(11 nodes) DNA damage checkpoint signaling network (Meyerozyma guilliermondii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PGUG_01269	BRCT domain-containing protein. (838 aa)
	PGUG_01358	Uncharacterized protein. (402 aa)
	PGUG_02273	Uncharacterized protein. (293 aa)
	PGUG_02812	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2316 aa)
	PGUG_03197	Uncharacterized protein. (288 aa)
	PGUG_03198	Uncharacterized protein. (262 aa)
	PGUG_03302	MRC1 domain-containing protein. (1029 aa)
	PGUG_03308	Uncharacterized protein. (713 aa)
	PGUG_03581	Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. (798 aa)
	PGUG_04652	Uncharacterized protein. (445 aa)
	PGUG_05750	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2724 aa)

Your Current Organism:

Meyerozyma guilliermondii

NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PGUG_01269	PGUG_01358	A5DDB8	A5DDK7	BRCT domain-containing protein.	Uncharacterized protein.	0.753
PGUG_01269	PGUG_02273	A5DDB8	A5DG72	BRCT domain-containing protein.	Uncharacterized protein.	0.768
PGUG_01269	PGUG_02812	A5DDB8	A5DHR1	BRCT domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.990
PGUG_01269	PGUG_03197	A5DDB8	A5DIU6	BRCT domain-containing protein.	Uncharacterized protein.	0.553
PGUG_01269	PGUG_03198	A5DDB8	A5DIU7	BRCT domain-containing protein.	Uncharacterized protein.	0.780
PGUG_01269	PGUG_03302	A5DDB8	A5DJ51	BRCT domain-containing protein.	MRC1 domain-containing protein.	0.829
PGUG_01269	PGUG_03308	A5DDB8	A5DJ57	BRCT domain-containing protein.	Uncharacterized protein.	0.927
PGUG_01269	PGUG_03581	A5DDB8	A5DJY0	BRCT domain-containing protein.	Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.	0.998
PGUG_01269	PGUG_04652	A5DDB8	A5DN01	BRCT domain-containing protein.	Uncharacterized protein.	0.701
PGUG_01269	PGUG_05750	A5DDB8	A5DR49	BRCT domain-containing protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.955
PGUG_01358	PGUG_01269	A5DDK7	A5DDB8	Uncharacterized protein.	BRCT domain-containing protein.	0.753
PGUG_01358	PGUG_02273	A5DDK7	A5DG72	Uncharacterized protein.	Uncharacterized protein.	0.999
PGUG_01358	PGUG_02812	A5DDK7	A5DHR1	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.984
PGUG_01358	PGUG_03197	A5DDK7	A5DIU6	Uncharacterized protein.	Uncharacterized protein.	0.924
PGUG_01358	PGUG_03198	A5DDK7	A5DIU7	Uncharacterized protein.	Uncharacterized protein.	0.934
PGUG_01358	PGUG_03302	A5DDK7	A5DJ51	Uncharacterized protein.	MRC1 domain-containing protein.	0.614
PGUG_01358	PGUG_03581	A5DDK7	A5DJY0	Uncharacterized protein.	Serine/threonine-protein kinase RAD53; Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.	0.650
PGUG_01358	PGUG_04652	A5DDK7	A5DN01	Uncharacterized protein.	Uncharacterized protein.	0.999
PGUG_01358	PGUG_05750	A5DDK7	A5DR49	Uncharacterized protein.	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily.	0.876
PGUG_02273	PGUG_01269	A5DG72	A5DDB8	Uncharacterized protein.	BRCT domain-containing protein.	0.768