STRINGSTRING
AKT2 AKT2 FLT3 FLT3 SLC7A5 SLC7A5 FGFR3 FGFR3 ENSVURP00010028054 ENSVURP00010028054 MAPK1 MAPK1 ENSVURP00010029530 ENSVURP00010029530 ENSVURP00010029927 ENSVURP00010029927 ENSVURP00010030368 ENSVURP00010030368 GLS2 GLS2 PFKP PFKP ENSVURP00010031228 ENSVURP00010031228 ENSVURP00010031265 ENSVURP00010031265 ENSVURP00010031269 ENSVURP00010031269 MTOR MTOR PIK3CD PIK3CD SIRT6 SIRT6 LDHA LDHA MAP2K2 MAP2K2 PARP8 PARP8 HK3 HK3 GCK GCK ENSVURP00010003442 ENSVURP00010003442 TP53 TP53 ENSVURP00010005096 ENSVURP00010005096 LDHC LDHC ENSVURP00010000232 ENSVURP00010000232 ENSVURP00010019760 ENSVURP00010019760 PIK3R2 PIK3R2 PDHB PDHB HKDC1 HKDC1 HK1 HK1 RET RET NTRK1 NTRK1 EGFR EGFR ENSVURP00010017868 ENSVURP00010017868 ENSVURP00010017759 ENSVURP00010017759 RAF1 RAF1 SLC2A2 SLC2A2 TNIK TNIK PIK3CA PIK3CA PDHA1 PDHA1 HK2 HK2 LOC114030664 LOC114030664 SCO1 SCO1 ENSVURP00010014654 ENSVURP00010014654 LOC114045424 LOC114045424 ENSVURP00010014402 ENSVURP00010014402 ENSVURP00010014299 ENSVURP00010014299 ENSVURP00010014291 ENSVURP00010014291 ENSVURP00010014276 ENSVURP00010014276 KIT KIT PDGFRA PDGFRA FGFR1 FGFR1 ENSVURP00010013035 ENSVURP00010013035 NRAS NRAS CSDE1 CSDE1 ENSVURP00010011447 ENSVURP00010011447 PIK3CB PIK3CB PGAM2 PGAM2 MAPK3 MAPK3 PDGFRB PDGFRB LOC114049642 LOC114049642 TIGAR TIGAR NTRK3 NTRK3 IDH2 IDH2 ENSVURP00010008839 ENSVURP00010008839 PFKM PFKM ERBB2 ERBB2 SCO2 SCO2 AKT1 AKT1 HRAS HRAS SIRT3 SIRT3 IDH1 IDH1 ENSVURP00010019784 ENSVURP00010019784 PARP6 PARP6 PKM PKM KRAS KRAS SLC16A3 SLC16A3 LOC114049642-2 LOC114049642-2 LDHB LDHB ENSVURP00010021924 ENSVURP00010021924 ENSVURP00010022176 ENSVURP00010022176 PFKL PFKL PGAM1 PGAM1 LOC114024909 LOC114024909 MAP2K1 MAP2K1 ENSVURP00010022891 ENSVURP00010022891 ENSVURP00010022990 ENSVURP00010022990 FGFR2 FGFR2 HIF1A HIF1A G6PD G6PD SLC2A1 SLC2A1 PIK3R1 PIK3R1 PDK1 PDK1 MET MET
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
FLT3Uncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (999 aa)
SLC7A5Solute carrier family 7 member 5. (491 aa)
FGFR3Fibroblast growth factor receptor. (851 aa)
ENSVURP00010028054Uncharacterized protein. (54 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (349 aa)
ENSVURP00010029530Uncharacterized protein. (538 aa)
ENSVURP00010029927Uncharacterized protein. (64 aa)
ENSVURP00010030368L-lactate dehydrogenase. (207 aa)
GLS2Glutaminase 2. (595 aa)
PFKPATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (811 aa)
ENSVURP00010031228Ldh_1_C domain-containing protein. (93 aa)
ENSVURP00010031265Uncharacterized protein. (155 aa)
ENSVURP00010031269annotation not available (155 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
PIK3CDUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1075 aa)
SIRT6Deacetylase sirtuin-type domain-containing protein. (345 aa)
LDHAL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (333 aa)
MAP2K2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (400 aa)
PARP8Poly [ADP-ribose] polymerase. (1006 aa)
HK3Uncharacterized protein. (913 aa)
GCKPhosphotransferase. (450 aa)
ENSVURP00010003442Uncharacterized protein; Belongs to the LDH/MDH superfamily. (343 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (370 aa)
ENSVURP00010005096Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
LDHCL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (300 aa)
ENSVURP00010000232Uncharacterized protein. (48 aa)
ENSVURP00010019760Uncharacterized protein. (152 aa)
PIK3R2Uncharacterized protein. (738 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (361 aa)
HKDC1Uncharacterized protein. (917 aa)
