ENSVURP00010029423 ENSVURP00010029412 ENSVURP00010029412 MAPK10 MAPK10 ENSVURP00010028631 ENSVURP00010028631 ENSVURP00010028558 ENSVURP00010028558 STAT3 STAT3 MAPK1 MAPK1 NFKB1 NFKB1 NFATC1 NFATC1 ENSVURP00010026384 ENSVURP00010026384 AKT2 AKT2 MMP2 MMP2 VEGFA VEGFA ENSVURP00010006397 ENSVURP00010006397 HRAS HRAS ENSVURP00010000763 ENSVURP00010000763 PLCB3 PLCB3 ENSVURP00010005215 ENSVURP00010005215 PLCD4 PLCD4 LOC114050566 LOC114050566 TNF TNF MAPK11 MAPK11 MAPK12 MAPK12 ENSVURP00010002081 ENSVURP00010002081 RELA RELA LOC114031174 LOC114031174 SMAD4 SMAD4 F3 F3 VCAM1 VCAM1 XK XK CYBB CYBB SMAD2 SMAD2 LOC114049551 LOC114049551 MAPK9 MAPK9 PIM1 PIM1 PIK3R1 PIK3R1 MAPK13 MAPK13 MAPK14 MAPK14 ENSVURP00010024378 ENSVURP00010024378 COL3A1 COL3A1 STAT1 STAT1 SMAD3 SMAD3 ENSVURP00010022793 ENSVURP00010022793 FOXO1 FOXO1 LOC114024909 LOC114024909 PRKCB PRKCB ENSVURP00010022363 ENSVURP00010022363 PLCD1 PLCD1 ENSVURP00010021762 ENSVURP00010021762 PLCG2 PLCG2 PRKCE PRKCE MAPK8 MAPK8 LOC114049642-2 LOC114049642-2 KRAS KRAS ENSVURP00010019798 ENSVURP00010019798 ENSVURP00010019784 ENSVURP00010019784 ENSVURP00010019760 ENSVURP00010019760 LOC114052665 LOC114052665 PIK3R2 PIK3R2 PRKCD PRKCD PRKCA PRKCA ENSVURP00010018718 ENSVURP00010018718 PLCG1 PLCG1 BAX BAX BCL2 BCL2 PIK3CA PIK3CA LOC114043334 LOC114043334 NOX1 NOX1 AGTR1 AGTR1 TGFB2 TGFB2 NRAS NRAS CSDE1 CSDE1 CXCL8 CXCL8 DIAPH1 DIAPH1 EGR1 EGR1 PLCD3 PLCD3 PIK3CB PIK3CB IL1B IL1B MAPK3 MAPK3 PLCB2 PLCB2 COL1A1 COL1A1 JUN JUN LOC114049642 LOC114049642 PLCB1 PLCB1 NOS3 NOS3 PLCB4 PLCB4 MFF MFF CDKN1B CDKN1B COL4A3 COL4A3 VEGFC VEGFC COL4A4 COL4A4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSVURP00010008908CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (190 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
NOX4FAD-binding FR-type domain-containing protein. (578 aa)
THBDThrombomodulin. (567 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
AGERUncharacterized protein. (412 aa)
LOC114046109Collagen IV NC1 domain-containing protein. (1704 aa)
ENSVURP00010006622Collagen IV NC1 domain-containing protein. (1241 aa)
COL4A5Collagen type IV alpha 5 chain. (1661 aa)
FN1Uncharacterized protein. (2476 aa)
EDN1Uncharacterized protein. (214 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
ENSVURP00010003370Phosphoinositide phospholipase C. (1544 aa)
LOC114039876Uncharacterized protein. (546 aa)
COL1A2Fibrillar collagen NC1 domain-containing protein. (1336 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa)
CDC42Uncharacterized protein. (191 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
LOC114040557Uncharacterized protein; Belongs to the peptidase C14A family. (276 aa)
ENSVURP00010029953Uncharacterized protein; Belongs to the peptidase C14A family. (274 aa)
ENSVURP00010029726annotation not available (264 aa)
ENSVURP00010029723TGF_BETA_2 domain-containing protein. (264 aa)
VEGFDPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (354 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
ENSVURP00010029423annotation not available (1704 aa)
ENSVURP00010029412Collagen IV NC1 domain-containing protein. (1656 aa)
MAPK10Mitogen-activated protein kinase. (449 aa)
ENSVURP00010028631SH2 domain-containing protein. (602 aa)
ENSVURP00010028558SH2 domain-containing protein. (618 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
NFKB1Uncharacterized protein. (1007 aa)
NFATC1Nuclear factor of activated T cells 1. (814 aa)
ENSVURP00010026384annotation not available (215 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
MMP2Uncharacterized protein. (664 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (400 aa)
ENSVURP00010006397PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (192 aa)
HRASUncharacterized protein. (189 aa)
ENSVURP00010000763annotation not available (468 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa)
ENSVURP00010005215annotation not available (1544 aa)
PLCD4Phosphoinositide phospholipase C. (727 aa)
LOC114050566Uncharacterized protein. (215 aa)
TNFTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (232 aa)
MAPK11Mitogen-activated protein kinase. (362 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
ENSVURP00010002081Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
RELARHD domain-containing protein. (538 aa)
LOC114031174SERPIN domain-containing protein; Belongs to the serpin family. (400 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (292 aa)
VCAM1Uncharacterized protein. (739 aa)
XKXK-related protein. (442 aa)
CYBBCytochrome b-245 beta chain. (572 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
LOC114049551SERPIN domain-containing protein; Belongs to the serpin family. (468 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
PIK3R1Uncharacterized protein. (725 aa)
MAPK13Mitogen-activated protein kinase. (356 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
ENSVURP00010024378annotation not available (97 aa)
COL3A1Uncharacterized protein. (1460 aa)
STAT1Signal transducer and activator of transcription. (750 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
ENSVURP00010022793Uncharacterized protein. (97 aa)
FOXO1Forkhead box O1. (655 aa)
LOC114024909Uncharacterized protein. (464 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
ENSVURP00010022363annotation not available (408 aa)
PLCD1Phosphoinositide phospholipase C. (784 aa)
ENSVURP00010021762annotation not available (509 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (658 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KRASUncharacterized protein. (189 aa)
ENSVURP00010019798annotation not available (145 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
LOC114052665Uncharacterized protein. (284 aa)
PIK3R2Uncharacterized protein. (738 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (677 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
ENSVURP00010018718annotation not available (400 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1279 aa)
BAXUncharacterized protein. (200 aa)
BCL2BCL2 apoptosis regulator. (256 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC114043334C-C motif chemokine. (145 aa)
NOX1NADPH oxidase 1. (587 aa)
AGTR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (356 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
NRASUncharacterized protein. (189 aa)
CSDE1Uncharacterized protein. (847 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
DIAPH1Uncharacterized protein. (1262 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (559 aa)
PLCD3Phosphoinositide phospholipase C. (819 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (299 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
COL1A1Uncharacterized protein. (1453 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (321 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1193 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
MFFMiff domain-containing protein. (329 aa)
CDKN1BUncharacterized protein. (199 aa)
COL4A3Collagen IV NC1 domain-containing protein. (1744 aa)
VEGFCPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (418 aa)
COL4A4Collagen type IV alpha 4 chain. (1599 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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