STRINGSTRING
LOC114025930 LOC114025930 E2F3 E2F3 TP53 TP53 HRAS HRAS VEGFA VEGFA EGF EGF TYMP TYMP ERBB2 ERBB2 THBS1 THBS1 MAPK3 MAPK3 DAPK1 DAPK1 HBEGF HBEGF CXCL8 CXCL8 CSDE1 CSDE1 NRAS NRAS LOC114030664 LOC114030664 LOC114023950 LOC114023950 RAF1 RAF1 MMP1 MMP1 RPS6KA5 RPS6KA5 SRC SRC ENSVURP00010017722 ENSVURP00010017722 ENSVURP00010017759 ENSVURP00010017759 EGFR EGFR BRAF BRAF ENSVURP00010019760 ENSVURP00010019760 ENSVURP00010019784 ENSVURP00010019784 KRAS KRAS DAPK2 DAPK2 MMP9 MMP9 MAP2K1 MAP2K1 RASSF1 RASSF1 E2F1 E2F1 CDKN1A CDKN1A MMP2 MMP2 FGFR3 FGFR3 MAPK1 MAPK1 CDK4 CDK4 E2F2 E2F2 RB1 RB1 MDM2 MDM2 ENSVURP00010031809 ENSVURP00010031809 CCND1 CCND1 MAP2K2 MAP2K2 DAPK3 DAPK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC114025930Uncharacterized protein. (172 aa)
E2F3E2F_TDP domain-containing protein. (460 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
HRASUncharacterized protein. (189 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (400 aa)
EGFUncharacterized protein. (1191 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (467 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
THBS1Uncharacterized protein. (1172 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
DAPK1Uncharacterized protein. (1428 aa)
HBEGFEGF-like domain-containing protein. (208 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (145 aa)
CSDE1Uncharacterized protein. (847 aa)
NRASUncharacterized protein. (189 aa)
LOC114030664Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (448 aa)
LOC114023950Uncharacterized protein. (203 aa)
RAF1Uncharacterized protein. (667 aa)
MMP1ZnMc domain-containing protein. (469 aa)
RPS6KA5Ribosomal protein S6 kinase. (799 aa)
SRCTyrosine-protein kinase. (532 aa)
ENSVURP00010017722SWIB domain-containing protein. (173 aa)
ENSVURP00010017759annotation not available (448 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (741 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
KRASUncharacterized protein. (189 aa)
DAPK2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (365 aa)
MMP9Uncharacterized protein. (702 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
RASSF1Uncharacterized protein. (367 aa)
E2F1E2F transcription factor 1. (431 aa)
CDKN1AUncharacterized protein. (164 aa)
MMP2Uncharacterized protein. (664 aa)
FGFR3Fibroblast growth factor receptor. (851 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
E2F2E2F transcription factor 2. (431 aa)
RB1Uncharacterized protein. (927 aa)
MDM2Uncharacterized protein. (534 aa)
ENSVURP00010031809Uncharacterized protein. (163 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
DAPK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (454 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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