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Amet_0697 Amet_0697 Amet_0783 Amet_0783 Amet_1198 Amet_1198 Amet_1212 Amet_1212 Amet_1547 Amet_1547 Amet_1616 Amet_1616 Amet_1648 Amet_1648 Amet_1661 Amet_1661 Amet_1676 Amet_1676 Amet_1678 Amet_1678 Amet_1722 Amet_1722 Amet_2027 Amet_2027 Amet_2052 Amet_2052 Amet_2085 Amet_2085 Amet_2086 Amet_2086 Amet_2092 Amet_2092 Amet_2093 Amet_2093 Amet_2097 Amet_2097 Amet_2205 Amet_2205 glyA glyA Amet_2370 Amet_2370 Amet_2371 Amet_2371 Amet_2373 Amet_2373 iscS iscS dxs dxs Amet_2618 Amet_2618 Amet_2633 Amet_2633 Amet_2653 Amet_2653 Amet_2776 Amet_2776 Amet_2804 Amet_2804 Amet_2945 Amet_2945 Amet_2955 Amet_2955 Amet_2999 Amet_2999 Amet_3116 Amet_3116 Amet_3155 Amet_3155 Amet_3167 Amet_3167 Amet_3193 Amet_3193 Amet_3280 Amet_3280 Amet_3333 Amet_3333 Amet_3373 Amet_3373 Amet_3374 Amet_3374 Amet_3376 Amet_3376 argD argD Amet_3400 Amet_3400 Amet_3404 Amet_3404 glmE glmE glmS glmS Amet_3418 Amet_3418 Amet_3484 Amet_3484 Amet_3485 Amet_3485 Amet_3487 Amet_3487 Amet_3490 Amet_3490 Amet_3614 Amet_3614 Amet_3634 Amet_3634 Amet_3706 Amet_3706 Amet_3707 Amet_3707 Amet_4073 Amet_4073 Amet_4095 Amet_4095 Amet_4145 Amet_4145 Amet_4304 Amet_4304 Amet_4317 Amet_4317 Amet_4324 Amet_4324 lysA lysA Amet_4428 Amet_4428 hisC-2 hisC-2 Amet_4541 Amet_4541 Amet_4542 Amet_4542 Amet_4548 Amet_4548 Amet_4727 Amet_4727 Amet_4549 Amet_4549 Amet_4562 Amet_4562 Amet_4586 Amet_4586 Amet_4715 Amet_4715 Amet_4657 Amet_4657 Amet_0031 Amet_0031 Amet_0057 Amet_0057 hemL hemL eutC eutC Amet_0257 Amet_0257 Amet_0504 Amet_0504 Amet_0510 Amet_0510 Amet_0540 Amet_0540 Amet_0567 Amet_0567 hisC hisC Amet_0601 Amet_0601
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
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co-expression
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Amet_0697TIGRFAM: 4-aminobutyrate aminotransferase; PFAM: aminotransferase class-III; KEGG: cac:CAC1427 4-aminobutyrate aminotransferase (PLP-dependent); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (441 aa)
Amet_0783PFAM: aminotransferase, class IV; KEGG: cac:CAC2226 enzyme of IlvE/PabC family (branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase). (288 aa)
Amet_1198TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: bha:BH2373 2-oxoglutarate ferredoxin oxidoreductase, beta subunit. (288 aa)
Amet_1212TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, beta subunit; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: tte:TTE0960 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (285 aa)
Amet_1547Putative transcriptional regulator, GntR family; PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: btl:BALH_2995 transcriptional regulator, GntR family. (465 aa)
Amet_1616PFAM: aminotransferase, class I and II; KEGG: mja:MJ1391 aspartate aminotransferase. (410 aa)
Amet_1648PFAM: Orn/DAP/Arg decarboxylase 2; KEGG: nfa:nfa25650 putative decarboxylase. (482 aa)
Amet_1661Indolepyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (595 aa)
Amet_1676PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: cth:Cthe_3120 pyruvate flavodoxin/ferredoxin oxidoreductase-like protein. (1176 aa)
Amet_1678Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (786 aa)
Amet_1722PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: cth:Cthe_3186 radical SAM. (587 aa)
Amet_2027PFAM: dihydropteroate synthase, DHPS; KEGG: mta:Moth_1197 dihydropteroate synthase, DhpS. (261 aa)
Amet_2052Hypothetical protein. (378 aa)
Amet_2085PFAM: dihydropteroate synthase, DHPS; KEGG: dsy:DSY2719 hypothetical protein. (274 aa)
Amet_2086PFAM: Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein; KEGG: dsy:DSY0588 hypothetical protein. (216 aa)
Amet_2092PFAM: dihydropteroate synthase, DHPS; KEGG: dsy:DSY2719 hypothetical protein. (269 aa)
Amet_2093PFAM: Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein; KEGG: dsy:DSY0588 hypothetical protein. (216 aa)
Amet_2097PFAM: Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein; KEGG: dsy:DSY2717 hypothetical protein. (226 aa)
Amet_2205PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; KEGG: cpf:CPF_1667 aminotransferase, class V. (385 aa)
glyAGlycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (410 aa)
Amet_2370KEGG: tte:TTE1237 hypothetical protein. (121 aa)
