STRINGSTRING
PIK3CA PIK3CA FGF22 FGF22 FGF10 FGF10 FGF18 FGF18 E2F3 E2F3 FGF8 FGF8 PDGFB PDGFB TP53 TP53 ENSVURP00010005096 ENSVURP00010005096 GALK2 GALK2 FGF7 FGF7 BAD BAD ENSVURP00010006355 ENSVURP00010006355 HRAS HRAS FGF20 FGF20 EGF EGF AKT1 AKT1 FGF16 FGF16 GADD45G GADD45G LOC114025930 LOC114025930 FGF6 FGF6 FGF23 FGF23 LOC114049642 LOC114049642 FGF17 FGF17 MITF MITF PDGFRB PDGFRB MAPK3 MAPK3 IGF1R IGF1R PIK3CB PIK3CB FGF1 FGF1 CSDE1 CSDE1 NRAS NRAS FGFR1 FGFR1 DDB2 DDB2 PDGFRA PDGFRA FGF21 FGF21 FGF5 FGF5 PDGFC PDGFC LOC114023950 LOC114023950 BAX BAX RAF1 RAF1 GADD45A GADD45A HGF HGF ENSVURP00010017722 ENSVURP00010017722 EGFR EGFR PDGFD PDGFD BRAF BRAF FGF2 FGF2 PIK3R2 PIK3R2 ENSVURP00010019760 ENSVURP00010019760 ENSVURP00010019784 ENSVURP00010019784 KRAS KRAS LOC114049642-2 LOC114049642-2 BAK1 BAK1 GADD45B GADD45B POLK POLK LOC114024909 LOC114024909 MAP2K1 MAP2K1 LOC114051918 LOC114051918 E2F1 E2F1 CDKN1A CDKN1A ENSVURP00010025478 ENSVURP00010025478 PIK3R1 PIK3R1 MET MET AKT2 AKT2 FGF9 FGF9 MAPK1 MAPK1 CDK6 CDK6 CDK4 CDK4 E2F2 E2F2 RB1 RB1 IGF1 IGF1 MDM2 MDM2 PIK3CD PIK3CD FGF3 FGF3 FGF4 FGF4 FGF19 FGF19 CCND1 CCND1 MAP2K2 MAP2K2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (186 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (239 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
ENSVURP00010005096Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
GALK2Uncharacterized protein. (458 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
BADUncharacterized protein. (180 aa)
ENSVURP00010006355Uncharacterized protein. (66 aa)
HRASUncharacterized protein. (189 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
EGFUncharacterized protein. (1191 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GADD45GRibosomal_L7Ae domain-containing protein. (159 aa)
LOC114025930Uncharacterized protein. (172 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
FGF23Uncharacterized protein; Belongs to the heparin-binding growth factors family. (245 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (217 aa)
MITFBHLH domain-containing protein. (526 aa)
PDGFRBUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1101 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
IGF1RTyrosine-protein kinase receptor. (1362 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
CSDE1Uncharacterized protein. (847 aa)
NRASUncharacterized protein. (189 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
DDB2Damage specific DNA binding protein 2. (454 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1086 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (202 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (273 aa)
PDGFCUncharacterized protein; Belongs to the PDGF/VEGF growth factor family. (345 aa)
LOC114023950Uncharacterized protein. (203 aa)
BAXUncharacterized protein. (200 aa)
RAF1Uncharacterized protein. (667 aa)
GADD45ARibosomal_L7Ae domain-containing protein. (166 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ENSVURP00010017722SWIB domain-containing protein. (173 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
PDGFDPlatelet derived growth factor D; Belongs to the PDGF/VEGF growth factor family. (345 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (741 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (156 aa)
PIK3R2Uncharacterized protein. (738 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
KRASUncharacterized protein. (189 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BAK1Uncharacterized protein. (204 aa)
GADD45BRibosomal_L7Ae domain-containing protein. (160 aa)
POLKUmuC domain-containing protein. (865 aa)
LOC114024909Uncharacterized protein. (464 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
LOC114051918PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (211 aa)
E2F1E2F transcription factor 1. (431 aa)
CDKN1AUncharacterized protein. (164 aa)
ENSVURP00010025478annotation not available (211 aa)
PIK3R1Uncharacterized protein. (725 aa)
METUncharacterized protein. (1379 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (294 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
E2F2E2F transcription factor 2. (431 aa)
RB1Uncharacterized protein. (927 aa)
IGF1Insulin like growth factor 1. (229 aa)
MDM2Uncharacterized protein. (534 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (274 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (205 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (220 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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