STRINGSTRING
CCDG5_0011 CCDG5_0011 CCDG5_0105 CCDG5_0105 CCDG5_0225 CCDG5_0225 CCDG5_0233 CCDG5_0233 CCDG5_0315 CCDG5_0315 CCDG5_0316 CCDG5_0316 CCDG5_0433 CCDG5_0433 pyrB pyrB CCDG5_0763 CCDG5_0763 CCDG5_0764 CCDG5_0764 CCDG5_0937 CCDG5_0937 punA punA pyrR pyrR pyrC pyrC pyrF pyrF carA carA carB carB CCDG5_1008 CCDG5_1008 pyrD pyrD thyX thyX cmk cmk upp upp udp udp pyrG pyrG CCDG5_1639 CCDG5_1639 pyrH pyrH pyrE pyrE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCDG5_0011Deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (149 aa)
CCDG5_0105Metal dependent phosphohydrolase; High confidence in function and specificity. (195 aa)
CCDG5_0225Phosphoribulokinase / uridine kinase family protein; High confidence in function and specificity. (320 aa)
CCDG5_0233Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (739 aa)
CCDG5_0315Hypothetical protein; High confidence in function and specificity. (166 aa)
CCDG5_0316Hypothetical protein; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (137 aa)
CCDG5_0433Hypothetical protein; Family membership; Belongs to the Nudix hydrolase family. (137 aa)
pyrBAspartate carbamoyltransferase; High confidence in function and specificity; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (356 aa)
CCDG5_0763Hypothetical protein; Family membership. (317 aa)
CCDG5_0764Uridine phosphorylase; High confidence in function and specificity. (249 aa)
CCDG5_0937Anaerobic ribonucleoside-triphosphate reductase; High confidence in function and specificity. (783 aa)
punAPurine nucleoside phosphorylase 1; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (282 aa)
pyrRUracil phosphoribosyltransferase; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant; Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. (186 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (421 aa)
pyrFOrotidine 5'-phosphate decarboxylase; High confidence in function and specificity; Belongs to the OMP decarboxylase family. Type 2 subfamily. (305 aa)
carACarbamoyl-phosphate synthase small chain; High confidence in function and specificity; Belongs to the CarA family. (363 aa)
carBCarbamoyl-phosphate synthase large chain; High confidence in function and specificity; Belongs to the CarB family. (1063 aa)
CCDG5_1008Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain; High confidence in function and specificity. (254 aa)
pyrDDihydroorotate dehydrogenase B (NAD(+)), catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (310 aa)
thyXHypothetical protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (262 aa)
cmkCytidylate kinase; High confidence in function and specificity. (227 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa)
udpUridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (257 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (534 aa)
CCDG5_1639Nucleoside diphosphate kinase; High confidence in function and specificity. (151 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (224 aa)
Your Current Organism:
Clostridium cellulosi
NCBI taxonomy Id: 29343
Other names: [. cellulosi, [Clostridium] cellulosi
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.