HK1Uncharacterized protein. (919 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
NTRK1Tyrosine-protein kinase receptor. (743 aa)
EGFRReceptor protein-tyrosine kinase. (1214 aa)
ENSVURP00010017868Ldh_1_N domain-containing protein. (89 aa)
ENSVURP00010017759annotation not available (448 aa)
RAF1Uncharacterized protein. (667 aa)
SLC2A2MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (519 aa)
TNIKUncharacterized protein. (1716 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (395 aa)
HK2Uncharacterized protein. (917 aa)
LOC114030664Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (448 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (317 aa)
ENSVURP00010014654Uncharacterized protein. (536 aa)
LOC114045424Uncharacterized protein; Belongs to the LDH/MDH superfamily. (319 aa)
ENSVURP00010014402annotation not available (113 aa)
ENSVURP00010014299Ldh_1_N domain-containing protein. (113 aa)
ENSVURP00010014291annotation not available (318 aa)
ENSVURP00010014276Uncharacterized protein. (318 aa)
KITUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (997 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1086 aa)
FGFR1Fibroblast growth factor receptor. (822 aa)
ENSVURP00010013035Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (387 aa)
NRASUncharacterized protein. (189 aa)
CSDE1Uncharacterized protein. (847 aa)
ENSVURP00010011447Ldh_1_N domain-containing protein. (108 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1052 aa)
PGAM2Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (255 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (380 aa)
PDGFRBUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1101 aa)
LOC114049642Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TIGARUncharacterized protein. (271 aa)
NTRK3Tyrosine-protein kinase receptor. (850 aa)
IDH2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (455 aa)
ENSVURP00010008839Protein-serine/threonine kinase. (77 aa)
PFKMATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (782 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
SCO2SCO cytochrome c oxidase assembly protein 2. (252 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
HRASUncharacterized protein. (189 aa)
SIRT3NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (415 aa)
IDH1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (414 aa)
ENSVURP00010019784Uncharacterized protein. (218 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (611 aa)
KRASUncharacterized protein. (189 aa)
SLC16A3MFS domain-containing protein. (472 aa)
LOC114049642-2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LDHBL-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
ENSVURP00010021924Ldh_1_N domain-containing protein. (161 aa)
ENSVURP00010022176L-lactate dehydrogenase. (218 aa)
PFKLUncharacterized protein. (726 aa)
PGAM1Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (278 aa)
LOC114024909Uncharacterized protein. (464 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (393 aa)
ENSVURP00010022891ANK_REP_REGION domain-containing protein. (93 aa)
ENSVURP00010022990Ldh_1_C domain-containing protein. (103 aa)
FGFR2Fibroblast growth factor receptor. (840 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (814 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (587 aa)
SLC2A1MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (491 aa)
PIK3R1Uncharacterized protein. (725 aa)
PDK1Protein-serine/threonine kinase. (429 aa)
METUncharacterized protein. (1379 aa)
Your Current Organism:
Vombatus ursinus
NCBI taxonomy Id: 29139
Other names: V. ursinus, coarse-haired wombat, common wombat
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