STRINGSTRING
MAP2K1 MAP2K1 LOC114024909 LOC114024909 ENSVURP00010022183 ENSVURP00010022183 LOC114049993 LOC114049993 MMP9 MMP9 NKX2-3 NKX2-3 ENSVURP00010021023 ENSVURP00010021023 LOC114049642-2 LOC114049642-2 CHUK CHUK KRAS KRAS ENSVURP00010019784 ENSVURP00010019784 ENSVURP00010019760 ENSVURP00010019760 GSK3B GSK3B PIK3R2 PIK3R2 BRAF BRAF ENSVURP00010018401 ENSVURP00010018401 INSRR INSRR CREB3L2 CREB3L2 PDGFD PDGFD EGFR EGFR PLAU PLAU ENSVURP00010017722 ENSVURP00010017722 MMP3 MMP3 RAF1 RAF1 BCL2 BCL2 LOC114023950 LOC114023950 PIK3CA PIK3CA PDGFC PDGFC CCNE1 CCNE1 TGFA TGFA INS INS TCF7L1 TCF7L1 GRB2 GRB2 CREB3L1 CREB3L1 PDGFRA PDGFRA FGFR1 FGFR1 ENSVURP00010012954 ENSVURP00010012954 TCF7L2 TCF7L2 ENSVURP00010032356 ENSVURP00010032356 LOC114038853 LOC114038853 MAP2K2 MAP2K2 CREB3L3 CREB3L3 CCND1 CCND1 PIK3CD PIK3CD MDM2 MDM2 MTOR MTOR ZEB1 ZEB1 IGF1 IGF1 ENSVURP00010031279 ENSVURP00010031279 CDK2 CDK2 RB1 RB1 ENSVURP00010030463 ENSVURP00010030463 ENSVURP00010030459 ENSVURP00010030459 E2F2 E2F2 LOC114050683-2 LOC114050683-2 ENSVURP00010029204 ENSVURP00010029204 MAPK1 MAPK1 NRAS NRAS CSDE1 CSDE1 PLAT PLAT SOS2 SOS2 IKBKB IKBKB PIK3CB PIK3CB IGF1R IGF1R MAPK3 MAPK3 PDGFRB PDGFRB LOC114049642 LOC114049642 TCF7 TCF7 CDKN1B CDKN1B ERBB2 ERBB2 HSP90B1 HSP90B1 AKT1 AKT1 EGF EGF ERG ERG HRAS HRAS ENSVURP00010006355 ENSVURP00010006355 ENSVURP00010006239 ENSVURP00010006239 BAD BAD HSP90AB1 HSP90AB1 CREB1 CREB1 ENSVURP00010005496 ENSVURP00010005496 HSP90AA1 HSP90AA1 ENSVURP00010005096 ENSVURP00010005096 LEF1 LEF1 TP53 TP53 PDGFB PDGFB ATF4 ATF4 LOC114043698 LOC114043698 EP300 EP300 SOS1 SOS1 E2F3 E2F3 RELA RELA CASP9 CASP9 ETV5 ETV5 CTNNB1 CTNNB1 NFKB1 NFKB1 TMPRSS2 TMPRSS2 NFKBIA NFKBIA SRD5A2 SRD5A2 AKT2 AKT2 LOC114050683 LOC114050683 PIK3R1 PIK3R1 ENSVURP00010025478 ENSVURP00010025478 CDKN1A CDKN1A E2F1 E2F1 IKBKG IKBKG CCNE2 CCNE2 FGFR2 FGFR2 CREBBP CREBBP LOC114051918 LOC114051918 FOXO1 FOXO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
LOC114024909Uncharacterized protein. (464 aa)
ENSVURP00010022183Uncharacterized protein. (271 aa)
LOC114049993BZIP domain-containing protein. (389 aa)
MMP9Uncharacterized protein. (702 aa)
NKX2-3NK2 homeobox 3. (286 aa)
ENSVURP00010021023annotation not available (683 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (730 aa)
KRASUncharacterized protein. (189 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (389 aa)
PIK3R2Uncharacterized protein. (738 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (741 aa)
ENSVURP00010018401Uncharacterized protein. (335 aa)
INSRRTyrosine-protein kinase receptor. (1255 aa)
CREB3L2BZIP domain-containing protein. (518 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (345 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
PLAUUncharacterized protein. (426 aa)
ENSVURP00010017722SWIB domain-containing protein. (173 aa)
MMP3ZnMc domain-containing protein. (478 aa)
RAF1Uncharacterized protein. (667 aa)
BCL2BCL2 apoptosis regulator. (256 aa)
LOC114023950Uncharacterized protein. (203 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFCUncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (345 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (370 aa)
TGFAEGF-like domain-containing protein. (159 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (102 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
GRB2Uncharacterized protein. (217 aa)
CREB3L1BZIP domain-containing protein. (526 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1086 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
ENSVURP00010012954Uncharacterized protein. (110 aa)
TCF7L2HMG box domain-containing protein. (605 aa)
