STRINGSTRING
thiC thiC YLM1_0051 YLM1_0051 YLM1_0081 YLM1_0081 mptE mptE thiC-2 thiC-2 thiI thiI YLM1_0194 YLM1_0194 YLM1_0214 YLM1_0214 YLM1_0215 YLM1_0215 YLM1_0216 YLM1_0216 YLM1_0217 YLM1_0217 YLM1_0295 YLM1_0295 YLM1_0296 YLM1_0296 YLM1_0511 YLM1_0511 metXA metXA YLM1_0717 YLM1_0717 YLM1_0877 YLM1_0877 YLM1_0878 YLM1_0878 YLM1_0881 YLM1_0881 YLM1_0882 YLM1_0882 YLM1_0932 YLM1_0932 YLM1_0933 YLM1_0933 YLM1_0934 YLM1_0934 YLM1_0935 YLM1_0935 YLM1_1055 YLM1_1055 YLM1_1059 YLM1_1059 YLM1_1060 YLM1_1060 YLM1_1082 YLM1_1082 YLM1_1113 YLM1_1113 asd asd YLM1_1228 YLM1_1228 thiE thiE thiM thiM YLM1_1285 YLM1_1285 YLM1_1286 YLM1_1286 YLM1_1287 YLM1_1287 YLM1_1399 YLM1_1399 cofG cofG YLM1_1417 YLM1_1417 YLM1_1470 YLM1_1470 bioW bioW YLM1_1482 YLM1_1482 YLM1_1488 YLM1_1488 mat mat dadD dadD thiL thiL YLM1_1703 YLM1_1703 YLM1_1723 YLM1_1723 bioB bioB bioD bioD YLM1_1796 YLM1_1796
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (432 aa)
YLM1_0051S-adenosyl-L-homocysteine hydrolase AhcY; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. (416 aa)
YLM1_0081Acetolactate synthase large subunit IlvB; Belongs to the TPP enzyme family. (599 aa)
mptEHypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (243 aa)
thiC-2Thiamine biosynthesis protein ThiC2; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (424 aa)
thiIThiamine biosynthesis ATP pyrophosphatase ThiI; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (382 aa)
YLM1_0194BioB family protein HcgA. (334 aa)
YLM1_0214Pyruvate ferredoxin oxidoreductase gamma subunit PorC. (173 aa)
YLM1_0215Pyruvate ferredoxin oxidoreductase delta subunit PorD. (80 aa)
YLM1_0216Pyruvate ferredoxin oxidoreductase alpha subunit PorA. (382 aa)
YLM1_0217Pyruvate ferredoxin oxidoreductase beta subunit PorB. (288 aa)
YLM1_0295Indolepyruvate ferredoxin oxidoreductase alpha subunit IorA. (663 aa)
YLM1_0296Indolepyruvate ferredoxin oxidoreductase beta subunit IorB. (212 aa)
YLM1_0511Phosphomethylpyrimidine kinase ThiD. (276 aa)
metXAHomoserine O-acetyltransferase MetX; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (490 aa)
YLM1_0717O-acetylhomoserine/O-acetylserine sulfhydrylase MetZ/CysK. (427 aa)
YLM1_0877Methanogeneis marker protein 16. (416 aa)
YLM1_0878Phosphosulfolactate synthase ComA. (257 aa)
YLM1_0881Sulfopyruvate decarboxylase alpha subunit ComD. (163 aa)
YLM1_0882Sulfopyruvate decarboxylase beta subunit ComE. (185 aa)
YLM1_0932Ketoisovalerate ferredoxin oxidoreductase beta subunit VorB. (498 aa)
YLM1_0933Ketoisovalerate ferredoxin oxidoreductase alpha subunit VorA. (388 aa)
YLM1_0934Ketoisovalerate ferredoxin oxidoreductase gamma subunit VorC. (84 aa)
YLM1_0935acetyl-CoA synthetase AcsA. (556 aa)
YLM1_1055O-acetylhomoserine/O-acetylserine sulfhydrylase MetZ/CysK. (438 aa)
YLM1_1059Serine O-acetyltransferase CysE. (233 aa)
YLM1_1060Cysteine synthase CysKM. (318 aa)
YLM1_1082Carbonic anhydrase Cab. (175 aa)
YLM1_1113Methionine synthase MetE. (318 aa)
asdAspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (349 aa)
YLM1_1228Translation initiation factor aIF-2B alpha subunit; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily. (319 aa)
thiEThiamine monophosphate synthase ThiE; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (209 aa)
thiMHydroxyethylthiazole kinase ThiM; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (303 aa)
YLM1_12852-oxoglutarate ferredoxin oxidoreductase subunit gamma KorC. (181 aa)
YLM1_12862-oxoglutarate ferredoxin oxidoreductase subunit beta KorB. (287 aa)
YLM1_12872-oxoglutarate ferredoxin oxidoreductase subunit alpha KorA. (377 aa)
YLM1_13992-phosphosulfolactate phosphatase ComB. (250 aa)
cofGFO synthase subunit 1 CofG; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil. (375 aa)
YLM1_1417L-sulfolactate dehydrogenase ComC. (342 aa)
YLM1_1470Radical SAM domain-containing protein. (331 aa)
bioW6-carboxyhexanoate--CoA ligase BioW; Catalyzes the transformation of pimelate into pimeloyl-CoA with concomitant hydrolysis of ATP to AMP. (253 aa)
YLM1_14828-amino-7-oxononanoate synthase BioF; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (411 aa)
YLM1_1488Hydrogenase expression/formation protein HypE. (457 aa)
matS-adenosylmethionine synthetase MetK; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (401 aa)
dadDAmidohydrolase; Catalyzes the deamination of three SAM-derived enzymatic products, namely 5'-deoxyadenosine, S-adenosyl-L-homocysteine, and 5'- methylthioadenosine, to produce the inosine analogs. Can also deaminate adenosine. The preferred substrate for this enzyme is 5'- deoxyadenosine, but all these substrates are efficiently deaminated. Likely functions in a S-adenosyl-L-methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. May also be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose m [...] (441 aa)
thiLThiamine monphosphate kinase ThiL; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (413 aa)
YLM1_1703Acetolactate synthase large subunit IlvB. (582 aa)
YLM1_1723Cysteine synthase CysKM. (319 aa)
bioBBiotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (325 aa)
bioDDethiobiotin synthase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (232 aa)
YLM1_1796Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (451 aa)
Your Current Organism:
Methanobrevibacter olleyae
NCBI taxonomy Id: 294671
Other names: DSM 16632, M. olleyae, Methanobrevibacter olleyae Rea et al. 2007, Methanobrevibacter sp. KM1H5-1P, OCM 841, strain KM1H5-1P
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.