STRINGSTRING
STH1872 STH1872 glyA glyA STH1925 STH1925 STH258 STH258 STH2362 STH2362 STH2363 STH2363 STH2390 STH2390 STH2465 STH2465 STH2466 STH2466 STH943 STH943 STH2500 STH2500 STH2501 STH2501 STH2557 STH2557 STH223 STH223 STH2681 STH2681 STH2684 STH2684 STH2754 STH2754 STH2760 STH2760 STH2782 STH2782 hemL hemL hisC hisC argD argD alr alr STH3167 STH3167 STH3192 STH3192 STH322 STH322 STH3243 STH3243 STH3262 STH3262 STH37 STH37 STH832 STH832 STH768 STH768 STH641 STH641 STH616 STH616 STH553 STH553 STH38 STH38 STH1000 STH1000 STH1014 STH1014 STH1030 STH1030 STH1052 STH1052 STH1186 STH1186 STH1187 STH1187 STH1227 STH1227 STH1274 STH1274 STH1316 STH1316 STH1330 STH1330 lysA lysA dxs dxs
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STH18728-amino-7-oxononanoate synthetase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (392 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
STH1925Histidinol-phosphate aminotransferase. (339 aa)
STH258Methionine synthase I, cobalamin-binding domain. (543 aa)
STH2362Cystathionine beta-lyase. (75 aa)
STH2363Cystathionine gamma-synthase. (359 aa)
STH2390Cysteine desulfurase. (402 aa)
STH2465methylmalonyl-CoA mutase C-terminal domain. (135 aa)
STH2466methylmalonyl-CoA mutase N-terminal domain. (534 aa)
STH943Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (469 aa)
STH25005-methyltetrahydrofolate S-homocysteine methyltransferase. (859 aa)
STH2501Conserved hypothetical protein. (197 aa)
STH2557Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (399 aa)
STH2232-oxoglutarate oxidoreductase beta subunit. (253 aa)
STH2681O-acetylhomoserine sulfhydrylase. (435 aa)
STH2684Acetolactate synthase large subunit. (571 aa)
STH2754Class I aminotransferase protein. (489 aa)
STH2760Ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (776 aa)
STH2782O-acetylhomoserine sulfhydrylase. (426 aa)
hemLGlutamate-1-semialdehyde aminotransferase. (433 aa)
hisCHistidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (361 aa)
argDN-acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (407 aa)
alrAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (377 aa)
STH3167Pyruvate flavodoxin dehydrogenase. (1183 aa)
STH3192Glutamate formiminotransferase. (290 aa)
STH322Ribonucleoside-diphosphate reductase alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (782 aa)
STH3243Threonine dehydratase. (410 aa)
STH3262Pyruvate ferredoxin oxidoreductase alpha-beta subunit. (755 aa)
STH37Lysine 5,6-aminomutase alpha subunit. (520 aa)
STH832Cystathionine gamma-lyase. (401 aa)
STH768Putative class-III aminotransferase. (875 aa)
STH641Cysteine desulfurase. (380 aa)
STH6164-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
STH553Putative alanine racemase. (383 aa)
STH38Lysine 5,6-aminomutase beta subunit. (245 aa)
STH1000Cystathionine gamma-lyase. (395 aa)
STH1014Acetolactate synthase-like TPP-requiring enzyme. (551 aa)
STH1030Aspartate aminotransferase. (397 aa)
STH1052Thiamin pyrophosphokinase. (216 aa)
STH1186methylmalonyl-CoA mutase, N-terminal domain. (556 aa)
STH1187methylmalonyl-CoA mutase, C-terminal domain. (131 aa)
STH1227Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (230 aa)
STH1274Putative sphingosine-1-phosphate lyase; Belongs to the group II decarboxylase family. (507 aa)
STH13162-oxoacid:ferredoxin oxidoreductase beta subunit. (287 aa)
STH1330D-alanine aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction. (281 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (443 aa)
dxs1-deoxy-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (648 aa)
Your Current Organism:
Symbiobacterium thermophilum
NCBI taxonomy Id: 292459
Other names: S. thermophilum IAM 14863, Symbiobacterium thermophilum IAM 14863, Symbiobacterium thermophilum str. IAM 14863, Symbiobacterium thermophilum strain IAM 14863
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