ENSVURP00010032356Uncharacterized protein; Belongs to the GST superfamily. (239 aa)
LOC114038853Uncharacterized protein; Belongs to the GST superfamily. (267 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
CREB3L3BZIP domain-containing protein. (468 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
MDM2Uncharacterized protein. (534 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
ZEB1Uncharacterized protein. (1116 aa)
IGF1Insulin like growth factor 1. (229 aa)
ENSVURP00010031279Uncharacterized protein. (392 aa)
CDK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (346 aa)
RB1Uncharacterized protein. (927 aa)
ENSVURP00010030463annotation not available (432 aa)
ENSVURP00010030459Uncharacterized protein. (432 aa)
E2F2E2F transcription factor 2. (431 aa)
LOC114050683-2Uncharacterized protein. (506 aa)
ENSVURP00010029204annotation not available (389 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
NRASUncharacterized protein. (189 aa)
CSDE1Uncharacterized protein. (847 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (564 aa)
SOS2Uncharacterized protein. (1329 aa)
IKBKBProtein kinase domain-containing protein. (757 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
IGF1RTyrosine-protein kinase receptor. (1362 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PDGFRBUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1101 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TCF7HMG box domain-containing protein. (430 aa)
CDKN1BUncharacterized protein. (199 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
HSP90B1HATPase_c domain-containing protein. (800 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EGFUncharacterized protein. (1191 aa)
ERGUncharacterized protein. (478 aa)
HRASUncharacterized protein. (189 aa)
ENSVURP00010006355Uncharacterized protein. (66 aa)
ENSVURP00010006239Uncharacterized protein. (382 aa)
BADUncharacterized protein. (180 aa)
HSP90AB1HATPase_c domain-containing protein. (723 aa)
CREB1Uncharacterized protein. (327 aa)
ENSVURP00010005496Uncharacterized protein. (648 aa)
HSP90AA1HATPase_c domain-containing protein. (728 aa)
ENSVURP00010005096Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
LEF1HMG box domain-containing protein. (417 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
ATF4BZIP domain-containing protein. (349 aa)
LOC114043698Protein kinase domain-containing protein. (683 aa)
EP300Uncharacterized protein. (2440 aa)
SOS1Uncharacterized protein. (1332 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
RELARHD domain-containing protein. (538 aa)
CASP9Uncharacterized protein; Belongs to the peptidase C14A family. (424 aa)
ETV5ETS domain-containing protein. (523 aa)
CTNNB1Catenin beta 1. (744 aa)
NFKB1Uncharacterized protein. (1007 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (495 aa)
NFKBIAANK_REP_REGION domain-containing protein. (321 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase (NADP(+)). (250 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
LOC114050683BZIP domain-containing protein. (398 aa)
PIK3R1Uncharacterized protein. (725 aa)
ENSVURP00010025478annotation not available (211 aa)
CDKN1AUncharacterized protein. (164 aa)
E2F1E2F transcription factor 1. (431 aa)
IKBKGCCHC NOA-type domain-containing protein. (575 aa)
CCNE2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (462 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
CREBBPUncharacterized protein. (2453 aa)
LOC114051918PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FOXO1Forkhead box O1. (655 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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