STRINGSTRING
PGUG_00037 PGUG_00037 PGUG_00067 PGUG_00067 PGUG_00120 PGUG_00120 PGUG_00194 PGUG_00194 PGUG_00302 PGUG_00302 PGUG_00319 PGUG_00319 PGUG_00322 PGUG_00322 PGUG_00348 PGUG_00348 PGUG_00359 PGUG_00359 PGUG_00408 PGUG_00408 PGUG_00452 PGUG_00452 PGUG_00511 PGUG_00511 PGUG_00649 PGUG_00649 PGUG_00764 PGUG_00764 PGUG_00851 PGUG_00851 PGUG_00860 PGUG_00860 PGUG_00882 PGUG_00882 PGUG_00892 PGUG_00892 PGUG_00905 PGUG_00905 PGUG_00958 PGUG_00958 FEN1 FEN1 PGUG_00991 PGUG_00991 PGUG_01101 PGUG_01101 PGUG_01103 PGUG_01103 PGUG_01242 PGUG_01242 PGUG_01245 PGUG_01245 PGUG_01246 PGUG_01246 PGUG_01269 PGUG_01269 NTG1 NTG1 PGUG_01299 PGUG_01299 CSM3 CSM3 PGUG_01358 PGUG_01358 PGUG_01392 PGUG_01392 PGUG_01394 PGUG_01394 PGUG_01396 PGUG_01396 PGUG_01499 PGUG_01499 PGUG_01500 PGUG_01500 PGUG_01549 PGUG_01549 PGUG_01574 PGUG_01574 PGUG_01612 PGUG_01612 PGUG_01613 PGUG_01613 PGUG_01764 PGUG_01764 PGUG_01790 PGUG_01790 MSH3 MSH3 PGUG_01869 PGUG_01869 PGUG_01964 PGUG_01964 PGUG_01965 PGUG_01965 PGUG_02074 PGUG_02074 MCM7 MCM7 PGUG_02273 PGUG_02273 PGUG_02276 PGUG_02276 PGUG_02306 PGUG_02306 PGUG_02378 PGUG_02378 PGUG_02423 PGUG_02423 PGUG_02429 PGUG_02429 PGUG_02502 PGUG_02502 PGUG_02523 PGUG_02523 PGUG_02616 PGUG_02616 PGUG_02713 PGUG_02713 PGUG_02715 PGUG_02715 PGUG_02762 PGUG_02762 PGUG_02812 PGUG_02812 PGUG_02820 PGUG_02820 PGUG_02862 PGUG_02862 PGUG_02934 PGUG_02934 PGUG_02937 PGUG_02937 PGUG_02963 PGUG_02963 PGUG_02983 PGUG_02983 PGUG_03039 PGUG_03039 PGUG_03102 PGUG_03102 PGUG_03103 PGUG_03103 PGUG_03104 PGUG_03104 PGUG_03182 PGUG_03182 PGUG_03193 PGUG_03193 PGUG_03197 PGUG_03197 PGUG_03198 PGUG_03198 PGUG_03222 PGUG_03222 PGUG_03230 PGUG_03230 PGUG_03302 PGUG_03302 PGUG_03308 PGUG_03308 TOF1 TOF1 PGUG_03500 PGUG_03500 PGUG_03526 PGUG_03526 PGUG_03581 PGUG_03581 PGUG_03585 PGUG_03585 PGUG_03649 PGUG_03649 PGUG_03677 PGUG_03677 PGUG_03863 PGUG_03863 PGUG_03865 PGUG_03865 PGUG_03869 PGUG_03869 PGUG_03934 PGUG_03934 PGUG_04124 PGUG_04124 PGUG_04126 PGUG_04126 PGUG_04139 PGUG_04139 PGUG_04165 PGUG_04165 PGUG_04172 PGUG_04172 PGUG_04183 PGUG_04183 PGUG_04191 PGUG_04191 PGUG_04234 PGUG_04234 PGUG_04275 PGUG_04275 PGUG_04297 PGUG_04297 PGUG_04361 PGUG_04361 PGUG_04464 PGUG_04464 PGUG_04487 PGUG_04487 PGUG_04545 PGUG_04545 PGUG_04643 PGUG_04643 PGUG_04652 PGUG_04652 PGUG_04662 PGUG_04662 PGUG_04666 PGUG_04666 PGUG_04669 PGUG_04669 PGUG_04707 PGUG_04707 PGUG_04794 PGUG_04794 PGUG_04837 PGUG_04837 UNG1 UNG1 PGUG_04953 PGUG_04953 PGUG_05058 PGUG_05058 PGUG_05145 PGUG_05145 PGUG_05154 PGUG_05154 PGUG_05207 PGUG_05207 PGUG_05238 PGUG_05238 PGUG_05249 PGUG_05249 PGUG_05311 PGUG_05311 PGUG_05350 PGUG_05350 PGUG_05408 PGUG_05408 PGUG_05487 PGUG_05487 PGUG_05544 PGUG_05544 PGUG_05597 PGUG_05597 PGUG_05709 PGUG_05709 PGUG_05721 PGUG_05721 PGUG_05750 PGUG_05750 PGUG_05824 PGUG_05824 PGUG_05853 PGUG_05853 TOP2 TOP2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PGUG_00037Ku domain-containing protein. (558 aa)
PGUG_00067DNA polymerase. (1075 aa)
PGUG_00120DNA_pol_E_B domain-containing protein. (639 aa)
PGUG_00194Sld5 domain-containing protein. (153 aa)
PGUG_00302zf-C2HE domain-containing protein. (242 aa)
PGUG_00319Uncharacterized protein. (399 aa)
PGUG_00322DNA_MISMATCH_REPAIR_2 domain-containing protein. (925 aa)
PGUG_00348DNA helicase; Belongs to the MCM family. (853 aa)
PGUG_00359Sld5 domain-containing protein. (216 aa)
PGUG_00408tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (265 aa)
PGUG_00452RPA_C domain-containing protein. (251 aa)
