STRINGSTRING
cysK cysK pyk pyk fbp fbp GcvT GcvT gcvH gcvH gcvPA gcvPA CD943_11890 CD943_11890 CD943_04060 CD943_04060 CD943_03675 CD943_03675 CD943_03645 CD943_03645 pgk pgk gap gap tkt tkt AceA AceA CD943_03185 CD943_03185 CD943_02990 CD943_02990 glcB glcB glyA glyA rpiA rpiA folD folD metF metF tpiA tpiA gltA gltA cysE cysE CD943_11025 CD943_11025 eno eno acoA acoA CD943_16275 CD943_16275 CD943_16285 CD943_16285 lpdA lpdA CD943_16300 CD943_16300 GCA_000988015_01188 GCA_000988015_01188 accA accA CD943_01530 CD943_01530 accB accB accC accC CD943_10115 CD943_10115 CD943_10490 CD943_10490 fabG_7 fabG_7 prs prs mce mce mutB mutB CD943_02580 CD943_02580 CD943_02585 CD943_02585 mmsA mmsA CD943_05165 CD943_05165 acs acs CD943_05565 CD943_05565 fghA fghA CD943_05620 CD943_05620 ilvA ilvA zwf zwf edd edd glk glk CD943_06225 CD943_06225 glyA-2 glyA-2 lpdA-2 lpdA-2 tal tal lpdA-3 lpdA-3 fadA_1 fadA_1 CD943_07280 CD943_07280 accD accD gpmA gpmA OdhB OdhB CD943_07885 CD943_07885 sucD sucD sucC sucC CD943_07935 CD943_07935 pgi pgi mdh mdh sdhC sdhC CD943_08180 CD943_08180 CD943_08185 CD943_08185 CD943_08190 CD943_08190 CD943_08260 CD943_08260 acnA acnA CD943_09105 CD943_09105 GCA_000988015_02772 GCA_000988015_02772 fumC fumC ppc ppc fadB2 fadB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cysKUnannotated protein. (329 aa)
pykUnannotated protein; Belongs to the pyruvate kinase family. (487 aa)
fbpUnannotated protein; Belongs to the FBPase class 1 family. (322 aa)
GcvTUnannotated protein. (370 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (121 aa)
gcvPAUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa)
CD943_11890Unannotated protein. (525 aa)
CD943_04060Unannotated protein; Belongs to the PEP-utilizing enzyme family. (896 aa)
CD943_03675Unannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (386 aa)
CD943_03645Unannotated protein; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (398 aa)
gapUnannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa)
tktUnannotated protein; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (664 aa)
AceAUnannotated protein. (425 aa)
CD943_03185Unannotated protein; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (629 aa)
CD943_02990Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (396 aa)
glcBUnannotated protein; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
rpiAUnannotated protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (227 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (307 aa)
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (315 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (249 aa)
gltAUnannotated protein; Belongs to the citrate synthase family. (433 aa)
cysEUnannotated protein. (273 aa)
CD943_11025Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
acoAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (342 aa)
CD943_16275Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (449 aa)
CD943_16285Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (418 aa)
lpdAUnannotated protein. (468 aa)
CD943_16300Unannotated protein. (334 aa)
GCA_000988015_01188Unannotated protein. (428 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (316 aa)
CD943_01530Unannotated protein. (502 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (450 aa)
CD943_10115Unannotated protein; Belongs to the catalase family. (495 aa)
CD943_10490Unannotated protein. (400 aa)
fabG_7Unannotated protein. (241 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa)
mceUnannotated protein. (140 aa)
mutBUnannotated protein. (719 aa)
CD943_02580Unannotated protein. (658 aa)
CD943_02585Unannotated protein. (511 aa)
mmsAUnannotated protein. (500 aa)
CD943_05165Unannotated protein. (153 aa)
acsUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa)
CD943_05565Unannotated protein; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (406 aa)
fghAUnannotated protein; Serine hydrolase involved in the detoxification of formaldehyde. (277 aa)
CD943_05620Unannotated protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (368 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (534 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (484 aa)
eddUnannotated protein; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (629 aa)
glkUnannotated protein; Belongs to the bacterial glucokinase family. (322 aa)
CD943_06225Unannotated protein. (223 aa)
glyA-2Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
lpdA-2Unannotated protein. (465 aa)
talUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
lpdA-3Unannotated protein. (470 aa)
fadA_1Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (401 aa)
CD943_07280Unannotated protein. (730 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (299 aa)
gpmAUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (237 aa)
OdhBUnannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (501 aa)
CD943_07885Unannotated protein. (1006 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (396 aa)
CD943_07935Unannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (227 aa)
pgiUnannotated protein; Belongs to the GPI family. (534 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sdhCUnannotated protein. (153 aa)
CD943_08180Unannotated protein. (131 aa)
CD943_08185Unannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (594 aa)
CD943_08190Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (265 aa)
CD943_08260Unannotated protein. (768 aa)
acnAUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
CD943_09105Unannotated protein. (324 aa)
GCA_000988015_02772Unannotated protein. (323 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
ppcUnannotated protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (901 aa)
fadB2Unannotated protein. (292 aa)
Your Current Organism:
Brevundimonas diminuta
NCBI taxonomy Id: 293
Other names: AJ 2067, ATCC 11568, B. diminuta, BCRC 11894, Bacterium parvulum, CCEB 513, CCRC 11894, CCRC:11894, CECT 317, CIP 63.27, DSM 7234, IAM 12691, IFO 12697, IMET 10409, JCM 2788, LMG 2088, LMG 2089, LMG:2088, LMG:2089, NBRC 12697, NCAIM B.01118, NCCB 76050, NCIB 9393, NCIMB 9393, NCTC 8545, Pseudomonas diminuta
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