(22 nodes) Valine, leucine and isoleucine biosynthesis, and Threonine biosynthetic process network (Meyerozyma guilliermondii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PGUG_00240	Uncharacterized protein. (518 aa)
	PGUG_00520	Uncharacterized protein. (585 aa)
	PGUG_00676	Acetolactate synthase. (681 aa)
	PGUG_00730	Semialdhyde_dh domain-containing protein. (362 aa)
	PGUG_01147	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (773 aa)
	PGUG_01529	Uncharacterized protein; Belongs to the ketol-acid reductoisomerase family. (404 aa)
	PGUG_01631	ACT domain-containing protein. (291 aa)
	PGUG_01716	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (464 aa)
	PGUG_01797	Pyruvate carboxyltransferase domain-containing protein. (524 aa)
	PGUG_02270	Threonine dehydratase. (583 aa)
	PGUG_02272	Aminotran_5 domain-containing protein. (296 aa)
	PGUG_02458	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (396 aa)
	PGUG_03003	Uncharacterized protein. (302 aa)
	PGUG_03416	GHMP_kinases_N domain-containing protein. (350 aa)
	PGUG_03620	Pyruvate carboxyltransferase domain-containing protein. (590 aa)
	PGUG_03982	Homoserine dehydrogenase. (385 aa)
	PGUG_04024	Aminotran_5 domain-containing protein. (406 aa)
	PGUG_04278	3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (382 aa)
	PGUG_04771	AB hydrolase-1 domain-containing protein. (465 aa)
	PGUG_04906	PALP domain-containing protein. (319 aa)
	PGUG_04966	PALP domain-containing protein. (355 aa)
	PGUG_05378	Aspartokinase. (528 aa)

Your Current Organism:

Meyerozyma guilliermondii

NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PGUG_00240	PGUG_00520	A5DAD5	A5DB65	Uncharacterized protein.	Uncharacterized protein.	0.700
PGUG_00240	PGUG_00676	A5DAD5	A5DBM1	Uncharacterized protein.	Acetolactate synthase.	0.714
PGUG_00240	PGUG_00730	A5DAD5	A5DBS5	Uncharacterized protein.	Semialdhyde_dh domain-containing protein.	0.817
PGUG_00240	PGUG_01147	A5DAD5	A5DCZ2	Uncharacterized protein.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.700
PGUG_00240	PGUG_01631	A5DAD5	A5DED0	Uncharacterized protein.	ACT domain-containing protein.	0.790
PGUG_00240	PGUG_01716	A5DAD5	A5DEL5	Uncharacterized protein.	D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.739
PGUG_00240	PGUG_02270	A5DAD5	A5DG69	Uncharacterized protein.	Threonine dehydratase.	0.982
PGUG_00240	PGUG_02272	A5DAD5	A5DG71	Uncharacterized protein.	Aminotran_5 domain-containing protein.	0.964
PGUG_00240	PGUG_02458	A5DAD5	A5DGQ7	Uncharacterized protein.	Branched-chain-amino-acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.	0.673
PGUG_00240	PGUG_03003	A5DAD5	A5DIA2	Uncharacterized protein.	Uncharacterized protein.	0.891
PGUG_00240	PGUG_03416	A5DAD5	A5DJG5	Uncharacterized protein.	GHMP_kinases_N domain-containing protein.	0.999
PGUG_00240	PGUG_03982	A5DAD5	A5DL31	Uncharacterized protein.	Homoserine dehydrogenase.	0.994
PGUG_00240	PGUG_04024	A5DAD5	A5DL73	Uncharacterized protein.	Aminotran_5 domain-containing protein.	0.597
PGUG_00240	PGUG_04906	A5DAD5	A5DNQ5	Uncharacterized protein.	PALP domain-containing protein.	0.971
PGUG_00240	PGUG_04966	A5DAD5	A5DNW5	Uncharacterized protein.	PALP domain-containing protein.	0.971
PGUG_00240	PGUG_05378	A5DAD5	A5DQ27	Uncharacterized protein.	Aspartokinase.	0.947
PGUG_00520	PGUG_00240	A5DB65	A5DAD5	Uncharacterized protein.	Uncharacterized protein.	0.700
PGUG_00520	PGUG_00676	A5DB65	A5DBM1	Uncharacterized protein.	Acetolactate synthase.	0.989
PGUG_00520	PGUG_00730	A5DB65	A5DBS5	Uncharacterized protein.	Semialdhyde_dh domain-containing protein.	0.706
PGUG_00520	PGUG_01147	A5DB65	A5DCZ2	Uncharacterized protein.	3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.	0.977