node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABF63191.1 | ABF63669.1 | TM1040_0458 | TM1040_0936 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | MazG family protein. | 0.900 |
ABF63191.1 | coaD | TM1040_0458 | TM1040_1109 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Coenzyme A biosynthesis protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. | 0.959 |
ABF63191.1 | coaE | TM1040_0458 | TM1040_2859 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.567 |
ABF63191.1 | coaX | TM1040_0458 | TM1040_0762 | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.938 |
ABF63607.1 | ABF63608.1 | TM1040_0874 | TM1040_0875 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
ABF63607.1 | ABF64263.1 | TM1040_0874 | TM1040_1530 | Acetolactate synthase, small subunit. | Thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 0.994 |
ABF63607.1 | ABF64665.1 | TM1040_0874 | TM1040_1932 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.994 |
ABF63607.1 | ilvC | TM1040_0874 | TM1040_2303 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.998 |
ABF63607.1 | ilvD | TM1040_0874 | TM1040_2486 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.843 |
ABF63607.1 | ilvE | TM1040_0874 | TM1040_2926 | Acetolactate synthase, small subunit. | Branched chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.628 |
ABF63608.1 | ABF63607.1 | TM1040_0875 | TM1040_0874 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
ABF63608.1 | ABF64263.1 | TM1040_0875 | TM1040_1530 | Acetolactate synthase, large subunit. | Thiamine pyrophosphate enzyme-like TPP-binding; Belongs to the TPP enzyme family. | 0.924 |
ABF63608.1 | ABF64665.1 | TM1040_0875 | TM1040_1932 | Acetolactate synthase, large subunit. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.924 |
ABF63608.1 | ilvC | TM1040_0875 | TM1040_2303 | Acetolactate synthase, large subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.993 |
ABF63608.1 | ilvD | TM1040_0875 | TM1040_2486 | Acetolactate synthase, large subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.952 |
ABF63608.1 | ilvE | TM1040_0875 | TM1040_2926 | Acetolactate synthase, large subunit. | Branched chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.473 |
ABF63669.1 | ABF63191.1 | TM1040_0936 | TM1040_0458 | MazG family protein. | Phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. | 0.900 |
ABF63669.1 | coaE | TM1040_0936 | TM1040_2859 | MazG family protein. | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. | 0.906 |
ABF63669.1 | coaX | TM1040_0936 | TM1040_0762 | MazG family protein. | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis; Belongs to the type III pantothenate kinase family. | 0.904 |
ABF64230.1 | ABF64233.1 | TM1040_1497 | TM1040_1500 | Dihydropyrimidinase. | Dihydropyrimidine dehydrogenase (NADP+) / dihydrouracil dehydrogenase (NAD+) / dihydroorotate oxidase B, catalytic subunit. | 0.998 |