STRINGSTRING
GcvT GcvT gcvH gcvH gcvPA gcvPA CD943_11890 CD943_11890 purT purT glyA glyA folD folD CD943_14470 CD943_14470 CD943_14465 CD943_14465 PutA PutA glnA glnA CD943_05510 CD943_05510 glyA-2 glyA-2 CD943_07530 CD943_07530 CD943_08655 CD943_08655 CD943_08940 CD943_08940 thyA thyA CD943_00505 CD943_00505 proA proA proB proB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GcvTUnannotated protein. (370 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (121 aa)
gcvPAUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa)
CD943_11890Unannotated protein. (525 aa)
purTUnannotated protein; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (397 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (307 aa)
CD943_14470Unannotated protein. (477 aa)
CD943_14465Unannotated protein. (1508 aa)
PutAUnannotated protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1036 aa)
glnAUnannotated protein. (469 aa)
CD943_05510Unannotated protein. (1127 aa)
glyA-2Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
CD943_07530Unannotated protein; Belongs to the folylpolyglutamate synthase family. (428 aa)
CD943_08655Unannotated protein. (1620 aa)
CD943_08940Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (420 aa)
thyAUnannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (285 aa)
CD943_00505Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (175 aa)
proAUnannotated protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (424 aa)
proBUnannotated protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (389 aa)
Your Current Organism:
Brevundimonas diminuta
NCBI taxonomy Id: 293
Other names: AJ 2067, ATCC 11568, B. diminuta, BCRC 11894, Bacterium parvulum, CCEB 513, CCRC 11894, CCRC:11894, CECT 317, CIP 63.27, DSM 7234, IAM 12691, IFO 12697, IMET 10409, JCM 2788, LMG 2088, LMG 2089, LMG:2088, LMG:2089, NBRC 12697, NCAIM B.01118, NCCB 76050, NCIB 9393, NCIMB 9393, NCTC 8545, Pseudomonas diminuta
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