STRINGSTRING
cysK cysK pyk pyk adhT adhT CD943_11975 CD943_11975 fbp fbp CD943_11800 CD943_11800 thrB thrB CD943_11785 CD943_11785 CD943_11635 CD943_11635 hapE hapE CD943_04060 CD943_04060 CD943_03675 CD943_03675 CD943_03645 CD943_03645 pgk pgk gap gap tkt tkt AceA AceA CD943_03185 CD943_03185 ubiX ubiX CD943_02990 CD943_02990 glcB glcB glyA glyA rpiA rpiA folD folD metF metF tpiA tpiA CD943_14880 CD943_14880 gltX gltX gltA gltA CD943_14470 CD943_14470 CD943_14465 CD943_14465 CD943_14280 CD943_14280 cysE cysE pckG pckG dapD dapD CD943_11025 CD943_11025 pdxH pdxH glnA glnA dapA dapA eno eno acoA acoA CD943_16275 CD943_16275 CD943_16285 CD943_16285 lpdA lpdA CD943_16300 CD943_16300 GCA_000988015_01188 GCA_000988015_01188 gltX-2 gltX-2 accA accA CD943_00885 CD943_00885 SseA SseA CD943_01460 CD943_01460 HemB HemB CD943_01530 CD943_01530 accB accB accC accC CD943_10365 CD943_10365 CD943_10570 CD943_10570 CD943_09935 CD943_09935 CD943_11200 CD943_11200 fabG_7 fabG_7 prs prs mce mce mutB mutB CD943_02580 CD943_02580 CD943_02585 CD943_02585 CD943_02705 CD943_02705 CD943_02720 CD943_02720 CD943_05165 CD943_05165 gabD gabD acs acs CD943_05565 CD943_05565 fghA fghA CD943_05620 CD943_05620 CD943_06065 CD943_06065 CD943_06120 CD943_06120 zwf zwf edd edd glk glk hmgA hmgA CD943_06225 CD943_06225 glyA-2 glyA-2 lysA lysA lpdA-2 lpdA-2 tal tal lpdA-3 lpdA-3 fadA_1 fadA_1 CD943_07280 CD943_07280 CD943_07315 CD943_07315 dapE dapE accD accD CD943_07625 CD943_07625 gpmA gpmA CD943_07715 CD943_07715 CD943_07835 CD943_07835 CD943_07860 CD943_07860 OdhB OdhB CD943_07885 CD943_07885 sucD sucD sucC sucC CD943_07935 CD943_07935 CD943_08015 CD943_08015 CD943_08025 CD943_08025 pgi pgi asd asd mdh mdh sdhC sdhC CD943_08180 CD943_08180 CD943_08185 CD943_08185 CD943_08190 CD943_08190 dapF dapF CD943_08260 CD943_08260 acnA acnA CD943_08655 CD943_08655 CD943_08940 CD943_08940 hemC hemC GCA_000988015_02772 GCA_000988015_02772 GCA_000988015_02816 GCA_000988015_02816 fumC fumC CD943_13590 CD943_13590 CD943_09245 CD943_09245 dapB dapB ppc ppc cysQ cysQ fadB2 fadB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cysKUnannotated protein. (329 aa)
pykUnannotated protein; Belongs to the pyruvate kinase family. (487 aa)
adhTUnannotated protein. (344 aa)
CD943_11975Unannotated protein; Belongs to the aldehyde dehydrogenase family. (505 aa)
fbpUnannotated protein; Belongs to the FBPase class 1 family. (322 aa)
CD943_11800Unannotated protein. (482 aa)
thrBUnannotated protein; Belongs to the pseudomonas-type ThrB family. (320 aa)
CD943_11785Unannotated protein. (578 aa)
CD943_11635Unannotated protein. (399 aa)
hapEUnannotated protein. (458 aa)
CD943_04060Unannotated protein; Belongs to the PEP-utilizing enzyme family. (896 aa)
CD943_03675Unannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (386 aa)
CD943_03645Unannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (398 aa)
gapUnannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
tktUnannotated protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
AceAUnannotated protein. (425 aa)
CD943_03185Unannotated protein; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (629 aa)
ubiXUnannotated protein; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (205 aa)
CD943_02990Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
glcBUnannotated protein; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
rpiAUnannotated protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (227 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (307 aa)
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (315 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
CD943_14880Unannotated protein. (119 aa)
gltXUnannotated protein; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (471 aa)
gltAUnannotated protein; Belongs to the citrate synthase family. (433 aa)
CD943_14470Unannotated protein. (477 aa)
CD943_14465Unannotated protein. (1508 aa)
CD943_14280Unannotated protein; Belongs to the 4-oxalocrotonate tautomerase family. (72 aa)
cysEUnannotated protein. (273 aa)
pckGUnannotated protein; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (614 aa)
dapDUnannotated protein; Belongs to the transferase hexapeptide repeat family. (289 aa)
CD943_11025Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
pdxHUnannotated protein; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (222 aa)
glnAUnannotated protein. (469 aa)
dapAUnannotated protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
acoAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (342 aa)
CD943_16275Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (449 aa)
CD943_16285Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (418 aa)
lpdAUnannotated protein. (468 aa)
CD943_16300Unannotated protein. (334 aa)
GCA_000988015_01188Unannotated protein. (428 aa)
