STRINGSTRING
CD943_12765 CD943_12765 ilvE ilvE CD943_11800 CD943_11800 CD943_11785 CD943_11785 CD943_11635 CD943_11635 CD943_11055 CD943_11055 argB argB CD943_11045 CD943_11045 dapD dapD dapA dapA CD943_00885 CD943_00885 argC argC argJ argJ CD943_10365 CD943_10365 CD943_10490 CD943_10490 leuB leuB CD943_02720 CD943_02720 ilvA ilvA CD943_06500 CD943_06500 argH argH lysA lysA argF argF CD943_07315 CD943_07315 dapE dapE asd asd dapF dapF argG argG CD943_09105 CD943_09105 dapB dapB leuB-2 leuB-2 leuD leuD leuC leuC ilvE_2 ilvE_2 CD943_09595 CD943_09595 CD943_09600 CD943_09600 CD943_09605 CD943_09605 ilvC ilvC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD943_12765Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (364 aa)
ilvEUnannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (247 aa)
CD943_11800Unannotated protein. (482 aa)
CD943_11785Unannotated protein. (578 aa)
CD943_11635Unannotated protein. (399 aa)
CD943_11055Unannotated protein. (734 aa)
argBUnannotated protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (352 aa)
CD943_11045Unannotated protein. (237 aa)
dapDUnannotated protein; Belongs to the transferase hexapeptide repeat family. (289 aa)
dapAUnannotated protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
CD943_00885Unannotated protein. (338 aa)
argCUnannotated protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (311 aa)
argJUnannotated protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (460 aa)
CD943_10365Unannotated protein; Belongs to the aspartokinase family. (429 aa)
CD943_10490Unannotated protein. (400 aa)
leuBUnannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (370 aa)
CD943_02720Unannotated protein. (428 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (534 aa)
CD943_06500Unannotated protein; Belongs to the TPP enzyme family. (554 aa)
argHUnannotated protein. (441 aa)
lysAUnannotated protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (424 aa)
argFUnannotated protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (305 aa)
CD943_07315Unannotated protein. (396 aa)
dapEUnannotated protein; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (397 aa)
asdUnannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
dapFUnannotated protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (295 aa)
argGUnannotated protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (409 aa)
CD943_09105Unannotated protein. (324 aa)
dapBUnannotated protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (249 aa)
leuB-2Unannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (371 aa)
leuDUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (200 aa)
leuCUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (486 aa)
ilvE_2Unannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (324 aa)
CD943_09595Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (415 aa)
CD943_09600Unannotated protein. (85 aa)
CD943_09605Unannotated protein. (568 aa)
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (294 aa)
Your Current Organism:
Brevundimonas diminuta
NCBI taxonomy Id: 293
Other names: AJ 2067, ATCC 11568, B. diminuta, BCRC 11894, Bacterium parvulum, CCEB 513, CCRC 11894, CCRC:11894, CECT 317, CIP 63.27, DSM 7234, IAM 12691, IFO 12697, IMET 10409, JCM 2788, LMG 2088, LMG 2089, LMG:2088, LMG:2089, NBRC 12697, NCAIM B.01118, NCCB 76050, NCIB 9393, NCIMB 9393, NCTC 8545, Pseudomonas diminuta
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