Amet_2371PFAM: cobalamin B12-binding domain protein; D-Lysine 5,6-aminomutase alpha subunit; KEGG: tte:TTE1238 methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding). (736 aa)
Amet_2373PFAM: alanine racemase domain protein; KEGG: ppr:PBPRB0280 hypothetical protein. (364 aa)
iscSAminotransferase, class V; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (395 aa)
dxsDeoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (636 aa)
Amet_2618PFAM: aminotransferase, class I and II; KEGG: ftn:FTN_0410 aspartate/tyrosine/aromatic aminotransferase. (399 aa)
Amet_2633PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: tte:TTE1341 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit. (273 aa)
Amet_2653PFAM: aminotransferase, class I and II; KEGG: cth:Cthe_0755 aminotransferase, class I and II. (397 aa)
Amet_2776TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic region; KEGG: tte:TTE1497 thiamine pyrophosphokinase. (211 aa)
Amet_2804Alanine racemase domain protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family. (231 aa)
Amet_2945Glycogen/starch/alpha-glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (827 aa)
Amet_2955Hypothetical protein; KEGG: tte:TTE0924 methionine synthase I, cobalamin-binding domain. (636 aa)
Amet_2999Putative transcriptional regulator, GntR family; PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: bsu:BG12133 similar to transcriptional regulator (GntR family) / aminotransferase (MocR-like). (462 aa)
Amet_3116PFAM: glycine hydroxymethyltransferase; aminotransferase, class I and II; KEGG: pho:PH1654 serine hydroxymethyltransferase. (368 aa)
Amet_3155Putative transcriptional regulator, GntR family; PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: cth:Cthe_2689 transcriptional regulator, GntR family. (494 aa)
Amet_3167PFAM: MOSC domain containing protein; KEGG: ppd:Ppro_0303 MOSC domain containing protein. (147 aa)
Amet_3193PFAM: aminotransferase class-III; KEGG: bcl:ABC2432 acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (392 aa)
Amet_3280PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: cth:Cthe_2566 radical SAM. (440 aa)
Amet_3333Indolepyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (604 aa)
Amet_3373PFAM: dihydropteroate synthase, DHPS; homocysteine S-methyltransferase; Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein; KEGG: ctc:CTC01806 5-methyltetrahydrofolate--homocysteine methyltransferase. (789 aa)
Amet_3374PFAM: Vitamin B12 dependent methionine synthase, activation region; KEGG: ctc:CTC01807 putative 5-methyltetrahydrofolate--homocysteine methyltransferase. (226 aa)
Amet_3376TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; DegT/DnrJ/EryC1/StrS aminotransferase; aminotransferase, class I and II; KEGG: lmf:LMOf2365_0624 O-acetylhomoserine (thiol)-lyase. (425 aa)
argDTIGRFAM: acetylornithine and succinylornithine aminotransferase; PFAM: aminotransferase class-III; KEGG: mta:Moth_2287 acetylornithine and succinylornithine aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa)
Amet_3400TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein, central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: cth:Cthe_2714 acetolactate synthase, large subunit, biosynthetic type. (554 aa)
Amet_3404TIGRFAM: threonine dehydratase; PFAM: Pyridoxal-5'-phosphate-dependent protein, beta subunit; amino acid-binding ACT domain protein; KEGG: fnu:FN1411 threonine dehydratase. (414 aa)
glmEMethylaspartate mutase, E subunit; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (484 aa)
glmSMethylaspartate mutase, S subunit; Catalyzes the carbon skeleton rearrangement of L-glutamate to L-threo-3-methylaspartate ((2S,3S)-3-methylaspartate). (151 aa)
Amet_3418TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; thiamine pyrophosphate protein, central region; thiamine pyrophosphate protein TPP binding domain protein; KEGG: eba:ebA4751 putative acetolactate synthase large subunit. (571 aa)
Amet_3484PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: gme:Gmet_1690 radical SAM. (438 aa)
Amet_3485PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dsy:DSY4423 hypothetical protein. (449 aa)
Amet_3487PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dsy:DSY4423 hypothetical protein. (441 aa)
Amet_3490PFAM: aminotransferase, class I and II; KEGG: mta:Moth_1955 aminotransferase, class I and II. (390 aa)
