STRINGSTRING
PGUG_00457 PGUG_00457 PGUG_00508 PGUG_00508 PGUG_00561 PGUG_00561 PGUG_00570 PGUG_00570 PGUG_00587 PGUG_00587 PGUG_00617 PGUG_00617 PGUG_00651 PGUG_00651 PGUG_00701 PGUG_00701 DUS3 DUS3 PGUG_00737 PGUG_00737 LSM1 LSM1 PGUG_00798 PGUG_00798 PGUG_00836 PGUG_00836 PGUG_00840 PGUG_00840 PGUG_00866 PGUG_00866 PGUG_00876 PGUG_00876 PGUG_00916 PGUG_00916 PGUG_00985 PGUG_00985 PGUG_01037 PGUG_01037 PGUG_01038 PGUG_01038 PGUG_01047 PGUG_01047 PAN3 PAN3 PGUG_01060 PGUG_01060 PGUG_01071 PGUG_01071 PGUG_01100 PGUG_01100 PGUG_01227 PGUG_01227 PRP5 PRP5 PGUG_01309 PGUG_01309 ABD1 ABD1 SUB2 SUB2 PGUG_01386 PGUG_01386 PGUG_01431 PGUG_01431 PGUG_01448 PGUG_01448 PGUG_01460 PGUG_01460 PGUG_01461 PGUG_01461 PGUG_01462 PGUG_01462 PGUG_01475 PGUG_01475 PGUG_01488 PGUG_01488 PGUG_01514 PGUG_01514 PGUG_01538 PGUG_01538 PGUG_01540 PGUG_01540 PGUG_01657 PGUG_01657 SQS1 SQS1 PGUG_01674 PGUG_01674 PGUG_01709 PGUG_01709 PGUG_01727 PGUG_01727 PGUG_01728 PGUG_01728 PGUG_01786 PGUG_01786 PGUG_01813 PGUG_01813 PGUG_01823 PGUG_01823 PGUG_01836 PGUG_01836 MSS116 MSS116 PGUG_01849 PGUG_01849 PGUG_01853 PGUG_01853 PRP28 PRP28 PGUG_01860 PGUG_01860 PGUG_02025 PGUG_02025 PGUG_02043 PGUG_02043 PGUG_02083 PGUG_02083 PGUG_02090 PGUG_02090 PGUG_02139 PGUG_02139 PGUG_02213 PGUG_02213 PGUG_02228 PGUG_02228 PGUG_02274 PGUG_02274 PGUG_02275 PGUG_02275 PGUG_02319 PGUG_02319 PGUG_02328 PGUG_02328 PGUG_02442 PGUG_02442 PGUG_02443 PGUG_02443 PGUG_02446 PGUG_02446 PGUG_02490 PGUG_02490 PGUG_02573 PGUG_02573 PGUG_02678 PGUG_02678 PGUG_02741 PGUG_02741 PGUG_02767 PGUG_02767 PGUG_02772 PGUG_02772 PGUG_02801 PGUG_02801 PGUG_02806 PGUG_02806 PGUG_02815 PGUG_02815 LSM8 LSM8 PGUG_02887 PGUG_02887 PGUG_02919 PGUG_02919 PGUG_02935 PGUG_02935 PGUG_02962 PGUG_02962 PGUG_03049 PGUG_03049 PGUG_03097 PGUG_03097 PGUG_03117 PGUG_03117 DHH1 DHH1 PGUG_03159 PGUG_03159 PGUG_03160 PGUG_03160 PGUG_03205 PGUG_03205 PGUG_03223 PGUG_03223 PGUG_03238 PGUG_03238 PGUG_03321 PGUG_03321 PGUG_03324 PGUG_03324 PGUG_03332 PGUG_03332 PGUG_03372 PGUG_03372 PGUG_03382 PGUG_03382 PGUG_03399 PGUG_03399 PGUG_03402 PGUG_03402 PGUG_03407 PGUG_03407 PGUG_03483 PGUG_03483 PGUG_03510 PGUG_03510 PGUG_03557 PGUG_03557 PGUG_03565 PGUG_03565 CLP1 CLP1 PGUG_03598 PGUG_03598 PGUG_03610 PGUG_03610 PGUG_03660 PGUG_03660 PGUG_03766 PGUG_03766 PGUG_03795 PGUG_03795 PGUG_03992 PGUG_03992 PGUG_04120 PGUG_04120 PGUG_04128 PGUG_04128 PGUG_04132 PGUG_04132 PGUG_04180 PGUG_04180 PGUG_04247 PGUG_04247 PGUG_04251 PGUG_04251 PAB1 PAB1 PGUG_04336 PGUG_04336 PGUG_04337 PGUG_04337 PGUG_00392 PGUG_00392 PGUG_00340 PGUG_00340 YME2 YME2 PGUG_00282 PGUG_00282 PAN2 PAN2 PGUG_00185 PGUG_00185 CCM1 CCM1 PGUG_00149 PGUG_00149 PGUG_00146 PGUG_00146 PGUG_00108 PGUG_00108 PGUG_00096 PGUG_00096 PGUG_00095 PGUG_00095 PGUG_00058 PGUG_00058 PGUG_05766 PGUG_05766 PGUG_05728 PGUG_05728 PGUG_05624 PGUG_05624 PGUG_05527 PGUG_05527 PGUG_05494 PGUG_05494 PGUG_05462 PGUG_05462 PGUG_05446 PGUG_05446 PGUG_05370 PGUG_05370 PGUG_05356 PGUG_05356 PGUG_05276 PGUG_05276 PGUG_05272 PGUG_05272 PGUG_05250 PGUG_05250 PGUG_05130 PGUG_05130 PGUG_05007 PGUG_05007 PGUG_04943 PGUG_04943 PGUG_04846 PGUG_04846 PGUG_04785 PGUG_04785 PGUG_04751 PGUG_04751 PGUG_04749 PGUG_04749 LOT5 LOT5 PGUG_04580 PGUG_04580 PGUG_04457 PGUG_04457 PGUG_04444 PGUG_04444 PGUG_05902 PGUG_05902 PGUG_05818 PGUG_05818 PGUG_00402 PGUG_00402 PGUG_05772 PGUG_05772 PGUG_00426 PGUG_00426