PGUG_00511DNA primase; Belongs to the eukaryotic-type primase small subunit family. (464 aa)
PGUG_00649AAA_23 domain-containing protein. (1302 aa)
PGUG_00764CBFD_NFYB_HMF domain-containing protein. (273 aa)
PGUG_00851C2H2-type domain-containing protein. (461 aa)
PGUG_00860DNA polymerase. (1438 aa)
PGUG_00882FPG_CAT domain-containing protein. (386 aa)
PGUG_00892Uncharacterized protein. (378 aa)
PGUG_00905POLAc domain-containing protein. (1209 aa)
PGUG_00958AP_endonuc_2 domain-containing protein. (360 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (374 aa)
PGUG_00991BRCT domain-containing protein. (708 aa)
PGUG_01101Uncharacterized protein. (756 aa)
PGUG_01103AAA domain-containing protein. (327 aa)
PGUG_01242XPGI domain-containing protein. (632 aa)
PGUG_01245Uncharacterized protein. (229 aa)
PGUG_01246ATP-dependent DNA helicase; Belongs to the helicase family. (426 aa)
PGUG_01269BRCT domain-containing protein. (838 aa)
NTG1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (455 aa)
PGUG_01299SLD3 domain-containing protein. (727 aa)
CSM3Chromosome segregation in meiosis protein 3; Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (210 aa)
PGUG_01358Uncharacterized protein. (402 aa)
PGUG_01392Uncharacterized protein. (888 aa)
PGUG_01394Lactamase_B domain-containing protein. (651 aa)
PGUG_01396Uncharacterized protein. (777 aa)
PGUG_01499ERCC4 domain-containing protein. (1020 aa)
PGUG_01500RMI1_N domain-containing protein. (174 aa)
PGUG_01549ENDO3c domain-containing protein. (333 aa)
PGUG_01574Uncharacterized protein. (135 aa)
PGUG_01612AAA_16 domain-containing protein. (482 aa)
PGUG_01613DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2208 aa)
PGUG_01764Uncharacterized protein. (105 aa)
PGUG_01790RECA_2 domain-containing protein. (504 aa)
MSH3DNA mismatch repair protein MSH3; Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate- binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch bindi [...] (960 aa)
PGUG_01869Ku domain-containing protein. (712 aa)
PGUG_01964Uncharacterized protein. (859 aa)
PGUG_01965HORMA domain-containing protein. (229 aa)
PGUG_02074Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (469 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (797 aa)
PGUG_02273Uncharacterized protein. (293 aa)
PGUG_02276DNA helicase; Belongs to the MCM family. (766 aa)
PGUG_02306DNA_MISMATCH_REPAIR_2 domain-containing protein. (921 aa)
PGUG_02378Uncharacterized protein. (830 aa)
PGUG_02423Uncharacterized protein. (466 aa)
PGUG_02429Uncharacterized protein. (130 aa)
PGUG_02502DNA_mis_repair domain-containing protein. (678 aa)
PGUG_02523Uncharacterized protein. (1035 aa)
PGUG_02616F-box domain-containing protein. (711 aa)
PGUG_02713CBFD_NFYB_HMF domain-containing protein. (234 aa)
PGUG_02715Uncharacterized protein. (1155 aa)
PGUG_02762Cell division control protein; Belongs to the CDC6/cdc18 family. (538 aa)
PGUG_02812Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2316 aa)
PGUG_02820Rep_fac_C domain-containing protein. (256 aa)
PGUG_02862Uncharacterized protein. (1403 aa)
PGUG_02934ERCC4 domain-containing protein. (601 aa)
PGUG_02937Uncharacterized protein. (423 aa)
PGUG_02963ATPase_AAA_core domain-containing protein. (926 aa)
PGUG_02983DNA ligase. (937 aa)
PGUG_03039Uncharacterized protein. (487 aa)
PGUG_03102Pol_alpha_B_N domain-containing protein. (193 aa)
PGUG_03103DNA_pol_E_B domain-containing protein. (213 aa)
PGUG_03104Uncharacterized protein. (176 aa)
PGUG_03182MutL_C domain-containing protein. (693 aa)
PGUG_03193DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1198 aa)
