STRINGSTRING
LOC114024909 LOC114024909 SMAD2 SMAD2 GNAQ GNAQ LOC114026056 LOC114026056 LOC114031174 LOC114031174 RELA RELA PPP2R2A PPP2R2A ENSVURP00010002081 ENSVURP00010002081 MAPK12 MAPK12 MAPK11 MAPK11 TNF TNF LOC114050566 LOC114050566 BDKRB2 BDKRB2 TGFB1 TGFB1 IFNGR1 IFNGR1 IFNGR2 IFNGR2 CD247 CD247 IRAK4 IRAK4 IL12B IL12B LOC114047389 LOC114047389 PLCB3 PLCB3 CD3D CD3D CD3G CD3G CD3E CD3E AKT1 AKT1 FASLG FASLG ENSVURP00010007880 ENSVURP00010007880 ENSVURP00010007892 ENSVURP00010007892 TLR6 TLR6 PPP2CA PPP2CA PLCB4 PLCB4 PLCB1 PLCB1 LOC114049642 LOC114049642 JUN JUN PLCB2 PLCB2 PPP2R2B PPP2R2B MAPK3 MAPK3 CASP8 CASP8 CFLAR CFLAR IL1B IL1B PIK3CB PIK3CB PPP2R1A PPP2R1A IKBKB IKBKB CXCL8 CXCL8 ACE ACE TGFB2 TGFB2 PPP2R2D PPP2R2D NOS2 NOS2 ENSVURP00010014988 ENSVURP00010014988 LOC114053094 LOC114053094 TRAF6 TRAF6 MYD88 MYD88 LOC114043334 LOC114043334 PPP2CB PPP2CB IL10 IL10 TLR2 TLR2 IFNB1 IFNB1 PIK3CA PIK3CA CALR CALR ENSVURP00010016519 ENSVURP00010016519 LOC114042860 LOC114042860 ENSVURP00010016607 ENSVURP00010016607 GNAI1 GNAI1 ENSVURP00010017296 ENSVURP00010017296 GNA11 GNA11 GNA15 GNA15 ENSVURP00010018718 ENSVURP00010018718 GNAI3 GNAI3 ADCY1 ADCY1 IL2 IL2 ENSVURP00010019348 ENSVURP00010019348 PIK3R2 PIK3R2 ENSVURP00010019798 ENSVURP00010019798 LOC114047389-2 LOC114047389-2 CHUK CHUK LOC114049642-2 LOC114049642-2 MAP2K4 MAP2K4 ENSVURP00010020848 ENSVURP00010020848 ENSVURP00010020852 ENSVURP00010020852 MAPK8 MAPK8 ENSVURP00010021504 ENSVURP00010021504 LOC114039188 LOC114039188 IL12A IL12A ENSVURP00010021762 ENSVURP00010021762 TLR9 TLR9 LOC114031799 LOC114031799 ENSVURP00010022363 ENSVURP00010022363 PPP2R2C PPP2R2C MAPK10 MAPK10 ENSVURP00010029428 ENSVURP00010029428 TGFBR2 TGFBR2 ENSVURP00010029551 ENSVURP00010029551 ENSVURP00010029556 ENSVURP00010029556 ENSVURP00010029723 ENSVURP00010029723 ENSVURP00010029726 ENSVURP00010029726 C1QB C1QB C1QC C1QC C1QA C1QA PIK3CD PIK3CD IFNG IFNG C3 C3 ENSVURP00010031982 ENSVURP00010031982 FADD FADD ENSVURP00010032211 ENSVURP00010032211 TICAM1 TICAM1 ENSVURP00010032684 ENSVURP00010032684 ENSVURP00010022760 ENSVURP00010022760 AADAC AADAC KNG1 KNG1 ENSVURP00010022993 ENSVURP00010022993 GNAI2 GNAI2 GNAO1 GNAO1 FOS FOS ENSVURP00010023843 ENSVURP00010023843 ENSVURP00010023988 ENSVURP00010023988 TNFRSF1A TNFRSF1A IKBKG IKBKG MAPK14 MAPK14 MAPK13 MAPK13 PIK3R1 PIK3R1 PPP2R1B PPP2R1B MAPK9 MAPK9 AKT2 AKT2 ENSVURP00010026384 ENSVURP00010026384 ENSVURP00010026572 ENSVURP00010026572 ENSVURP00010026581 ENSVURP00010026581 ENSVURP00010026623 ENSVURP00010026623 ENSVURP00010026635 ENSVURP00010026635 NFKBIA NFKBIA ENSVURP00010026737 ENSVURP00010026737 ENSVURP00010026817 ENSVURP00010026817 NFKB1 NFKB1 IRAK1 IRAK1 MAPK1 MAPK1 ENSVURP00010028805 ENSVURP00010028805
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC114024909Uncharacterized protein. (464 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
GNAQG protein subunit alpha q. (343 aa)
LOC114026056Uncharacterized protein. (355 aa)
LOC114031174SERPIN domain-containing protein; Belongs to the serpin family. (400 aa)
RELARHD domain-containing protein. (538 aa)
PPP2R2ASerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (446 aa)
ENSVURP00010002081Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
MAPK11Mitogen-activated protein kinase. (362 aa)
TNFTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (232 aa)
LOC114050566Uncharacterized protein. (215 aa)
BDKRB2Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (372 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
IFNGR1Uncharacterized protein. (492 aa)
IFNGR2Fibronectin type-III domain-containing protein. (357 aa)
CD247Uncharacterized protein. (165 aa)
IRAK4Protein kinase domain-containing protein. (460 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (332 aa)
LOC114047389TIR domain-containing protein; Belongs to the Toll-like receptor family. (832 aa)
PLCB31-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa)
CD3DIg_4 domain-containing protein. (191 aa)
CD3GIg_4 domain-containing protein. (186 aa)
CD3EIGc2 domain-containing protein. (204 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FASLGTNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (280 aa)
ENSVURP00010007880SCY domain-containing protein. (107 aa)
ENSVURP00010007892annotation not available (107 aa)
TLR6TIR domain-containing protein; Belongs to the Toll-like receptor family. (793 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
PLCB41-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1206 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1117 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (321 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1187 aa)
PPP2R2BSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (471 aa)
CFLARUncharacterized protein; Belongs to the peptidase C14A family. (485 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (299 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