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PGUG_00457Uncharacterized protein. (229 aa)
PGUG_00508Uncharacterized protein. (1115 aa)
PGUG_00561Zn(2)-C6 fungal-type domain-containing protein. (787 aa)
PGUG_00570WD_REPEATS_REGION domain-containing protein. (343 aa)
PGUG_00587Protein kinase domain-containing protein. (667 aa)
PGUG_00617RRM domain-containing protein. (214 aa)
PGUG_00651Uncharacterized protein. (876 aa)
PGUG_00701Spliceosomal protein DIB1; Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis; Belongs to the DIM1 family. (180 aa)
DUS3tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). (607 aa)
PGUG_00737C2H2-type domain-containing protein. (209 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation. (157 aa)
PGUG_00798Uncharacterized protein. (105 aa)
PGUG_00836Uncharacterized protein. (152 aa)
PGUG_00840PWI domain-containing protein. (188 aa)
PGUG_00866Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (126 aa)
PGUG_00876Uncharacterized protein. (551 aa)
PGUG_00916MIF4G domain-containing protein. (929 aa)
PGUG_00985Uncharacterized protein. (199 aa)
PGUG_01037RRM domain-containing protein. (242 aa)
PGUG_01038RRM domain-containing protein. (326 aa)
PGUG_01047Uncharacterized protein. (241 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (620 aa)
PGUG_01060Uncharacterized protein. (487 aa)
PGUG_01071Fip1 domain-containing protein. (278 aa)
PGUG_01100CID domain-containing protein. (442 aa)
PGUG_012275'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (909 aa)
PRP5Pre-mRNA-processing ATP-dependent RNA helicase PRP5; ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity); Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily. (862 aa)
PGUG_01309Slu7 domain-containing protein. (338 aa)
ABD1mRNA cap guanine-N7 methyltransferase; Responsible for methylating the 5'-cap structure of mRNAs. Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family. (580 aa)
SUB2ATP-dependent RNA helicase SUB2; ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 plays also a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity); Belongs to the DEAD box helicase family. DECD subfamily. (432 aa)
PGUG_01386Uncharacterized protein. (238 aa)
PGUG_01431Uncharacterized protein. (886 aa)
PGUG_01448RRM domain-containing protein. (330 aa)
PGUG_01460RPOL4c domain-containing protein. (188 aa)
PGUG_01461Uncharacterized protein. (230 aa)
PGUG_01462Uncharacterized protein. (702 aa)
PGUG_01475Uncharacterized protein. (218 aa)
PGUG_01488Uncharacterized protein. (417 aa)
PGUG_01514NmrA domain-containing protein. (293 aa)
PGUG_01538Uncharacterized protein. (231 aa)
PGUG_01540mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family. (477 aa)
PGUG_01657Uncharacterized protein. (223 aa)
SQS1Protein SQS1; May be involved in splicing; Belongs to the SQS1 family. (749 aa)
PGUG_01674J domain-containing protein. (198 aa)
PGUG_01709RRM domain-containing protein. (141 aa)
PGUG_01727PPIase cyclophilin-type domain-containing protein. (384 aa)
PGUG_01728Protein kinase domain-containing protein. (802 aa)
PGUG_01786Cwf21 domain-containing protein. (155 aa)
PGUG_01813RRM domain-containing protein. (220 aa)
PGUG_01823Uncharacterized protein. (404 aa)
PGUG_01836Uncharacterized protein. (589 aa)
