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nop10 nop10 rpl44e rpl44e rpl21e rpl21e YLM1_1592 YLM1_1592 YLM1_1605 YLM1_1605 YLM1_1610 YLM1_1610 YLM1_1649 YLM1_1649 YLM1_1684 YLM1_1684 YLM1_1692 YLM1_1692 YLM1_1757 YLM1_1757 YLM1_0057 YLM1_0057 rps19e rps19e rpl31e rpl31e YLM1_0086 YLM1_0086 YLM1_0090 YLM1_0090 rps3ae rps3ae rpl10 rpl10 rpl12 rpl12 YLM1_0224 YLM1_0224 YLM1_0281 YLM1_0281 dnaG dnaG cobB cobB YLM1_0355 YLM1_0355 YLM1_0368 YLM1_0368 YLM1_0379 YLM1_0379 YLM1_0382 YLM1_0382 YLM1_0412 YLM1_0412 YLM1_0436 YLM1_0436 rps19p rps19p rps3 rps3 rpl29 rpl29 rps17 rps17 rps4e rps4e rpl6 rpl6 YLM1_0455 YLM1_0455 rpl19e rpl19e rpl18 rpl18 rps5 rps5 rpl34e rpl34e truB truB rps4 rps4 rps2 rps2 priL priL priS priS YLM1_0603 YLM1_0603 YLM1_0632 YLM1_0632 YLM1_0686 YLM1_0686 YLM1_0687 YLM1_0687 YLM1_0688 YLM1_0688 YLM1_0726 YLM1_0726 YLM1_0727 YLM1_0727 YLM1_0728 YLM1_0728 rfcS rfcS rfcL rfcL YLM1_0760 YLM1_0760 rad50 rad50 mre11 mre11 rpl40e rpl40e pdxS pdxS rpl37ae rpl37ae rpl15e rpl15e YLM1_0853 YLM1_0853 rps24e rps24e rps6e rps6e rpl24e rpl24e rps28e rps28e YLM1_0991 YLM1_0991 nth nth YLM1_1067 YLM1_1067 rps17e rps17e YLM1_1154 YLM1_1154 YLM1_1185 YLM1_1185 YLM1_1187 YLM1_1187 YLM1_1258 YLM1_1258 YLM1_1259 YLM1_1259 rps10 rps10 rpl30e rpl30e top6A top6A YLM1_1328 YLM1_1328 YLM1_1426 YLM1_1426 flpA flpA dnaJ dnaJ YLM1_1490 YLM1_1490
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nop10H/ACA RNA-protein complex component Nop10p; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (56 aa)
rpl44eRibosomal protein L44e Rpl44e; Binds to the 23S rRNA. (92 aa)
rpl21eRibosomal protein L21e Rpl21e; Belongs to the eukaryotic ribosomal protein eL21 family. (96 aa)
YLM1_1592Archaeal ATPase. (396 aa)
YLM1_1605Archaeal histone. (67 aa)
YLM1_1610Cdc6 family replication initiation protein Cdc6-1; Involved in regulation of DNA replication. (389 aa)
YLM1_1649Hypothetical protein. (234 aa)
YLM1_1684Hypothetical protein. (256 aa)
YLM1_1692Transcriptional regulator. (270 aa)
YLM1_1757DNA modification methylase. (379 aa)
YLM1_0057Adenylate cyclase CyaA. (182 aa)
rps19eRibosomal protein S19e Rps19e; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (146 aa)
rpl31eRibosomal protein L31e Rpl31e; Belongs to the ribosomal protein L31e family. (86 aa)
YLM1_0086Metallophosphoesterase. (359 aa)
YLM1_0090Cdc6 family replication initiation protein Cdc6-2; Involved in regulation of DNA replication. (372 aa)
rps3aeRibosomal protein S3Ae Rps3ae; Belongs to the eukaryotic ribosomal protein eS1 family. (193 aa)
rpl10Acidic ribosomal protein P0 RplPO; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (334 aa)
rpl12Ribosomal protein L12P Rpl12p; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (105 aa)
YLM1_0224MoxR-like ATPase. (290 aa)
YLM1_0281PMBR domain-containing protein. (368 aa)
dnaGDNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (453 aa)
cobBNAD-dependent protein deacetylase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. (242 aa)
YLM1_0355H/ACA RNA-protein complex component Gar1. (119 aa)
YLM1_0368FHA domain-containing protein. (266 aa)
YLM1_0379Archaeal ATPase. (398 aa)
YLM1_0382Archaeal ATPase. (393 aa)
YLM1_0412Adhesin-like protein with transglutaminase and PMBR domains. (590 aa)
YLM1_0436Hypothetical protein. (271 aa)
rps19pRibosomal protein S19P Rps19p; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (136 aa)
rps3Ribosomal protein S3P Rps3p; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (253 aa)
rpl29Ribosomal protein L29P Rpl29p; Belongs to the universal ribosomal protein uL29 family. (68 aa)
rps17Ribosomal protein S17P Rps17p; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (106 aa)
rps4eRibosomal protein S4e Rps4e; Belongs to the eukaryotic ribosomal protein eS4 family. (244 aa)
rpl6Ribosomal protein L6P Rpl6p; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (177 aa)
YLM1_0455Ribosomal protein L32e Rpl32e. (108 aa)
