(49 nodes) Cellular amino acid biosynthetic process network (Meyerozyma guilliermondii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:
	PGUG_00207	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family. (589 aa)
	PGUG_00240	Uncharacterized protein. (518 aa)
	PGUG_00476	Chorismate mutase. (267 aa)
	PGUG_00514	Uncharacterized protein. (276 aa)
	PGUG_00520	Uncharacterized protein. (585 aa)
	PGUG_00676	Acetolactate synthase. (681 aa)
	PGUG_00730	Semialdhyde_dh domain-containing protein. (362 aa)
	PGUG_00738	Uncharacterized protein. (251 aa)
	PGUG_01023	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. (216 aa)
	PGUG_01147	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (773 aa)
	PGUG_01364	Aminotran_1_2 domain-containing protein. (400 aa)
	PGUG_01505	Histidine biosynthesis trifunctional protein. (844 aa)
	PGUG_01529	Uncharacterized protein; Belongs to the ketol-acid reductoisomerase family. (404 aa)
	PGUG_01629	Zn(2)-C6 fungal-type domain-containing protein. (967 aa)
	PGUG_01631	ACT domain-containing protein. (291 aa)
	PGUG_01677	Uncharacterized protein. (528 aa)
	PGUG_01716	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (464 aa)
	PGUG_01763	Glutamine amidotransferase type-1 domain-containing protein. (496 aa)
	PGUG_01797	Pyruvate carboxyltransferase domain-containing protein. (524 aa)
	PGUG_01897	Uncharacterized protein. (179 aa)
	PGUG_02078	Aminotran_1_2 domain-containing protein. (487 aa)
	PGUG_02270	Threonine dehydratase. (583 aa)
	PGUG_02272	Aminotran_5 domain-containing protein. (296 aa)
	PGUG_02283	4-hydroxyphenylpyruvate dioxygenase. (309 aa)
	PGUG_02400	Prephenate dehydrogenase [NADP(+)]; Belongs to the prephenate/arogenate dehydrogenase family. (438 aa)
	PGUG_02418	Uncharacterized protein. (847 aa)
	PGUG_02458	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
	PGUG_02577	Aminotran_1_2 domain-containing protein. (402 aa)
	PGUG_03003	Uncharacterized protein. (302 aa)
	PGUG_03416	GHMP_kinases_N domain-containing protein. (350 aa)
	PGUG_03480	Chorismate synthase. (379 aa)
	PGUG_03620	Pyruvate carboxyltransferase domain-containing protein. (590 aa)
	PGUG_03626	PRAI domain-containing protein. (255 aa)
	PGUG_03779	Glutamine amidotransferase type-1 domain-containing protein. (758 aa)
	PGUG_03982	Homoserine dehydrogenase. (385 aa)
	PGUG_03997	Uncharacterized protein. (307 aa)
	PGUG_04024	Aminotran_5 domain-containing protein. (406 aa)
	PGUG_04278	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (382 aa)
	PGUG_04338	Glycos_transf_3 domain-containing protein. (256 aa)
	PGUG_04621	Aminotran_1_2 domain-containing protein. (478 aa)
	PGUG_04681	Uncharacterized protein. (626 aa)
	PGUG_04771	AB hydrolase-1 domain-containing protein. (465 aa)
	PGUG_04828	PALP domain-containing protein. (472 aa)
	PGUG_04906	PALP domain-containing protein. (319 aa)
	PGUG_04966	PALP domain-containing protein. (355 aa)
	PGUG_05378	Aspartokinase. (528 aa)
	PGUG_05380	Aminotran_1_2 domain-containing protein. (511 aa)
	PGUG_05396	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (267 aa)
	PGUG_05631	Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (312 aa)

Your Current Organism:

Meyerozyma guilliermondii

NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PGUG_00207	PGUG_00514	A5DAA2	A5DB59	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.991
PGUG_00207	PGUG_00676	A5DAA2	A5DBM1	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Acetolactate synthase.	0.498
PGUG_00207	PGUG_00738	A5DAA2	A5DBT3	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.920
PGUG_00207	PGUG_01023	A5DAA2	A5DCL8	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family.	0.999
PGUG_00207	PGUG_01147	A5DAA2	A5DCZ2	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.593
PGUG_00207	PGUG_01364	A5DAA2	A5DDL3	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Aminotran_1_2 domain-containing protein.	0.991
PGUG_00207	PGUG_01505	A5DAA2	A5DE04	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Histidine biosynthesis trifunctional protein.	0.999
PGUG_00207	PGUG_01631	A5DAA2	A5DED0	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	ACT domain-containing protein.	0.637
PGUG_00207	PGUG_01677	A5DAA2	A5DEH6	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.459
PGUG_00207	PGUG_01763	A5DAA2	A5DER2	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Glutamine amidotransferase type-1 domain-containing protein.	0.873
PGUG_00207	PGUG_02272	A5DAA2	A5DG71	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Aminotran_5 domain-containing protein.	0.529
PGUG_00207	PGUG_02418	A5DAA2	A5DGL7	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.930
PGUG_00207	PGUG_02458	A5DAA2	A5DGQ7	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.616
PGUG_00207	PGUG_03003	A5DAA2	A5DIA2	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.906
PGUG_00207	PGUG_03626	A5DAA2	A5DK25	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	PRAI domain-containing protein.	0.644
PGUG_00207	PGUG_03779	A5DAA2	A5DKH8	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Glutamine amidotransferase type-1 domain-containing protein.	0.439
PGUG_00207	PGUG_03982	A5DAA2	A5DL31	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Homoserine dehydrogenase.	0.574
PGUG_00207	PGUG_04338	A5DAA2	A5DM37	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Glycos_transf_3 domain-containing protein.	0.618
PGUG_00207	PGUG_04828	A5DAA2	A5DNH7	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	PALP domain-containing protein.	0.913
PGUG_00207	PGUG_05378	A5DAA2	A5DQ27	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Aspartokinase.	0.604