MSS116ATP-dependent RNA helicase MSS116, mitochondrial; ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity); Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. (714 aa)
PGUG_01849RAI1 domain-containing protein. (394 aa)
PGUG_01853Uncharacterized protein. (320 aa)
PRP28Pre-mRNA-splicing ATP-dependent RNA helicase PRP28; ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity). (575 aa)
PGUG_01860Uncharacterized protein. (78 aa)
PGUG_02025Uncharacterized protein. (753 aa)
PGUG_02043CPSF_A domain-containing protein. (1206 aa)
PGUG_02083Uncharacterized protein. (245 aa)
PGUG_02090Prp18 domain-containing protein. (250 aa)
PGUG_02139Uncharacterized protein. (161 aa)
PGUG_02213Uncharacterized protein. (345 aa)
PGUG_02228Coatomer_WDAD domain-containing protein. (283 aa)
PGUG_02274Small nuclear ribonucleoprotein Sm D2. (112 aa)
PGUG_02275Uncharacterized protein. (770 aa)
PGUG_02319WD_REPEATS_REGION domain-containing protein. (487 aa)
PGUG_02328Uncharacterized protein. (208 aa)
PGUG_02442Cleavage and polyadenylation specificity factor subunit 2. (821 aa)
PGUG_02443CCHC-type domain-containing protein. (482 aa)
PGUG_02446Uncharacterized protein. (701 aa)
PGUG_02490Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (331 aa)
PGUG_02573Uncharacterized protein. (374 aa)
PGUG_02678Uncharacterized protein. (516 aa)
PGUG_02741Uncharacterized protein; Belongs to the RNR ribonuclease family. (978 aa)
PGUG_02767MFAP1 domain-containing protein. (168 aa)
PGUG_02772WD_REPEATS_REGION domain-containing protein. (499 aa)
PGUG_02801J domain-containing protein. (287 aa)
PGUG_02806mRNA_triPase domain-containing protein. (460 aa)
PGUG_02815Cir_N domain-containing protein. (200 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (97 aa)
PGUG_02887PSP domain-containing protein. (455 aa)
PGUG_02919Uncharacterized protein. (476 aa)
PGUG_02935Small nuclear ribonucleoprotein E; Associated with the spliceosome snRNP U1, U2, U4/U6 and U5. Belongs to the snRNP Sm proteins family. (84 aa)
PGUG_02962G-patch_2 domain-containing protein. (220 aa)
PGUG_03049Transcription elongation factor SPT4; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (112 aa)
PGUG_03097WD_REPEATS_REGION domain-containing protein. (362 aa)
PGUG_03117Uncharacterized protein. (1170 aa)
DHH1ATP-dependent RNA helicase DHH1; ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity); Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (547 aa)
PGUG_03159PWI domain-containing protein. (529 aa)
PGUG_03160Uncharacterized protein. (696 aa)
PGUG_03205tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA- splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (372 aa)
PGUG_03223Uncharacterized protein. (226 aa)
PGUG_03238Uncharacterized protein. (605 aa)
PGUG_03321Matrin-type domain-containing protein. (226 aa)
PGUG_03324Uncharacterized protein. (388 aa)
PGUG_03332Small nuclear ribonucleoprotein Sm D3. (106 aa)
PGUG_03372Uncharacterized protein. (752 aa)
PGUG_03382Uncharacterized protein. (706 aa)
PGUG_03399Uncharacterized protein. (500 aa)
PGUG_03402Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (554 aa)
PGUG_03407Uncharacterized protein. (578 aa)
PGUG_03483Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
PGUG_03510Uncharacterized protein. (386 aa)
PGUG_03557MI domain-containing protein. (621 aa)
PGUG_03565WD_REPEATS_REGION domain-containing protein. (466 aa)