PGUG_03197Uncharacterized protein. (288 aa)
PGUG_03198Uncharacterized protein. (262 aa)
PGUG_03222Fungal_trans domain-containing protein. (756 aa)
PGUG_03230DNA helicase; Belongs to the MCM family. (902 aa)
PGUG_03302MRC1 domain-containing protein. (1029 aa)
PGUG_03308Uncharacterized protein. (713 aa)
TOF1Topoisomerase 1-associated factor 1; Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity). (1216 aa)
PGUG_03500Sld5 domain-containing protein. (172 aa)
PGUG_03526DNA ligase. (731 aa)
PGUG_03581Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (798 aa)
PGUG_03585ORC_WH_C domain-containing protein. (677 aa)
PGUG_03649Uncharacterized protein. (1117 aa)
PGUG_03677Uncharacterized protein. (635 aa)
PGUG_03863MCM domain-containing protein; Belongs to the MCM family. (451 aa)
PGUG_03865Uncharacterized protein. (495 aa)
PGUG_03869DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (333 aa)
PGUG_03934Fungal_trans domain-containing protein. (546 aa)
PGUG_04124DNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (492 aa)
PGUG_04126CDT1_C domain-containing protein. (304 aa)
PGUG_04139DNA helicase; Belongs to the MCM family. (837 aa)
PGUG_04165DNA polymerase. (1593 aa)
PGUG_04172Uncharacterized protein. (169 aa)
PGUG_04183AAA domain-containing protein. (347 aa)
PGUG_04191Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (641 aa)
PGUG_04234UDG domain-containing protein. (299 aa)
PGUG_04275DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (754 aa)
PGUG_04297Uncharacterized protein. (543 aa)
PGUG_04361DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (616 aa)
PGUG_04464FHA domain-containing protein. (422 aa)
PGUG_04487ENDO3c domain-containing protein. (400 aa)
PGUG_04545Uncharacterized protein. (658 aa)
PGUG_04643WLM domain-containing protein. (266 aa)
PGUG_04652Uncharacterized protein. (445 aa)
PGUG_04662Uncharacterized protein. (537 aa)
PGUG_04666DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1098 aa)
PGUG_04669XPA_C domain-containing protein. (375 aa)
PGUG_04707Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (769 aa)
PGUG_04794Uncharacterized protein. (375 aa)
PGUG_04837Uncharacterized protein. (1176 aa)
UNG1Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (347 aa)
PGUG_04953Uncharacterized protein. (766 aa)
PGUG_05058Uncharacterized protein. (634 aa)
PGUG_05145Uncharacterized protein. (631 aa)
PGUG_05154Uncharacterized protein. (319 aa)
PGUG_05207AAA domain-containing protein. (362 aa)
PGUG_05238Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (311 aa)
PGUG_05249Uncharacterized protein. (1133 aa)
PGUG_05311Protein kinase domain-containing protein. (554 aa)
PGUG_05350Uncharacterized protein. (346 aa)
PGUG_05408AAA domain-containing protein. (424 aa)
PGUG_05487Mcl1_mid domain-containing protein. (813 aa)
PGUG_05544Uncharacterized protein. (370 aa)
PGUG_05597Uncharacterized protein. (814 aa)
PGUG_05709AAA domain-containing protein. (796 aa)
PGUG_05721DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (227 aa)
PGUG_05750Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2724 aa)
PGUG_05824DBF4-type domain-containing protein. (482 aa)
PGUG_05853Zf-primase domain-containing protein. (500 aa)
TOP2DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks; Belongs to the type II topoisomerase family. (1400 aa)
Your Current Organism:
Meyerozyma guilliermondii
NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260
Server load: low (14%) [HD]
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