STRINGSTRING
AKT2 AKT2 CTNNB1 CTNNB1 MAPK1 MAPK1 ENSVURP00010028940 ENSVURP00010028940 MAPK10 MAPK10 TGFBR2 TGFBR2 BBC3 BBC3 ENSVURP00010029723 ENSVURP00010029723 ENSVURP00010029726 ENSVURP00010029726 ENSVURP00010029953 ENSVURP00010029953 LOC114040557 LOC114040557 MTOR MTOR PIK3CD PIK3CD CCND1 CCND1 RPS6KB2 RPS6KB2 MAP2K2 MAP2K2 TCF7L2 TCF7L2 SMAD2 SMAD2 ENSVURP00010000671 ENSVURP00010000671 LOC114050697 LOC114050697 SMAD4 SMAD4 CASP9 CASP9 DCC DCC ENSVURP00010002081 ENSVURP00010002081 LOC114026424 LOC114026424 SOS1 SOS1 LOC114043682 LOC114043682 APPL1 APPL1 TGFB1 TGFB1 TP53 TP53 LEF1 LEF1 RAC2 RAC2 BAD BAD ENSVURP00010006355 ENSVURP00010006355 HRAS HRAS EGF EGF AKT1 AKT1 GADD45G GADD45G ENSVURP00010008908 ENSVURP00010008908 TCF7 TCF7 LOC114049642 LOC114049642 JUN JUN LOC114034312 LOC114034312 LOC114037676 LOC114037676 LOC114031332 LOC114031332 MAPK3 MAPK3 PIK3CB PIK3CB SOS2 SOS2 CSDE1 CSDE1 NRAS NRAS EPGN EPGN EREG EREG AREG AREG ENSVURP00010013115 ENSVURP00010013115 DDB2 DDB2 TGFB2 TGFB2 BIRC5 BIRC5 ENSVURP00010014024 ENSVURP00010014024 RALB RALB LOC114030664 LOC114030664 GRB2 GRB2 TCF7L1 TCF7L1 TGFA TGFA RALGDS RALGDS RPS6KB1 RPS6KB1 PIK3CA PIK3CA AXIN2 AXIN2 RALA RALA LOC114023950 LOC114023950 BCL2 BCL2 BAX BAX RAF1 RAF1 GADD45A GADD45A ENSVURP00010017759 ENSVURP00010017759 EGFR EGFR BRAF BRAF PIK3R2 PIK3R2 GSK3B GSK3B ENSVURP00010019760 ENSVURP00010019760 ENSVURP00010019784 ENSVURP00010019784 MSH6 MSH6 MSH2 MSH2 KRAS KRAS LOC114049642-2 LOC114049642-2 APC APC BCL2L11 BCL2L11 ENSVURP00010020672 ENSVURP00010020672 MAPK8 MAPK8 BAK1 BAK1 ENSVURP00010021078 ENSVURP00010021078 GADD45B GADD45B POLK POLK ENSVURP00010021762 ENSVURP00010021762 APC2 APC2 ENSVURP00010022363 ENSVURP00010022363 LOC114024909 LOC114024909 MAP2K1 MAP2K1 SMAD3 SMAD3 RAC1 RAC1 FOS FOS RHOA RHOA ENSVURP00010023922 ENSVURP00010023922 MLH1 MLH1 CDKN1A CDKN1A PIK3R1 PIK3R1 MAPK9 MAPK9 ENSVURP00010025884 ENSVURP00010025884 ENSVURP00010025906 ENSVURP00010025906
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
CTNNB1Catenin beta 1. (744 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
ENSVURP00010028940Protein kinase domain-containing protein. (69 aa)
MAPK10Mitogen-activated protein kinase. (449 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (565 aa)
BBC3Uncharacterized protein. (232 aa)
ENSVURP00010029723TGF_BETA_2 domain-containing protein. (264 aa)
ENSVURP00010029726annotation not available (264 aa)
ENSVURP00010029953Uncharacterized protein; Belongs to the peptidase C14A family. (274 aa)
LOC114040557Uncharacterized protein; Belongs to the peptidase C14A family. (276 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (474 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
TCF7L2HMG box domain-containing protein. (605 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSVURP00010000671Uncharacterized protein. (588 aa)
LOC114050697Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
CASP9Uncharacterized protein; Belongs to the peptidase C14A family. (424 aa)
DCCUncharacterized protein. (1449 aa)
ENSVURP00010002081Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
LOC114026424Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (104 aa)
SOS1Uncharacterized protein. (1332 aa)
LOC114043682Uncharacterized protein. (875 aa)
APPL1Uncharacterized protein. (709 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (382 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
LEF1HMG box domain-containing protein. (417 aa)
RAC2Uncharacterized protein. (306 aa)
BADUncharacterized protein. (180 aa)
