STRINGSTRING
yafQ yafQ vapC vapC CEL27044.1 CEL27044.1 nucH nucH higB higB orn orn rnr rnr recC recC recB_1 recB_1 recD_1 recD_1 CEL27504.1 CEL27504.1 yjjV yjjV rng rng yihG_1 yihG_1 CEL27694.1 CEL27694.1 rnc rnc recJ recJ rnhB rnhB dnaE dnaE CEL27853.1 CEL27853.1 CEL27888.1 CEL27888.1 CEL27897.1 CEL27897.1 CEL27998.1 CEL27998.1 rnd rnd CEL28052.1 CEL28052.1 dnaE2_1 dnaE2_1 CEL28250.1 CEL28250.1 smrA smrA xthA_1 xthA_1 uvrB uvrB CEL28693.1 CEL28693.1 dns dns CEL28821.1 CEL28821.1 hcpA_1 hcpA_1 rnhA rnhA dnaQ dnaQ CEL29102.1 CEL29102.1 CEL29167.1 CEL29167.1 helD helD CEL29335.1 CEL29335.1 CEL29402.1 CEL29402.1 traC_2 traC_2 CEL29437.1 CEL29437.1 uvrC uvrC pilT_1 pilT_1 relE relE uvrA_1 uvrA_1 dnaE2_2 dnaE2_2 sbcD sbcD sbcC sbcC CEL29865.1 CEL29865.1 CEL30120.1 CEL30120.1 xthA_2 xthA_2 CEL30189.1 CEL30189.1 CEL32314.1 CEL32314.1 rph rph exoA exoA rep rep CEL32159.1 CEL32159.1 CEL32158.1 CEL32158.1 CEL32136.1 CEL32136.1 yqgF yqgF yihG_2 yihG_2 polC_3 polC_3 uvrA_2 uvrA_2 recD2_2 recD2_2 CEL31760.1 CEL31760.1 CEL31748.1 CEL31748.1 xseB xseB mrr mrr hsdR hsdR ybeY ybeY CEL31633.1 CEL31633.1 CEL31600.1 CEL31600.1 polC_2 polC_2 CEL31529.1 CEL31529.1 CEL31419.1 CEL31419.1 CEL31368.1 CEL31368.1 CEL31304.1 CEL31304.1 xseA xseA hcpA_2 hcpA_2 rnt_2 rnt_2 nth nth sbcB sbcB ruvC ruvC CEL30931.1 CEL30931.1 CEL30883.1 CEL30883.1 rne rne holB holB ycfH ycfH CEL30719.1 CEL30719.1 CEL30716.1 CEL30716.1 tatD tatD uvrD_1 uvrD_1 polC_1 polC_1 CEL30363.1 CEL30363.1 polB polB CEL30256.1 CEL30256.1 CEL30231.1 CEL30231.1 rnpA rnpA dnaN dnaN polA polA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yafQmRNA interferase YafQ. (104 aa)
vapCtRNA(fMet)-specific endonuclease VapC. (135 aa)
CEL27044.1Hypothetical protein. (352 aa)
nucHThermonuclease precursor. (270 aa)
higBmRNA interferase HigB. (96 aa)
ornOligoribonuclease; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (180 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (876 aa)
recCRecBCD enzyme subunit RecC; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] (1150 aa)
recB_1RecBCD enzyme subunit RecB; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] (1229 aa)
recD_1RecBCD enzyme subunit RecD; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holo [...] (702 aa)
CEL27504.1Hypothetical protein. (728 aa)
yjjVPutative deoxyribonuclease YjjV. (258 aa)
rngRibonuclease G. (485 aa)
yihG_1Putative acyltransferase YihG. (301 aa)
CEL27694.1GIY-YIG nuclease superfamily protein. (100 aa)
rncRibonuclease 3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (208 aa)
recJSingle-stranded-DNA-specific exonuclease RecJ. (569 aa)
rnhBRibonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (208 aa)
dnaEDNA polymerase III subunit alpha. (1173 aa)
CEL27853.1Hypothetical protein. (155 aa)
CEL27888.1Hypothetical protein. (218 aa)
CEL27897.1Hypothetical protein. (344 aa)
CEL27998.1YcfA-like protein. (59 aa)
rndRibonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family. (377 aa)
CEL28052.1Hypothetical protein. (123 aa)
dnaE2_1Error-prone DNA polymerase. (287 aa)
CEL28250.1Hypothetical protein. (191 aa)
smrAPutative DNA endonuclease SmrA. (185 aa)
xthA_1Exodeoxyribonuclease III. (264 aa)
uvrBUvrABC system protein B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and [...] (671 aa)
CEL28693.1HNH endonuclease. (127 aa)
dnsExtracellular deoxyribonuclease precursor. (229 aa)
CEL28821.1Hypothetical protein. (111 aa)
hcpA_1Major exported protein. (166 aa)
rnhARibonuclease HI; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (153 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (258 aa)
CEL29102.1Hypothetical protein. (260 aa)
CEL29167.1Hypothetical protein. (142 aa)
helDHelicase IV. (917 aa)
CEL29335.1Hypothetical protein. (154 aa)
CEL29402.1VRR-NUC domain protein. (552 aa)
traC_2DNA primase TraC. (225 aa)
CEL29437.1Hypothetical protein. (366 aa)
