69 items (Vombatus ursinus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PIK3R2	Uncharacterized protein. (738 aa)
	GSK3B	Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (389 aa)
	ENSVURP00010019760	Uncharacterized protein. (152 aa)
	ENSVURP00010019784	Uncharacterized protein. (218 aa)
	KRAS	Uncharacterized protein. (189 aa)
	ENSVURP00010020351	Uncharacterized protein. (199 aa)
	CTNNA3	Uncharacterized protein. (592 aa)
	LOC114049642-2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	APC	Uncharacterized protein. (2862 aa)
	ENSVURP00010020672	annotation not available (875 aa)
	BAK1	Uncharacterized protein. (204 aa)
	ENSVURP00010021023	annotation not available (683 aa)
	GADD45B	Ribosomal_L7Ae domain-containing protein. (160 aa)
	POLK	UmuC domain-containing protein. (865 aa)
	APC2	APC regulator of WNT signaling pathway 2. (2353 aa)
	LOC114024909	Uncharacterized protein. (464 aa)
	MAP2K1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
	MLH1	DNA_mis_repair domain-containing protein. (743 aa)
	CDKN1A	Uncharacterized protein. (164 aa)
	PIK3R1	Uncharacterized protein. (725 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
	CTNNB1	Catenin beta 1. (744 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
	ENSVURP00010029924	Uncharacterized protein. (61 aa)
	PIK3CD	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
	CCND1	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
	MAP2K2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
	TCF7L2	HMG box domain-containing protein. (605 aa)
	CASP9	Uncharacterized protein; Belongs to the peptidase C14A family. (424 aa)
	SOS1	Uncharacterized protein. (1332 aa)
	LOC114043682	Uncharacterized protein. (875 aa)
	LOC114043698	Protein kinase domain-containing protein. (683 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
	LEF1	HMG box domain-containing protein. (417 aa)
	ENSVURP00010005096	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
	ILK	Uncharacterized protein. (452 aa)
	BAD	Uncharacterized protein. (180 aa)
	ENSVURP00010006355	Uncharacterized protein. (66 aa)
	HRAS	Uncharacterized protein. (189 aa)
	EGF	Uncharacterized protein. (1191 aa)
	AKT1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	GADD45G	Ribosomal_L7Ae domain-containing protein. (159 aa)
	TCF7	HMG box domain-containing protein. (430 aa)
	LOC114049642	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	MAPK3	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
	PIK3CB	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
	CTNNA1	Uncharacterized protein. (906 aa)
	SOS2	Uncharacterized protein. (1329 aa)
	CSDE1	Uncharacterized protein. (847 aa)
	NRAS	Uncharacterized protein. (189 aa)
	DDB2	Damage specific DNA binding protein 2. (454 aa)
	ENSVURP00010013568	FOXO-TAD domain-containing protein. (453 aa)
	LOC114030664	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (448 aa)
	GRB2	Uncharacterized protein. (217 aa)
	TCF7L1	Transcription factor 7 like 1. (597 aa)
	CTNNA2	Uncharacterized protein. (569 aa)
	ENSVURP00010015863	Uncharacterized protein. (354 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	AXIN2	Uncharacterized protein. (837 aa)
	LOC114023950	Uncharacterized protein. (203 aa)
	ENSVURP00010017057	ETS domain-containing protein. (95 aa)
	BAX	Uncharacterized protein. (200 aa)
	RAF1	Uncharacterized protein. (667 aa)
	GADD45A	Ribosomal_L7Ae domain-containing protein. (166 aa)
	ENSVURP00010017759	annotation not available (448 aa)
	EGFR	Receptor protein-tyrosine kinase. (1214 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (741 aa)
	ENSVURP00010019227	Uncharacterized protein. (101 aa)

Your Current Organism:

Vombatus ursinus

NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	APC	ENSVURP00010006980	ENSVURP00010020612	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.495
AKT1	APC2	ENSVURP00010006980	ENSVURP00010021872	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	APC regulator of WNT signaling pathway 2.	0.474
AKT1	AXIN2	ENSVURP00010006980	ENSVURP00010016537	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.465
AKT1	BAD	ENSVURP00010006980	ENSVURP00010006227	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.946
AKT1	BAK1	ENSVURP00010006980	ENSVURP00010020955	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.508
AKT1	BAX	ENSVURP00010006980	ENSVURP00010017144	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.535
AKT1	BRAF	ENSVURP00010006980	ENSVURP00010018833	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	B-Raf proto-oncogene, serine/threonine kinase.	0.755
AKT1	CASP9	ENSVURP00010006980	ENSVURP00010001690	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.837
AKT1	CCND1	ENSVURP00010006980	ENSVURP00010032213	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.406
AKT1	CDKN1A	ENSVURP00010006980	ENSVURP00010025319	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.892
AKT1	CSDE1	ENSVURP00010006980	ENSVURP00010012517	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.495
AKT1	CTNNB1	ENSVURP00010006980	ENSVURP00010028432	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Catenin beta 1.	0.809
AKT1	EGFR	ENSVURP00010006980	ENSVURP00010017895	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Receptor protein-tyrosine kinase.	0.501
AKT1	ENSVURP00010005096	ENSVURP00010006980	ENSVURP00010005096	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.908
AKT1	ENSVURP00010006355	ENSVURP00010006980	ENSVURP00010006355	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.560
AKT1	ENSVURP00010013568	ENSVURP00010006980	ENSVURP00010013568	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	FOXO-TAD domain-containing protein.	0.951
AKT1	ENSVURP00010017759	ENSVURP00010006980	ENSVURP00010017759	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	annotation not available	0.421
AKT1	ENSVURP00010019760	ENSVURP00010006980	ENSVURP00010019760	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.459
AKT1	ENSVURP00010019784	ENSVURP00010006980	ENSVURP00010019784	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.459
AKT1	ENSVURP00010020672	ENSVURP00010006980	ENSVURP00010020672	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	annotation not available	0.476