STRINGSTRING
dnaN dnaN mutL mutL CEL27504.1 CEL27504.1 sodB_1 sodB_1 holC holC recJ recJ dnaE dnaE mutS mutS CEL27896.1 CEL27896.1 CEL27897.1 CEL27897.1 CEL28372.1 CEL28372.1 ligA ligA dnaX dnaX dnaQ dnaQ prsA2 prsA2 lexA_1 lexA_1 CEL29335.1 CEL29335.1 yjcD yjcD traC_2 traC_2 ppiC_1 ppiC_1 ppiC_2 ppiC_2 dnaE2_2 dnaE2_2 lexA_2 lexA_2 surA_1 surA_1 CEL30151.1 CEL30151.1 ppiD ppiD CEL30245.1 CEL30245.1 lexA_3 lexA_3 uvrD_1 uvrD_1 uvrD_2 uvrD_2 holB holB CEL30931.1 CEL30931.1 sbcB sbcB sodB_2 sodB_2 rnt_2 rnt_2 lexA_4 lexA_4 xseA xseA polC_2 polC_2 yceD_1 yceD_1 yceD_2 yceD_2 CEL31616.1 CEL31616.1 yceD_3 yceD_3 yceD_4 yceD_4 yceC yceC holA holA xseB xseB ssb ssb surA_2 surA_2 polC_3 polC_3 ligB ligB recB_2 recB_2 pcrA pcrA rep rep uvrD_3 uvrD_3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
dnaNDNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (636 aa)
CEL27504.1Hypothetical protein. (728 aa)
sodB_1Superoxide dismutase [Mn/Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (218 aa)
holCDNA polymerase III subunit chi. (142 aa)
recJSingle-stranded-DNA-specific exonuclease RecJ. (569 aa)
dnaEDNA polymerase III subunit alpha. (1173 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (859 aa)
CEL27896.1Putative DNA ligase-like protein/MT0965. (562 aa)
CEL27897.1Hypothetical protein. (344 aa)
CEL28372.1Single-stranded DNA-binding protein. (151 aa)
ligADNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (785 aa)
dnaXDNA polymerase III subunit tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (689 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (258 aa)
prsA2Foldase protein PrsA 2 precursor. (315 aa)
lexA_1LexA repressor. (143 aa)
CEL29335.1Hypothetical protein. (154 aa)
yjcDPutative ATP-dependent DNA helicase YjcD. (824 aa)
traC_2DNA primase TraC. (225 aa)
ppiC_1Peptidyl-prolyl cis-trans isomerase C. (93 aa)
ppiC_2Peptidyl-prolyl cis-trans isomerase C. (91 aa)
dnaE2_2Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1025 aa)
lexA_2LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (205 aa)
surA_1Chaperone SurA. (253 aa)
CEL30151.1Putative HTH-type transcriptional regulator. (219 aa)
ppiDPeptidyl-prolyl cis-trans isomerase D. (623 aa)
CEL30245.1Putative HTH-type transcriptional regulator. (211 aa)
lexA_3LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa)
uvrD_1DNA helicase II. (584 aa)
uvrD_2DNA helicase II. (560 aa)
holBDNA polymerase III subunit delta'. (327 aa)
CEL30931.1Hypothetical protein. (78 aa)
sbcBExodeoxyribonuclease I. (476 aa)
sodB_2Superoxide dismutase [Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (198 aa)
rnt_2Ribonuclease T; Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis. (225 aa)
lexA_4LexA repressor. (182 aa)
xseAExodeoxyribonuclease 7 large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (459 aa)
polC_2DNA polymerase III PolC-type. (201 aa)
yceD_1General stress protein 16U. (429 aa)
yceD_2General stress protein 16U. (418 aa)
CEL31616.1Hypothetical protein. (397 aa)
yceD_3General stress protein 16U. (192 aa)
yceD_4General stress protein 16U. (191 aa)
yceCStress response protein SCP2. (195 aa)
holADNA polymerase III subunit delta. (345 aa)
xseBExodeoxyribonuclease 7 small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (80 aa)
ssbSingle-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (174 aa)
surA_2Chaperone SurA precursor; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (440 aa)
polC_3DNA polymerase III PolC-type. (235 aa)
ligBDNA ligase B. (555 aa)
recB_2RecBCD enzyme subunit RecB. (362 aa)
pcrAATP-dependent DNA helicase PcrA. (1101 aa)
repATP-dependent DNA helicase Rep; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. (669 aa)
uvrD_3DNA helicase II. (727 aa)
Your Current Organism:
Pseudomonas fluorescens
NCBI taxonomy Id: 294
Other names: ATCC 13525, Bacillus fluorescens, Bacillus fluorescens liquefaciens, Bacterium fluorescen, CCEB 546, CFBP 2102, CIP 69.13, DSM 50090, IAM 12022, IFO 14160, JCM 5963, Liquidomonas fluorescens, NBRC 14160, NCCB 76040, NCIB 9046, NCIB:9046, NCIMB 9046, NCTC 10038, NRRL B-14678, P. fluorescens, Pseudomonas sp. AU2390, Pseudomonas sp. BZ64, Pseudomonas sp. FY32, Pseudomonas sp. HSA2/2016, Pseudomonas sp. HSA3/2016, Pseudomonas sp. ISSDS-433, Pseudomonas sp. JCM 17186, Pseudomonas sp. JCM 2779, Pseudomonas sp. KH-20150KS3, Pseudomonas sp. LBUM223, Pseudomonas sp. LBUM636, Pseudomonas sp. SM2/2016, RH 818, VKM B-894, bacterium P1-1, strain M. Rhodes 28/5
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