STRINGSTRING
AOI80984.1 AOI80984.1 gcvP gcvP gcvT gcvT Gph Gph eda eda glcF glcF glcE glcE AOI81564.1 AOI81564.1 glyA glyA AOI81842.1 AOI81842.1 AOI81843.1 AOI81843.1 ghrB_2 ghrB_2 AOI81915.1 AOI81915.1 lpdA lpdA GhrB GhrB phbB-1 phbB-1 AOI82665.1 AOI82665.1 gcl gcl hyi hyi garR_1 garR_1 AOI82774.1 AOI82774.1 AOI82795.1 AOI82795.1 AceA AceA AceB AceB LpdA LpdA glnA glnA AOI83063.1 AOI83063.1 HutG HutG Acs Acs PhbB-1 PhbB-1 AOI84209.1 AOI84209.1 purU purU puuA_2 puuA_2 AOI84925.1 AOI84925.1 acnA acnA mdh mdh gltA gltA AOI85168.1 AOI85168.1 fdnG fdnG fdnH fdnH fdoI fdoI AOI85716.1 AOI85716.1 OxdD OxdD acnB acnB AOI86289.1 AOI86289.1 AOI86299.1 AOI86299.1 AOI86381.1 AOI86381.1 AOI86469.1 AOI86469.1 purU-2 purU-2 glyA-2 glyA-2 Acs-2 Acs-2 AOI86976.1 AOI86976.1 glcF-2 glcF-2 glcB glcB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AOI80984.1Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (364 aa)
gcvPGlycine dehydrogenase (aminomethyl-transferring); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (975 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (372 aa)
GphPhosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (254 aa)
eda2-dehydro-3-deoxyphosphogluconate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
glcFGlycolate oxidase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
glcEGlycolate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
AOI81564.1Glycolate oxidase subunit GlcD; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (415 aa)
AOI81842.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (983 aa)
AOI81843.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
ghrB_2D-glycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
AOI81915.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
lpdACatalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (476 aa)
GhrBD-glycerate dehydrogenase; Catalyzes the formation of glycolate from glyoxylate and glycerate from hydroxypyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (321 aa)
phbB-1beta-ketoacyl-ACP reductase; Catalyzes the formation of 3-hydroxybutyryl-CoA from acetoacetyl-CoA in polyhydroxyalkanoate synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
AOI82665.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
gclGlyoxylate carboligase; Catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (591 aa)
hyiHydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the hyi family. (269 aa)
garR_12-hydroxy-3-oxopropionate reductase; NADH-dependent; catalyzed the reversible formation of glycerate from tartronate semialdehyde; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
AOI82774.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
AOI82795.1Glycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (381 aa)
AceAIsocitrate lyase; Catalyzes the reversible formation of glyoxylate and succinate from isocitrate; glyoxylate bypass pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
AceBMalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the malate synthase family. (530 aa)
LpdADihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (586 aa)
glnAForms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
AOI83063.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (445 aa)
HutGN-formylglutamate deformylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
AcsAcetyl-coenzyme A synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
PhbB-1beta-ketoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
AOI84209.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
puuA_2Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (445 aa)
AOI84925.1Tartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (905 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (433 aa)
AOI85168.1Sulfate ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
fdnGFormate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (810 aa)
fdnHFormate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
fdoIFormate dehydrogenase; Cytochrome b556(FDO) component; heme containing; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
AOI85716.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
OxdDCupin; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
acnBAconitate hydratase B; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (861 aa)
AOI86289.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (448 aa)
AOI86299.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
AOI86381.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (568 aa)
AOI86469.1Isocitrate lyase; Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; Derived by automated computational analysis using gene prediction method: Protein Homology. (527 aa)
purU-2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (295 aa)
glyA-2Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (424 aa)
Acs-2Acetyl-coenzyme A synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
AOI86976.1Glycolate oxidase subunit GlcD; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
glcF-2Glycolate oxidase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (724 aa)
Your Current Organism:
Burkholderia cepacia
NCBI taxonomy Id: 292
Other names: ATCC 25416, B. cepacia, Burkholderia cepacia genomovar I, Burkholderia sp. Bp7081, Burkholderia sp. Bp7091, Burkholderia sp. Bp7098, Burkholderia sp. Bp7108, Burkholderia sp. Bp7432, Burkholderia sp. LK29, Burkholderia sp. NCIM 5465, CCUG 12691, CCUG 13226, CFBP 2227, CIP 80.24, DSM 7288, ICMP 5796, IFO 14074, JCM 5964, NBRC 14074, NCCB 76047, NCPPB 2993, NCTC 10743, NRRL B-14810, Pseudomonas cepacia, Pseudomonas kingii, Pseudomonas multivorans, strain 717-ICPB 25, strain Ballard 717
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