rpl19eRibosomal protein L19e Rpl19e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (148 aa)
rpl18Ribosomal protein L18P Rpl18p; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (193 aa)
rps5Ribosomal protein S5P Rps5p; With S4 and S12 plays an important role in translational accuracy. (213 aa)
rpl34eRibosomal protein L34e Rpl34e; Belongs to the eukaryotic ribosomal protein eL34 family. (88 aa)
truBH/ACA RNA-protein complex component Cbf5p; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (320 aa)
rps4Ribosomal protein S4P Rps4p; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (178 aa)
rps2Ribosomal protein S2P Rps2p; Belongs to the universal ribosomal protein uS2 family. (198 aa)
priLDNA primase large subunit PriB; Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. (464 aa)
priSDNA primase small subunit PriA; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthe [...] (330 aa)
YLM1_0603Adhesin-like protein. (1124 aa)
YLM1_0632HD domain-containing protein. (405 aa)
YLM1_0686TPR repeat-containing protein. (402 aa)
YLM1_0687TPR repeat-containing protein. (258 aa)
YLM1_0688Archaeal ATPase. (118 aa)
YLM1_0726TPR repeat-containing protein. (397 aa)
YLM1_0727Restriction endonuclease. (258 aa)
YLM1_0728Hypothetical protein. (432 aa)
rfcSReplication factor C small subunit RfcS; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (314 aa)
rfcLReplication factor C large subunit RfcL; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (524 aa)
YLM1_0760TrmB family transcriptional regulator. (255 aa)
rad50DNA double-strand break repair protein Rad50; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. (928 aa)
mre11DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. (459 aa)
rpl40eRibosomal protein L40e Rpl40e; Belongs to the eukaryotic ribosomal protein eL40 family. (48 aa)
pdxSPyridoxal 5'-phosphate synthase subunit Pdx1; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (293 aa)
rpl37aeRibosomal protein L37Ae Rpl37ae; Binds to the 23S rRNA. (89 aa)
rpl15eRibosomal protein L15e Rpl15e; Belongs to the eukaryotic ribosomal protein eL15 family. (183 aa)
YLM1_0853Archaeal ATPase. (394 aa)
rps24eRibosomal protein S24e Rps24e; Belongs to the eukaryotic ribosomal protein eS24 family. (105 aa)
rps6eRibosomal protein S6e Rps6e; Belongs to the eukaryotic ribosomal protein eS6 family. (128 aa)
rpl24eRibosomal protein L24e Rpl24e; Binds to the 23S rRNA. (53 aa)
rps28eRibosomal protein S28e Rps28e; Belongs to the eukaryotic ribosomal protein eS28 family. (68 aa)
YLM1_0991Archaeal histone. (65 aa)
nthEndonuclease III Nth; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (210 aa)
YLM1_1067ADP-ribosylglycohydrolase family protein. (261 aa)
rps17eRibosomal protein S17e Rps17e; Belongs to the eukaryotic ribosomal protein eS17 family. (65 aa)
YLM1_1154Archaeal histone. (66 aa)
YLM1_1185GTP-binding protein. (351 aa)
YLM1_1187Archaeal histone. (67 aa)
YLM1_1258Adhesin-like protein with PMBR domain protein. (418 aa)
YLM1_1259Hypothetical protein. (314 aa)
rps10Ribosomal protein S10P Rps10p; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (101 aa)
rpl30eRibosomal protein L30e Rpl30e; Belongs to the eukaryotic ribosomal protein eL30 family. (94 aa)
top6ADNA topoisomerase VI subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (367 aa)
YLM1_1328N-acetyl neuramic acid synthetase NeuB. (356 aa)
YLM1_1426pre-mRNA splicing ribonucleoprotein PRP31. (408 aa)
flpAFibrillarin FlpA; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (223 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (387 aa)
YLM1_1490Alpha/beta family hydrolase. (324 aa)
Your Current Organism:
Methanobrevibacter olleyae
NCBI taxonomy Id: 294671
Other names: DSM 16632, M. olleyae, Methanobrevibacter olleyae Rea et al. 2007, Methanobrevibacter sp. KM1H5-1P, OCM 841, strain KM1H5-1P
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