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PGUG_00365 PGUG_00365 PGUG_00485 PGUG_00485 TIF1 TIF1 PGUG_00713 PGUG_00713 PGUG_00899 PGUG_00899 PGUG_01266 PGUG_01266 PGUG_01401 PGUG_01401 PGUG_01407 PGUG_01407 PGUG_01483 PGUG_01483 PGUG_02021 PGUG_02021 PGUG_02247 PGUG_02247 TIF34 TIF34 TIF32 TIF32 HCR1 HCR1 PGUG_03082 PGUG_03082 PGUG_03466 PGUG_03466 PGUG_03746 PGUG_03746 PGUG_03794 PGUG_03794 PGUG_03826 PGUG_03826 PAB1 PAB1 PGUG_04403 PGUG_04403 PGUG_04673 PGUG_04673 TIF35 TIF35 NIP1 NIP1 PGUG_05410 PGUG_05410 DED1 DED1 PGUG_05718 PGUG_05718 PRT1 PRT1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PGUG_00365Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (318 aa)
PGUG_00485S1 motif domain-containing protein. (301 aa)
TIF1ATP-dependent RNA helicase eIF4A; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (396 aa)
PGUG_00713Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (288 aa)
PGUG_00899RRM domain-containing protein. (396 aa)
PGUG_01266MPN domain-containing protein. (371 aa)
PGUG_01401S1-like domain-containing protein; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. (153 aa)
PGUG_01407Uncharacterized protein. (199 aa)
PGUG_01483Uncharacterized protein. (399 aa)
PGUG_02021S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family. (251 aa)
PGUG_02247Uncharacterized protein; Belongs to the eIF-2B alpha/beta/delta subunits family. (512 aa)
TIF34Eukaryotic translation initiation factor 3 subunit I; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (348 aa)
TIF32Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (891 aa)
HCR1Eukaryotic translation initiation factor 3 subunit J; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (279 aa)
PGUG_03082W2 domain-containing protein. (402 aa)
PGUG_03466Uncharacterized protein. (139 aa)
PGUG_03746MIF4G domain-containing protein. (698 aa)
PGUG_03794Uncharacterized protein. (94 aa)
PGUG_03826NTP_transf_3 domain-containing protein. (458 aa)
PAB1Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] (631 aa)
PGUG_04403W2 domain-containing protein. (678 aa)
PGUG_04673eIF2B_5 domain-containing protein. (301 aa)
TIF35Eukaryotic translation initiation factor 3 subunit G; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. (274 aa)
NIP1Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (836 aa)
PGUG_05410Eukaryotic translation initiation factor 2 gamma subunit. (548 aa)
DED1ATP-dependent RNA helicase DED1; ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity). Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. (637 aa)
PGUG_05718Uncharacterized protein; Belongs to the eukaryotic initiation factor 4E family. (207 aa)
PRT1Eukaryotic translation initiation factor 3 subunit B; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. (738 aa)
Your Current Organism:
Meyerozyma guilliermondii
NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260
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