STRINGSTRING
E2F3 E2F3 JAK3 JAK3 PRKCA PRKCA BRAF BRAF PLCG1 PLCG1 EGFR EGFR GADD45A GADD45A RAF1 RAF1 BAX BAX LOC114023950 LOC114023950 PIK3CA PIK3CA RASSF5 RASSF5 TGFA TGFA GRB2 GRB2 PRKCG PRKCG ENSVURP00010013568 ENSVURP00010013568 DDB2 DDB2 NRAS NRAS CSDE1 CSDE1 SOS2 SOS2 PIK3CB PIK3CB MAPK3 MAPK3 LOC114049642 LOC114049642 LTK LTK RXRA RXRA LOC114025930 LOC114025930 GADD45G GADD45G ERBB2 ERBB2 AKT1 AKT1 EGF EGF HRAS HRAS ENSVURP00010006355 ENSVURP00010006355 BAD BAD ENSVURP00010006204 ENSVURP00010006204 TP53 TP53 ENSVURP00010003223 ENSVURP00010003223 ENSVURP00010003212 ENSVURP00010003212 LOC114043698 LOC114043698 STK4 STK4 SOS1 SOS1 CASP9 CASP9 EML4 EML4 PIK3R2 PIK3R2 RXRB RXRB LOC114052665 LOC114052665 ENSVURP00010019760 ENSVURP00010019760 ENSVURP00010019784 ENSVURP00010019784 KRAS KRAS LOC114049642-2 LOC114049642-2 BAK1 BAK1 ENSVURP00010021023 ENSVURP00010021023 HGF HGF PLCG2 PLCG2 GADD45B GADD45B POLK POLK PRKCB PRKCB LOC114024909 LOC114024909 MAP2K1 MAP2K1 RASSF1 RASSF1 E2F1 E2F1 CDKN1A CDKN1A PIK3R1 PIK3R1 MET MET AKT2 AKT2 ENSVURP00010026526 ENSVURP00010026526 MAPK1 MAPK1 STAT3 STAT3 ENSVURP00010028558 ENSVURP00010028558 ENSVURP00010028631 ENSVURP00010028631 RARB RARB CDK6 CDK6 CDK4 CDK4 E2F2 E2F2 RB1 RB1 PIK3CD PIK3CD CCND1 CCND1 MAP2K2 MAP2K2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
E2F3E2F_TDP domain-containing protein. (460 aa)
JAK3Tyrosine-protein kinase. (1110 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (614 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (741 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1279 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
GADD45ARibosomal_L7Ae domain-containing protein. (166 aa)
RAF1Uncharacterized protein. (667 aa)
BAXUncharacterized protein. (200 aa)
LOC114023950Uncharacterized protein. (203 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
RASSF5Uncharacterized protein. (418 aa)
TGFAEGF-like domain-containing protein. (159 aa)
GRB2Uncharacterized protein. (217 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (703 aa)
ENSVURP00010013568FOXO-TAD domain-containing protein. (453 aa)
DDB2Damage specific DNA binding protein 2. (454 aa)
NRASUncharacterized protein. (189 aa)
CSDE1Uncharacterized protein. (847 aa)
SOS2Uncharacterized protein. (1329 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LTKTyrosine-protein kinase receptor. (887 aa)
RXRAUncharacterized protein. (483 aa)
LOC114025930Uncharacterized protein. (172 aa)
GADD45GRibosomal_L7Ae domain-containing protein. (159 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EGFUncharacterized protein. (1191 aa)
HRASUncharacterized protein. (189 aa)
ENSVURP00010006355Uncharacterized protein. (66 aa)
BADUncharacterized protein. (180 aa)
ENSVURP00010006204HIT domain-containing protein. (137 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
ENSVURP00010003223Nuc_recep-AF1 domain-containing protein. (117 aa)
ENSVURP00010003212Uncharacterized protein. (340 aa)
LOC114043698Protein kinase domain-containing protein. (683 aa)
STK4Uncharacterized protein. (487 aa)
SOS1Uncharacterized protein. (1332 aa)
CASP9Uncharacterized protein; Belongs to the peptidase C14A family. (424 aa)
EML4Uncharacterized protein. (997 aa)
PIK3R2Uncharacterized protein. (738 aa)
RXRBRetinoid X receptor beta. (472 aa)
LOC114052665Uncharacterized protein. (284 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
KRASUncharacterized protein. (189 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
BAK1Uncharacterized protein. (204 aa)
ENSVURP00010021023annotation not available (683 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1264 aa)
GADD45BRibosomal_L7Ae domain-containing protein. (160 aa)
POLKUmuC domain-containing protein. (865 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (613 aa)
LOC114024909Uncharacterized protein. (464 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
RASSF1Uncharacterized protein. (367 aa)
E2F1E2F transcription factor 1. (431 aa)
CDKN1AUncharacterized protein. (164 aa)
PIK3R1Uncharacterized protein. (725 aa)
METUncharacterized protein. (1379 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSVURP00010026526Tyrosine-protein kinase receptor. (552 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
STAT3Signal transducer and activator of transcription. (771 aa)
ENSVURP00010028558SH2 domain-containing protein. (618 aa)
ENSVURP00010028631SH2 domain-containing protein. (602 aa)
RARBUncharacterized protein. (517 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (294 aa)
CDK4Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (338 aa)
E2F2E2F transcription factor 2. (431 aa)
RB1Uncharacterized protein. (927 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
CCND1Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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