ENSVURP00010006355Uncharacterized protein. (66 aa)
HRASUncharacterized protein. (189 aa)
EGFUncharacterized protein. (1191 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GADD45GRibosomal_L7Ae domain-containing protein. (159 aa)
ENSVURP00010008908CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (190 aa)
TCF7HMG box domain-containing protein. (430 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (321 aa)
LOC114034312Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC114037676Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
LOC114031332Uncharacterized protein. (192 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
SOS2Uncharacterized protein. (1329 aa)
CSDE1Uncharacterized protein. (847 aa)
NRASUncharacterized protein. (189 aa)
EPGNEGF-like domain-containing protein. (147 aa)
EREGEpiregulin. (165 aa)
AREGEGF-like domain-containing protein. (239 aa)
ENSVURP00010013115Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (103 aa)
DDB2Damage specific DNA binding protein 2. (454 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
BIRC5Uncharacterized protein. (142 aa)
ENSVURP00010014024Uncharacterized protein. (142 aa)
RALBUncharacterized protein. (206 aa)
LOC114030664Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (448 aa)
GRB2Uncharacterized protein. (217 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
TGFAEGF-like domain-containing protein. (159 aa)
RALGDSUncharacterized protein. (827 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (539 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
AXIN2Uncharacterized protein. (837 aa)
RALAUncharacterized protein. (206 aa)
LOC114023950Uncharacterized protein. (203 aa)
BCL2BCL2 apoptosis regulator. (256 aa)
BAXUncharacterized protein. (200 aa)
RAF1Uncharacterized protein. (667 aa)
GADD45ARibosomal_L7Ae domain-containing protein. (166 aa)
ENSVURP00010017759annotation not available (448 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (741 aa)
PIK3R2Uncharacterized protein. (738 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (389 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1436 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
KRASUncharacterized protein. (189 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
APCUncharacterized protein. (2862 aa)
BCL2L11BCL2 like 11. (141 aa)
ENSVURP00010020672annotation not available (875 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
BAK1Uncharacterized protein. (204 aa)
ENSVURP00010021078annotation not available (192 aa)
GADD45BRibosomal_L7Ae domain-containing protein. (160 aa)
POLKUmuC domain-containing protein. (865 aa)
ENSVURP00010021762annotation not available (509 aa)
APC2APC regulator of WNT signaling pathway 2. (2353 aa)
ENSVURP00010022363annotation not available (408 aa)
LOC114024909Uncharacterized protein. (464 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
SMAD3Mothers against decapentaplegic homolog. (426 aa)
RAC1Uncharacterized protein. (211 aa)
FOSBZIP domain-containing protein. (378 aa)
RHOAUncharacterized protein. (193 aa)
ENSVURP00010023922DNA_MISMATCH_REPAIR_2 domain-containing protein. (764 aa)
MLH1DNA_mis_repair domain-containing protein. (743 aa)
CDKN1AUncharacterized protein. (164 aa)
PIK3R1Uncharacterized protein. (725 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
ENSVURP00010025884annotation not available (588 aa)
ENSVURP00010025906annotation not available (211 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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