CLP1mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (492 aa)
PGUG_03598RRM domain-containing protein. (110 aa)
PGUG_03610Uncharacterized protein. (155 aa)
PGUG_03660CID domain-containing protein. (427 aa)
PGUG_03766Ubiquitin-like domain-containing protein. (73 aa)
PGUG_03795Uncharacterized protein. (246 aa)
PGUG_03992Uncharacterized protein. (113 aa)
PGUG_04120Sm domain-containing protein. (122 aa)
PGUG_04128Nop domain-containing protein. (474 aa)
PGUG_04132Uncharacterized protein. (491 aa)
PGUG_04180DUF3453 domain-containing protein. (684 aa)
PGUG_04247Uncharacterized protein. (307 aa)
PGUG_04251Uncharacterized protein. (1243 aa)
PAB1Polyadenylate-binding protein, cytoplasmic and nuclear; Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and [...] (631 aa)
PGUG_04336Uncharacterized protein. (1426 aa)
PGUG_04337Uncharacterized protein. (174 aa)
PGUG_00392Uncharacterized protein. (304 aa)
PGUG_00340Sm domain-containing protein. (195 aa)
YME2Mitochondrial escape protein 2; Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity); Belongs to the YME2 family. (874 aa)
PGUG_00282Uncharacterized protein. (445 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1098 aa)
PGUG_00185RRM domain-containing protein. (359 aa)
CCM1Mitochondrial group I intron splicing factor CCM1; RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity); Belongs to the CCM1 family. (644 aa)
PGUG_00149Uncharacterized protein. (301 aa)
PGUG_00146Uncharacterized protein. (422 aa)
PGUG_00108WD_REPEATS_REGION domain-containing protein. (465 aa)
PGUG_00096Uncharacterized protein. (636 aa)
PGUG_00095JAB_MPN domain-containing protein. (1743 aa)
PGUG_00058Uncharacterized protein. (1065 aa)
PGUG_05766SKIP_SNW domain-containing protein. (309 aa)
PGUG_05728Sm domain-containing protein. (121 aa)
PGUG_05624Uncharacterized protein. (259 aa)
PGUG_05527RRM domain-containing protein. (196 aa)
PGUG_05494DBR1 domain-containing protein. (392 aa)
PGUG_05462Uncharacterized protein. (815 aa)
PGUG_05446Uncharacterized protein. (1084 aa)
PGUG_05370BRAP2 domain-containing protein. (351 aa)
PGUG_05356Uncharacterized protein. (1460 aa)
PGUG_05276Uncharacterized protein. (266 aa)
PGUG_05272Suf domain-containing protein. (725 aa)
PGUG_05250Uncharacterized protein. (306 aa)
PGUG_05130Nuclear cap-binding protein subunit 2. (198 aa)
PGUG_05007TPR_REGION domain-containing protein. (874 aa)
PGUG_04943Transcription elongation factor SPT5; The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. (963 aa)
PGUG_04846Uncharacterized protein. (509 aa)
PGUG_04785Cell division control protein 28. (307 aa)
PGUG_04751G-patch domain-containing protein. (672 aa)
PGUG_04749CDC73_C domain-containing protein. (373 aa)
LOT5Protein LOT5. (254 aa)
PGUG_04580CPSF_A domain-containing protein. (1320 aa)
PGUG_04457RNase_PH domain-containing protein. (325 aa)
PGUG_04444Uncharacterized protein. (443 aa)
PGUG_05902Uncharacterized protein. (445 aa)
PGUG_05818Uncharacterized protein. (183 aa)
PGUG_00402Plus3 domain-containing protein. (539 aa)
PGUG_05772PseudoU_synth_1 domain-containing protein. (477 aa)
PGUG_00426G-patch domain-containing protein. (246 aa)
Your Current Organism:
Meyerozyma guilliermondii
NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260
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