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| | STH1014 | Acetolactate synthase-like TPP-requiring enzyme. (551 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (284 aa) |
| | STH1186 | methylmalonyl-CoA mutase, N-terminal domain. (556 aa) |
| | STH1187 | methylmalonyl-CoA mutase, C-terminal domain. (131 aa) |
| | STH1188 | Putative lactoylglutathione lyase. (151 aa) |
| | STH1189 | acetyl-CoA carboxylase alpha subunit. (513 aa) |
| | STH1190 | acetyl-CoA carboxylase, biotin carboxyl carrier protein. (154 aa) |
| | STH1191 | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | STH1196 | Glutamate/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (417 aa) |
| | STH1316 | 2-oxoacid:ferredoxin oxidoreductase beta subunit. (287 aa) |
| | STH1317 | 2-oxoacid:ferredoxin oxidoreductase alpha subunit. (609 aa) |
| | STH1319 | Malate oxidoreductase. (476 aa) |
| | STH1330 | D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. (281 aa) |
| | STH1513 | Putative lipoate-protein ligase. (201 aa) |
| | STH1572 | Conserved hypothetical protein. (68 aa) |
| | STH1579 | Putative propionyl-CoA carboxylase beta subunit. (508 aa) |
| | STH1827 | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (355 aa) |
| | STH1830 | Leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (357 aa) |
| | STH1872 | 8-amino-7-oxononanoate synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (392 aa) |
| | tdh | Threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (351 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | lipM | Putative lipoate protein ligase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation. (274 aa) |
| | gcvPB | Glycine cleavage system protein P subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (486 aa) |
| | gcvPA | Glycine cleavage system protein P subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (458 aa) |
| | gcvH | Glycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (128 aa) |
| | gcvT | Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (375 aa) |
| | STH1946 | 3-isopropylmalate dehydrogenase. (357 aa) |
| | STH198 | Glutamine synthetase. (471 aa) |
| | STH1988 | 2-isopropylmalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (556 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (192 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (481 aa) |
| | lipA | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (320 aa) |
| | STH2160 | Branched-chain alpha-keto acid dehydrogenase E2. (459 aa) |
| | STH2161 | Branched-chain alpha-keto acid dehydrogenase E1 beta subunit. (327 aa) |
| | STH2162 | Branched-chain alpha-keto acid dehydrogenase E1 alpha subunit. (352 aa) |
| | STH2163 | Branched-chain alpha-keto acid dehydrogenase E3. (471 aa) |
| | STH2182 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1148 aa) |
| | STH220 | Conserved hypothetical protein. (223 aa) |
| | STH221 | Putative ferredoxin. (73 aa) |
| | STH222 | 2-oxoglutarate oxidoreductase alpha subunit. (355 aa) |
| | STH223 | 2-oxoglutarate oxidoreductase beta subunit. (253 aa) |
| | STH224 | 2-oxoglutarate oxidoreductase gamma subunit. (185 aa) |
| | STH230 | Glutamate synthase large subunit. (1552 aa) |
| | STH2344 | Tartrate dehydrogenase. (359 aa) |
| | STH2403 | Threonine aldolase. (346 aa) |
| | STH2464 | Conserved hypothetical protein. (403 aa) |
| | STH2465 | methylmalonyl-CoA mutase C-terminal domain. (135 aa) |
| | STH2466 | methylmalonyl-CoA mutase N-terminal domain. (534 aa) |
| | STH2526 | Conserved hypothetical protein; Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate. (192 aa) |
| | sucD | succinyl-CoA synthetase alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa) |
| | sucC | succinyl-CoA synthetase beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (373 aa) |
| | STH2534 | Malate dehydrogenase. (417 aa) |
| | STH2535 | Fumarate hydratase subunit B. (197 aa) |
| | STH2536 | Fumarate hydratase subunit A. (280 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (425 aa) |
| | proB | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (262 aa) |
| | STH2542 | Citrate synthase; Belongs to the citrate synthase family. (439 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (315 aa) |
| | STH2544 | Isocitrate dehydrogenase. (421 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | STH2637 | Succinate dehydrogenase membrane subunit. (140 aa) |
| | STH2638 | Succinate dehydrogenase membrane subunit. (114 aa) |
| | STH2639 | Succinate dehydrogenase flavoprotein subunit. (573 aa) |
| | STH2640 | Succinate dehydrogenase iron-sulfur protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (243 aa) |
| | STH2641 | Fumarate hydratase subunit A. (280 aa) |
| | STH2642 | Fumarate hydratase subunit B. (191 aa) |
| | STH2684 | Acetolactate synthase large subunit. (571 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (565 aa) |
| | ilvE | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (291 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (523 aa) |
| | STH2688 | Ketol-acid reductoisomerase. (275 aa) |
| | STH2689 | Acetolactate synthase small subunit. (177 aa) |
| | STH2741 | 1-pyrroline-5 carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (520 aa) |
| | STH2805 | Glutamate/leucine dehydrogenase; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (438 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (368 aa) |
| | STH3164 | Aconitase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (890 aa) |
| | STH3167 | Pyruvate flavodoxin dehydrogenase. (1183 aa) |
| | STH3174 | Succinate dehydrogenase iron-sulfur protein. (251 aa) |
| | STH3175 | Succinate dehydrogenase flavoprotein subunit. (593 aa) |
| | STH3176 | Succinate dehydrogenase cytochrome b558 subunit. (211 aa) |
| | STH3243 | Threonine dehydratase. (410 aa) |
| | STH3262 | Pyruvate ferredoxin oxidoreductase alpha-beta subunit. (755 aa) |
| | STH3264 | Pyruvate ferredoxin oxidoreductase gamma-delta subunit. (343 aa) |
| | pdhA | Pyruvate dehydrogenase E1 alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (368 aa) |
| | STH412 | Pyruvate dehydrogenase E1 beta subunit. (326 aa) |
| | STH413 | Pyruvate dehydrogenase E2; Dihydrolipoamide acetyltransferase. (450 aa) |
| | STH414 | Pyruvate dehydrogenase E3; Dihydrolipoamide dehydrogenase. (470 aa) |
| | STH561 | Lipoate-protein ligase. (327 aa) |
| | STH583 | Branched-chain alpha-keto acid dehydrogenase E1 alpha subunit. (334 aa) |
| | STH584 | Conserved hypothetical protein. (262 aa) |
| | STH616 | 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa) |
| | STH645 | Proline dehydrogenase. (305 aa) |
| | STH646 | 1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (514 aa) |
| | STH722 | Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (477 aa) |
| | acsA | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (654 aa) |
| | STH938 | 3-hydroxyisobutyrate dehydrogenase. (294 aa) |