uvrCUvrABC system protein C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (612 aa)
pilT_1Twitching mobility protein. (369 aa)
relEmRNA interferase RelE. (93 aa)
uvrA_1UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (877 aa)
dnaE2_2Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1025 aa)
sbcDNuclease SbcCD subunit D; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family. (414 aa)
sbcCNuclease SbcCD subunit C. (1213 aa)
CEL29865.1Putative DNA ligase-like protein/MT0965. (866 aa)
CEL30120.1Ribonuclease VapC22. (125 aa)
xthA_2Exodeoxyribonuclease III. (270 aa)
CEL30189.1Hypothetical protein. (82 aa)
CEL32314.1Hypothetical protein. (287 aa)
rphRibonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (240 aa)
exoAExodeoxyribonuclease. (259 aa)
repATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (669 aa)
CEL32159.1SdiA-regulated. (307 aa)
CEL32158.1SdiA-regulated. (305 aa)
CEL32136.1Calcineurin-like phosphoesterase superfamily domain protein. (244 aa)
yqgFPutative Holliday junction resolvase; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (145 aa)
yihG_2Putative acyltransferase YihG. (295 aa)
polC_3DNA polymerase III PolC-type. (235 aa)
uvrA_2UvrABC system protein A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (944 aa)
recD2_2ATP-dependent RecD-like DNA helicase. (759 aa)
CEL31760.1Hypothetical protein. (265 aa)
CEL31748.1Hypothetical protein. (193 aa)
xseBExodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
mrrMrr restriction system protein. (306 aa)
hsdRType-1 restriction enzyme R protein. (1038 aa)
ybeYEndoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (164 aa)
CEL31633.1Integrase core domain protein. (504 aa)
CEL31600.1NYN domain protein. (159 aa)
polC_2DNA polymerase III PolC-type. (201 aa)
CEL31529.1Hypothetical protein. (184 aa)
CEL31419.1Hypothetical protein. (320 aa)
CEL31368.1Hypothetical protein. (120 aa)
CEL31304.1Bacteriophage replication gene A protein (GPA). (527 aa)
xseAExodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (459 aa)
hcpA_2Major exported protein. (171 aa)
rnt_2Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. (225 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)
sbcBExodeoxyribonuclease I. (476 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (175 aa)
CEL30931.1Hypothetical protein. (78 aa)
CEL30883.1HNH endonuclease. (237 aa)
rneRibonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1083 aa)
holBDNA polymerase III subunit delta'. (327 aa)
ycfHPutative deoxyribonuclease YcfH. (261 aa)
CEL30719.1Putative hydrolase. (217 aa)
CEL30716.1PAAR motif protein. (164 aa)
tatDTat-linked quality control protein TatD. (268 aa)
uvrD_1DNA helicase II. (584 aa)
polC_1DNA polymerase III PolC-type. (180 aa)
CEL30363.1Ribonuclease T2 family protein. (221 aa)
polBDNA polymerase II. (787 aa)
CEL30256.1YqaJ-like viral recombinase domain protein. (205 aa)
CEL30231.1Bacteriophage Lambda NinG protein. (199 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (145 aa)
dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (934 aa)
Your Current Organism:
Pseudomonas fluorescens
NCBI taxonomy Id: 294
Other names: ATCC 13525, Bacillus fluorescens, Bacillus fluorescens liquefaciens, Bacterium fluorescen, CCEB 546, CFBP 2102, CIP 69.13, DSM 50090, IAM 12022, IFO 14160, JCM 5963, Liquidomonas fluorescens, NBRC 14160, NCCB 76040, NCIB 9046, NCIB:9046, NCIMB 9046, NCTC 10038, NRRL B-14678, P. fluorescens, Pseudomonas sp. AU2390, Pseudomonas sp. BZ64, Pseudomonas sp. FY32, Pseudomonas sp. HSA2/2016, Pseudomonas sp. HSA3/2016, Pseudomonas sp. ISSDS-433, Pseudomonas sp. JCM 17186, Pseudomonas sp. JCM 2779, Pseudomonas sp. KH-20150KS3, Pseudomonas sp. LBUM223, Pseudomonas sp. LBUM636, Pseudomonas sp. SM2/2016, RH 818, VKM B-894, bacterium P1-1, strain M. Rhodes 28/5
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