Amet_3614TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II; KEGG: fnu:FN0973 histidinol-phosphate aminotransferase. (359 aa)
Amet_3634Pyridoxal phosphate-dependent acyltransferase, putative; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (395 aa)
Amet_3706Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cac:CAC0391 cystathionine beta-lyase. (380 aa)
Amet_3707Cystathionine gamma-synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cth:Cthe_2799 cystathionine gamma-synthase. (385 aa)
Amet_4073TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase-like; KEGG: pgi:PG0329 formiminotransferase-cyclodeaminase-related protein. (298 aa)
Amet_4095KEGG: chy:CHY_0804 MOSC domain protein. (136 aa)
Amet_4145Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (391 aa)
Amet_4304PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: cth:Cthe_0865 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). (248 aa)
Amet_4317PFAM: aminotransferase class-III; KEGG: tte:TTE2339 PLP-dependent aminotransferases; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (473 aa)
Amet_4324KEGG: ctc:CTC01689 hypothetical protein. (187 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (433 aa)
Amet_4428PFAM: thiamine pyrophosphate protein domain protein TPP-binding; KEGG: cth:Cthe_0865 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin). (250 aa)
hisC-2TIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; KEGG: mta:Moth_0515 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (358 aa)
Amet_4541PFAM: cobalamin B12-binding domain protein; KEGG: tte:TTE2388 methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding). (132 aa)
Amet_4542TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase; KEGG: tte:TTE2389 Methylmalonyl-CoA mutase, N-terminal domain/subunit. (559 aa)
Amet_4548PFAM: cobalamin B12-binding domain protein; KEGG: tte:TTE0727 D-lysine 5,6-aminomutase beta subunit. (251 aa)
Amet_4727Putative transcriptional regulator, GntR family; PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II; KEGG: btl:BALH_2995 transcriptional regulator, GntR family. (467 aa)
Amet_4549PFAM: D-Lysine 5,6-aminomutase alpha subunit; KEGG: tte:TTE0726 D-lysine 5,6-aminomutase alpha subunit. (518 aa)
Amet_4562PFAM: aminotransferase, class I and II; KEGG: efa:EF0891 aspartate aminotransferase, putative. (391 aa)
Amet_4586TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase-like; KEGG: chy:CHY_0695 glutamate formiminotransferase. (302 aa)
Amet_4715KEGG: tte:TTE2425 hypothetical protein. (136 aa)
Amet_4657PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: tte:TTE0445 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit. (1171 aa)
Amet_0031Putative transcriptional regulator, GntR family; PFAM: aminotransferase, class I and II; KEGG: mmp:MMP0096 aminotransferase (subgroup I). (397 aa)
Amet_0057Cysteine synthase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent protein; KEGG: cac:CAC0102 O-acetylhomoserine (thiol)-lyase. (411 aa)
hemLTIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; KEGG: chy:CHY_1212 glutamate-1-semialdehyde-2,1-aminomutase. (440 aa)
eutCPFAM: Ethanolamine ammonia-lyase light chain; KEGG: ctc:CTC02175 ethanolamine ammonia-lyase light chain; Belongs to the EutC family. (299 aa)
Amet_0257PFAM: microcompartments protein; KEGG: fnu:FN0081 ethanolamine utilization protein eutL. (217 aa)
Amet_0504PFAM: aminotransferase, class I and II; KEGG: art:Arth_1423 aminotransferase, class I and II. (386 aa)
Amet_0510PFAM: aminotransferase class-III; KEGG: pfu:PF1232 4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
Amet_0540PFAM: Pyridoxal-5'-phosphate-dependent protein, beta subunit; KEGG: tac:Ta0113 probable threonine dehydratase, biodegradative. (317 aa)
Amet_0567Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (353 aa)
hisCTIGRFAM: histidinol-phosphate aminotransferase; PFAM: aminotransferase, class I and II; Allinase-like; KEGG: cno:NT01CX_1063 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (363 aa)
Amet_0601PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; KEGG: dsy:DSY4423 hypothetical protein. (453 aa)
Your Current Organism:
Alkaliphilus metalliredigens
NCBI taxonomy Id: 293826
Other names: A. metalliredigens QYMF, Alkaliphilus metalliredigens QYMF, Alkaliphilus metalliredigens str. QYMF, Alkaliphilus metalliredigens strain QYMF
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