gltX-2Unannotated protein; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (444 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
CD943_00885Unannotated protein. (338 aa)
SseAUnannotated protein. (281 aa)
CD943_01460Unannotated protein. (350 aa)
HemBUnannotated protein; Belongs to the ALAD family. (333 aa)
CD943_01530Unannotated protein. (502 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
CD943_10365Unannotated protein; Belongs to the aspartokinase family. (429 aa)
CD943_10570Unannotated protein. (335 aa)
CD943_09935Unannotated protein. (119 aa)
CD943_11200Unannotated protein. (356 aa)
fabG_7Unannotated protein. (241 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa)
mceUnannotated protein. (140 aa)
mutBUnannotated protein. (719 aa)
CD943_02580Unannotated protein. (658 aa)
CD943_02585Unannotated protein. (511 aa)
CD943_02705Unannotated protein; Belongs to the aldehyde dehydrogenase family. (481 aa)
CD943_02720Unannotated protein. (428 aa)
CD943_05165Unannotated protein. (153 aa)
gabDUnannotated protein; Belongs to the aldehyde dehydrogenase family. (481 aa)
acsUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa)
CD943_05565Unannotated protein; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa)
fghAUnannotated protein; Serine hydrolase involved in the detoxification of formaldehyde. (277 aa)
CD943_05620Unannotated protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa)
CD943_06065Unannotated protein. (265 aa)
CD943_06120Unannotated protein. (404 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (484 aa)
eddUnannotated protein; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (629 aa)
glkUnannotated protein; Belongs to the bacterial glucokinase family. (322 aa)
hmgAUnannotated protein; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (430 aa)
CD943_06225Unannotated protein. (223 aa)
glyA-2Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
lysAUnannotated protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (424 aa)
lpdA-2Unannotated protein. (465 aa)
talUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
lpdA-3Unannotated protein. (470 aa)
fadA_1Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
CD943_07280Unannotated protein. (730 aa)
CD943_07315Unannotated protein. (396 aa)
dapEUnannotated protein; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (397 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (299 aa)
CD943_07625Unannotated protein; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
gpmAUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (237 aa)
CD943_07715Unannotated protein. (499 aa)
CD943_07835Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (328 aa)
CD943_07860Unannotated protein. (396 aa)
OdhBUnannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (501 aa)
CD943_07885Unannotated protein. (1006 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (396 aa)
CD943_07935Unannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa)
CD943_08015Unannotated protein. (299 aa)
CD943_08025Unannotated protein. (217 aa)
pgiUnannotated protein; Belongs to the GPI family. (534 aa)
asdUnannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (348 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sdhCUnannotated protein. (153 aa)
CD943_08180Unannotated protein. (131 aa)
CD943_08185Unannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (594 aa)
CD943_08190Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (265 aa)
dapFUnannotated protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (295 aa)
CD943_08260Unannotated protein. (768 aa)
acnAUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
CD943_08655Unannotated protein. (1620 aa)
CD943_08940Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (420 aa)
hemCUnannotated protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (314 aa)
GCA_000988015_02772Unannotated protein. (323 aa)
GCA_000988015_02816Unannotated protein. (403 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
CD943_13590Unannotated protein. (410 aa)
CD943_09245Unannotated protein. (301 aa)
dapBUnannotated protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (249 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (901 aa)
cysQUnannotated protein; Converts adenosine-3',5'-bisphosphate (PAP) to AMP. Belongs to the inositol monophosphatase superfamily. CysQ family. (265 aa)
fadB2Unannotated protein. (292 aa)
Your Current Organism:
Brevundimonas diminuta
NCBI taxonomy Id: 293
Other names: AJ 2067, ATCC 11568, B. diminuta, BCRC 11894, Bacterium parvulum, CCEB 513, CCRC 11894, CCRC:11894, CECT 317, CIP 63.27, DSM 7234, IAM 12691, IFO 12697, IMET 10409, JCM 2788, LMG 2088, LMG 2089, LMG:2088, LMG:2089, NBRC 12697, NCAIM B.01118, NCCB 76050, NCIB 9393, NCIMB 9393, NCTC 8545, Pseudomonas diminuta
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