(74 nodes) Amphetamine addiction network (Vombatus ursinus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CREB3L2	BZIP domain-containing protein. (518 aa)
	DRD1	Dopamine receptor D1; Belongs to the G-protein coupled receptor 1 family. (448 aa)
	HDAC1	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (482 aa)
	CAMK2B	Protein kinase domain-containing protein. (546 aa)
	ENSVURP00010003580	EF-hand domain-containing protein; Belongs to the calmodulin family. (73 aa)
	ATF4	BZIP domain-containing protein. (349 aa)
	MAOA	Amine oxidase. (537 aa)
	MAOB	Amine oxidase. (520 aa)
	GRIN3A	Glutamate ionotropic receptor NMDA type subunit 3A. (1108 aa)
	STX1A	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (278 aa)
	GRIA3	Glutamate ionotropic receptor AMPA type subunit 3. (894 aa)
	CREB1	Uncharacterized protein. (327 aa)
	ATF6B	Activating transcription factor 6 beta. (731 aa)
	GRIA1	Uncharacterized protein. (902 aa)
	CALM1-2	Uncharacterized protein; Belongs to the calmodulin family. (195 aa)
	CAMK2D	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (493 aa)
	PPP1R1B	Uncharacterized protein. (212 aa)
	CAMK4	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (441 aa)
	ADCY5	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1256 aa)
	GRIN2B	Uncharacterized protein. (1491 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (321 aa)
	ENSVURP00010010429	Sulfatase domain-containing protein. (132 aa)
	ENSVURP00010010434	Sulfatase domain-containing protein. (430 aa)
	GRIN1	Uncharacterized protein. (959 aa)
	CAMK2A	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily. (489 aa)
	SLC18A1	MFS domain-containing protein. (522 aa)
	CALML3	Calmodulin like 3; Belongs to the calmodulin family. (184 aa)
	LOC114043289	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	PVALEF	Parvalbumin like EF-hand containing. (123 aa)
	GRIN2A	Glutamate ionotropic receptor NMDA type subunit 2A. (1333 aa)
	PRKACB	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. (422 aa)
	CREB3L1	BZIP domain-containing protein. (526 aa)
	GRIN2D	Glutamate ionotropic receptor NMDA type subunit 2D. (1312 aa)
	PRKCG	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa)
	TH	BH4_AAA_HYDROXYL_2 domain-containing protein. (496 aa)
	GRIN2C	Glutamate ionotropic receptor NMDA type subunit 2C. (868 aa)
	GRIA2	Glutamate ionotropic receptor AMPA type subunit 2. (750 aa)
	PPP3R1	Uncharacterized protein. (170 aa)
	CACNA1D	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1962 aa)
	PPP3CB	Serine/threonine-protein phosphatase. (520 aa)
	CALM1	Uncharacterized protein; Belongs to the calmodulin family. (150 aa)
	CAMK2G	Protein kinase domain-containing protein. (603 aa)
	ENSVURP00010018162	Uncharacterized protein. (84 aa)
	SLC18A2	MFS domain-containing protein. (514 aa)
	PPP1CA	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
	CREB3L3	BZIP domain-containing protein. (468 aa)
	PRKACA	Uncharacterized protein; Belongs to the protein kinase superfamily. (352 aa)
	PPP1CC	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
	ENSVURP00010031323	BH4_AAA_HYDROXYL_2 domain-containing protein. (391 aa)
	CACNA1C	Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2052 aa)
	CALML6	Calmodulin like 6. (155 aa)
	LOC114050683-2	Uncharacterized protein. (506 aa)
	HDAC2	Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (488 aa)
	ENSVURP00010029204	annotation not available (389 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (593 aa)
	ENSVURP00010028310	annotation not available (195 aa)
	PPP3CA	Serine/threonine-protein phosphatase. (511 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (341 aa)
	LOC114050683	BZIP domain-containing protein. (398 aa)
	ATF2	Uncharacterized protein. (577 aa)
	ARC	Arc_C domain-containing protein. (400 aa)
	PRKACG	Uncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
	FOS	BZIP domain-containing protein. (378 aa)
	CALML4	Uncharacterized protein. (153 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
	LOC114049993	BZIP domain-containing protein. (389 aa)
	PDYN	Uncharacterized protein. (258 aa)
	SIRT1	Sirtuin 1. (550 aa)
	CALM1-3	Uncharacterized protein; Belongs to the calmodulin family. (149 aa)
	PPP3CC	Serine/threonine-protein phosphatase. (517 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
	ENSVURP00010019014	Uncharacterized protein; Belongs to the calmodulin family. (136 aa)
	DDC	Dopa decarboxylase. (490 aa)
	GRIA4	Glutamate ionotropic receptor AMPA type subunit 4. (810 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	CALM1	ENSVURP00010008583	ENSVURP00010017595	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.656
ADCY5	CALM1-2	ENSVURP00010008583	ENSVURP00010007590	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.656
ADCY5	CALM1-3	ENSVURP00010008583	ENSVURP00010020020	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.656
ADCY5	CALML3	ENSVURP00010008583	ENSVURP00010011878	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 3; Belongs to the calmodulin family.	0.772
ADCY5	CALML4	ENSVURP00010008583	ENSVURP00010023203	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.783
ADCY5	CALML6	ENSVURP00010008583	ENSVURP00010030933	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calmodulin like 6.	0.815
ADCY5	CAMK2A	ENSVURP00010008583	ENSVURP00010010501	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Calcium/calmodulin dependent protein kinase II alpha; Belongs to the protein kinase superfamily.	0.734
ADCY5	CAMK2B	ENSVURP00010008583	ENSVURP00010003221	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.749
ADCY5	CAMK2D	ENSVURP00010008583	ENSVURP00010007714	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.749
ADCY5	CAMK2G	ENSVURP00010008583	ENSVURP00010017738	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein.	0.773
ADCY5	CAMK4	ENSVURP00010008583	ENSVURP00010008340	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.796
ADCY5	ENSVURP00010003580	ENSVURP00010008583	ENSVURP00010003580	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	EF-hand domain-containing protein; Belongs to the calmodulin family.	0.656
ADCY5	ENSVURP00010019014	ENSVURP00010008583	ENSVURP00010019014	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.656
ADCY5	ENSVURP00010028310	ENSVURP00010008583	ENSVURP00010028310	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	annotation not available	0.656
ADCY5	LOC114043289	ENSVURP00010008583	ENSVURP00010011970	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the calmodulin family.	0.656
ADCY5	PRKACA	ENSVURP00010008583	ENSVURP00010031718	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.925
ADCY5	PRKACB	ENSVURP00010008583	ENSVURP00010013312	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.807
ADCY5	PRKACG	ENSVURP00010008583	ENSVURP00010024035	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.925
ADCY5	PRKCA	ENSVURP00010008583	ENSVURP00010019149	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.773
ADCY5	PRKCB	ENSVURP00010008583	ENSVURP00010022409	Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.773