(46 nodes) Small-subunit processome, and rRNA processing network (Meyerozyma guilliermondii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PGUG_00031	WD_REPEATS_REGION domain-containing protein. (498 aa)
	PGUG_00040	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA. (243 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1043 aa)
	PGUG_00433	Uncharacterized protein. (373 aa)
	PGUG_00659	WD_REPEATS_REGION domain-containing protein. (632 aa)
	PGUG_00686	Bms1-type G domain-containing protein. (1177 aa)
	PGUG_00800	WD_REPEATS_REGION domain-containing protein. (912 aa)
	PGUG_00866	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
	PGUG_01043	Uncharacterized protein. (330 aa)
	PGUG_01184	Fcf2 domain-containing protein. (193 aa)
	PGUG_01273	WD_REPEATS_REGION domain-containing protein. (780 aa)
	PGUG_01287	WD_REPEATS_REGION domain-containing protein. (956 aa)
	PGUG_01349	Utp12 domain-containing protein. (547 aa)
	PGUG_01600	Uncharacterized protein. (859 aa)
	PGUG_01694	WD_REPEATS_REGION domain-containing protein. (487 aa)
	PGUG_01827	Uncharacterized protein. (775 aa)
	UTP25	U3 small nucleolar RNA-associated protein 25; DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2. (716 aa)
	PGUG_01983	Brix domain-containing protein. (302 aa)
	UTP10	U3 small nucleolar RNA-associated protein 10; Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity). (1819 aa)
	PGUG_02565	S4 RNA-binding domain-containing protein. (183 aa)
	PGUG_02622	Uncharacterized protein. (709 aa)
	PGUG_02711	Uncharacterized protein. (789 aa)
	PGUG_02826	PINc domain-containing protein. (214 aa)
	NOP58	Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family. (504 aa)
	PGUG_02877	Nop domain-containing protein. (509 aa)
	PGUG_02990	Utp12 domain-containing protein. (429 aa)
	PGUG_03001	Uncharacterized protein. (282 aa)
	ROK1	ATP-dependent RNA helicase ROK1; ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA. (537 aa)
	PGUG_03304	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (340 aa)
	PGUG_03307	Nucleolar essential protein 1. (247 aa)
	PGUG_03539	Uncharacterized protein. (832 aa)
	PGUG_03573	WD_REPEATS_REGION domain-containing protein. (461 aa)
	PGUG_04053	WD_REPEATS_REGION domain-containing protein. (783 aa)
	DBP8	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily. (433 aa)
	PGUG_04107	Sas10 domain-containing protein. (554 aa)
	PGUG_04138	CBF domain-containing protein. (532 aa)
	PGUG_04177	WD_REPEATS_REGION domain-containing protein. (522 aa)
	PGUG_04405	TPR_REGION domain-containing protein. (317 aa)
	PGUG_04921	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (583 aa)
	PGUG_05282	Uncharacterized protein. (1674 aa)
	PGUG_05318	U3 small nucleolar RNA-associated protein 22. (1161 aa)
	PGUG_05431	Uncharacterized protein. (511 aa)
	PGUG_05474	Uncharacterized protein. (309 aa)
	RRP3	ATP-dependent rRNA helicase RRP3; Required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA (By similarity). (475 aa)
	PGUG_05625	WD_REPEATS_REGION domain-containing protein. (673 aa)
	PGUG_05716	Uncharacterized protein. (560 aa)

Your Current Organism:

Meyerozyma guilliermondii

NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DBP8	NAT10	A5DLE0	A5DAN3	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.	0.659
DBP8	NOP58	A5DLE0	A5DHW0	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Nucleolar protein 58; Required for pre-18S rRNA processing. May bind microtubules (By similarity); Belongs to the NOP5/NOP56 family.	0.541
DBP8	PGUG_00031	A5DLE0	A5D9S6	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	WD_REPEATS_REGION domain-containing protein.	0.821
DBP8	PGUG_00040	A5DLE0	A5D9T5	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	U3 small nucleolar RNA-associated protein 11; Involved in nucleolar processing of pre-18S ribosomal RNA.	0.980
DBP8	PGUG_00433	A5DLE0	A5DAX8	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Uncharacterized protein.	0.616
DBP8	PGUG_00659	A5DLE0	A5DBK4	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	WD_REPEATS_REGION domain-containing protein.	0.728
DBP8	PGUG_00686	A5DLE0	A5DBN1	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Bms1-type G domain-containing protein.	0.730
DBP8	PGUG_00800	A5DLE0	A5DBZ5	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	WD_REPEATS_REGION domain-containing protein.	0.620
DBP8	PGUG_01043	A5DLE0	A5DCN8	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Uncharacterized protein.	0.845
DBP8	PGUG_01273	A5DLE0	A5DDC2	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	WD_REPEATS_REGION domain-containing protein.	0.636
DBP8	PGUG_01287	A5DLE0	A5DDD6	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	WD_REPEATS_REGION domain-containing protein.	0.515
DBP8	PGUG_01349	A5DLE0	A5DDJ8	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Utp12 domain-containing protein.	0.718
DBP8	PGUG_01600	A5DLE0	A5DE99	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Uncharacterized protein.	0.825
DBP8	PGUG_01694	A5DLE0	A5DEJ3	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	WD_REPEATS_REGION domain-containing protein.	0.988
DBP8	PGUG_01827	A5DLE0	A5DEX6	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Uncharacterized protein.	0.983
DBP8	PGUG_01983	A5DLE0	A5DFD2	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Brix domain-containing protein.	0.636
DBP8	PGUG_02565	A5DLE0	A5DH14	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	S4 RNA-binding domain-containing protein.	0.555
DBP8	PGUG_02622	A5DLE0	A5DH71	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Uncharacterized protein.	0.452
DBP8	PGUG_02711	A5DLE0	A5DHG0	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	Uncharacterized protein.	0.871
DBP8	PGUG_02826	A5DLE0	A5DHS5	ATP-dependent RNA helicase DBP8; ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity); Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.	PINc domain-containing protein.	0.976