PPP2R1AUncharacterized protein. (589 aa)
IKBKBProtein kinase domain-containing protein. (757 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
ACEAngiotensin-converting enzyme; Belongs to the peptidase M2 family. (1216 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (443 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1153 aa)
ENSVURP00010014988Abhydrolase_3 domain-containing protein. (201 aa)
LOC114053094Uncharacterized protein. (403 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (540 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (318 aa)
LOC114043334C-C motif chemokine. (145 aa)
PPP2CBSerine/threonine-protein phosphatase. (309 aa)
IL10Uncharacterized protein. (206 aa)
TLR2TIR domain-containing protein; Belongs to the Toll-like receptor family. (782 aa)
IFNB1Uncharacterized protein. (190 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
CALRCalreticulin. (418 aa)
ENSVURP00010016519C-C motif chemokine. (90 aa)
LOC114042860SCY domain-containing protein. (142 aa)
ENSVURP00010016607Ig-like domain-containing protein. (136 aa)
GNAI1Uncharacterized protein. (359 aa)
ENSVURP00010017296IGv domain-containing protein. (199 aa)
GNA11Uncharacterized protein. (359 aa)
GNA15Uncharacterized protein. (374 aa)
ENSVURP00010018718annotation not available (400 aa)
GNAI3Uncharacterized protein. (354 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1129 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (141 aa)
ENSVURP00010019348Uncharacterized protein. (196 aa)
PIK3R2Uncharacterized protein. (738 aa)
ENSVURP00010019798annotation not available (145 aa)
LOC114047389-2TIR domain-containing protein; Belongs to the Toll-like receptor family. (881 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (730 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
MAP2K4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (402 aa)
ENSVURP00010020848annotation not available (90 aa)
ENSVURP00010020852annotation not available (142 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
ENSVURP00010021504Uncharacterized protein. (67 aa)
LOC114039188C-C motif chemokine. (91 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (215 aa)
ENSVURP00010021762annotation not available (509 aa)
TLR9TIR domain-containing protein. (1041 aa)
LOC114031799Uncharacterized protein. (379 aa)
ENSVURP00010022363annotation not available (408 aa)
PPP2R2CSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (447 aa)
MAPK10Mitogen-activated protein kinase. (449 aa)
ENSVURP00010029428Ig-like domain-containing protein. (195 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
ENSVURP00010029551Ig-like domain-containing protein. (203 aa)
ENSVURP00010029556Ig-like domain-containing protein. (161 aa)
ENSVURP00010029723TGF_BETA_2 domain-containing protein. (264 aa)
ENSVURP00010029726annotation not available (264 aa)
C1QBC1q domain-containing protein. (277 aa)
C1QCC1q domain-containing protein. (294 aa)
C1QAC1q domain-containing protein. (245 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (164 aa)
C3Uncharacterized protein. (1652 aa)
ENSVURP00010031982Uncharacterized protein. (335 aa)
FADDUncharacterized protein. (193 aa)
ENSVURP00010032211Serine/threonine-protein phosphatase. (309 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (702 aa)
ENSVURP00010032684Uncharacterized protein. (1551 aa)
ENSVURP00010022760Uncharacterized protein. (125 aa)
AADACUncharacterized protein. (393 aa)
KNG1Uncharacterized protein. (618 aa)
ENSVURP00010022993Ig-like domain-containing protein. (152 aa)
GNAI2Uncharacterized protein. (355 aa)
GNAO1Uncharacterized protein. (354 aa)
FOSBZIP domain-containing protein. (378 aa)
ENSVURP00010023843Uncharacterized protein. (151 aa)
ENSVURP00010023988Uncharacterized protein. (423 aa)
TNFRSF1AUncharacterized protein. (459 aa)
IKBKGCCHC NOA-type domain-containing protein. (575 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
MAPK13Mitogen-activated protein kinase. (356 aa)
PIK3R1Uncharacterized protein. (725 aa)
PPP2R1BUncharacterized protein. (662 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSVURP00010026384annotation not available (215 aa)
ENSVURP00010026572Ig-like domain-containing protein. (131 aa)
ENSVURP00010026581Ig-like domain-containing protein. (150 aa)
ENSVURP00010026623Ig-like domain-containing protein. (132 aa)
ENSVURP00010026635Ig-like domain-containing protein. (147 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
ENSVURP00010026737DUF1968 domain-containing protein. (185 aa)
ENSVURP00010026817C-C motif chemokine. (120 aa)
NFKB1Uncharacterized protein. (1007 aa)
IRAK1Protein kinase domain-containing protein. (727 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
ENSVURP00010028805annotation not available (379 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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