(81 nodes) Ubiquitin-like protein transferase activity network (Meyerozyma guilliermondii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PGUG_03024	Uncharacterized protein. (270 aa)
	PGUG_02920	HECT domain-containing protein. (3274 aa)
	PGUG_02879	Ubiquitin-conjugating enzyme E2 4; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	PGUG_02867	RING-type domain-containing protein. (796 aa)
	PGUG_02863	Uncharacterized protein. (807 aa)
	PGUG_02605	Uncharacterized protein. (572 aa)
	PGUG_02574	Uncharacterized protein. (725 aa)
	PGUG_02554	RBR-type E3 ubiquitin transferase. (534 aa)
	PGUG_04097	RING-type domain-containing protein. (553 aa)
	PGUG_04170	U-box domain-containing protein. (197 aa)
	ATG5	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...] (258 aa)
	PGUG_01115	RING-type domain-containing protein. (136 aa)
	PGUG_01039	RING-type domain-containing protein. (407 aa)
	PGUG_01000	Uncharacterized protein. (374 aa)
	PGUG_00931	RING-type domain-containing protein. (362 aa)
	PGUG_00773	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
	PGUG_00870	HECT domain-containing protein. (868 aa)
	PGUG_00892	Uncharacterized protein. (378 aa)
	PGUG_00900	RING-type domain-containing protein. (502 aa)
	PGUG_04194	RING-type domain-containing protein. (597 aa)
	PGUG_04414	Rad60-SLD domain-containing protein. (398 aa)
	PGUG_04561	RING-type domain-containing protein. (470 aa)
	PGUG_04566	MAGE domain-containing protein. (324 aa)
	PGUG_04611	Uncharacterized protein. (168 aa)
	PGUG_04640	Autophagy_act_C domain-containing protein. (159 aa)
	PGUG_00347	UBR-type domain-containing protein. (456 aa)
	PGUG_00450	Helicase ATP-binding domain-containing protein. (691 aa)
	PGUG_00451	Uncharacterized protein. (1002 aa)
	PGUG_00521	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (439 aa)
	PGUG_00590	C3H1-type domain-containing protein. (287 aa)
	PGUG_04643	WLM domain-containing protein. (266 aa)
	ATG3	Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of [...] (293 aa)
	PGUG_04730	Uncharacterized protein. (1569 aa)
	PGUG_04800	CLTH domain-containing protein. (557 aa)
	PGUG_04836	UBIQUITIN_CONJUGAT_2 domain-containing protein. (155 aa)
	PGUG_04932	RING-type domain-containing protein. (446 aa)
	PGUG_04942	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (488 aa)
	PGUG_05009	UBIQUITIN_CONJUGAT_2 domain-containing protein. (100 aa)
	PGUG_05073	HECT domain-containing protein. (1627 aa)
	PGUG_05103	RING-type domain-containing protein. (145 aa)
	PGUG_05250	Uncharacterized protein. (306 aa)
	PGUG_05283	Uncharacterized protein. (561 aa)
	PGUG_05503	Uncharacterized protein. (321 aa)
	PGUG_05567	RING-type domain-containing protein. (536 aa)
	PGUG_05641	Ubiquitin-conjugating enzyme E2 2; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
	PGUG_05697	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
	PGUG_05826	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (240 aa)
	PGUG_04018	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (221 aa)
	PGUG_02423	Uncharacterized protein. (466 aa)
	PGUG_02501	Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (306 aa)
	PGUG_02508	HECT domain-containing protein. (974 aa)
	PGUG_00344	RING-type domain-containing protein. (370 aa)
	PGUG_00314	Uncharacterized protein. (659 aa)
	PGUG_00304	Uncharacterized protein. (587 aa)
	PGUG_00199	U-box domain-containing protein. (289 aa)
	PGUG_00097	Uncharacterized protein. (701 aa)
	PGUG_02394	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (674 aa)
	PGUG_02393	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1064 aa)
	PGUG_02392	E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (1935 aa)
	PGUG_02380	U-box domain-containing protein. (1017 aa)
	PGUG_02262	Uncharacterized protein. (572 aa)
	PGUG_02228	Coatomer_WDAD domain-containing protein. (283 aa)
	PGUG_02180	E3 ubiquitin protein ligase. (649 aa)
	PGUG_02152	RBR-type E3 ubiquitin transferase. (472 aa)
	PGUG_02010	Uncharacterized protein. (385 aa)
	PGUG_02008	UBIQUITIN_CONJUGAT_2 domain-containing protein. (277 aa)
	PGUG_01993	CLTH domain-containing protein. (489 aa)
	PGUG_01945	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
	PGUG_01924	RING-type domain-containing protein. (523 aa)
	PGUG_01644	Uncharacterized protein. (525 aa)
	PGUG_01594	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
	PGUG_01556	E3 ubiquitin-protein ligase. (773 aa)
	PGUG_01539	Uncharacterized protein. (1397 aa)
	PGUG_01510	RING-type domain-containing protein. (241 aa)
	PGUG_01331	Uncharacterized protein. (355 aa)
	PGUG_01258	Uncharacterized protein. (457 aa)
	PGUG_01244	RING-type domain-containing protein. (1616 aa)
	PGUG_03889	SP-RING-type domain-containing protein. (291 aa)
	PGUG_03783	Uncharacterized protein. (809 aa)
	PGUG_03782	RING-type domain-containing protein. (274 aa)
	PGUG_03161	Uncharacterized protein. (579 aa)

Your Current Organism:

Meyerozyma guilliermondii

NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG3	ATG5	A5DN42	A5DCZ3	Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of [...]	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...]	0.999
ATG5	ATG3	A5DCZ3	A5DN42	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1- like activating enzyme and ATG10 as an E2- [...]	Autophagy-related protein 3; E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C- terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of [...]	0.999
PGUG_00199	PGUG_00521	A5DA94	A5DB66	U-box domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.690
PGUG_00199	PGUG_02380	A5DA94	A5DGH9	U-box domain-containing protein.	U-box domain-containing protein.	0.414
PGUG_00199	PGUG_02879	A5DA94	A5DHX8	U-box domain-containing protein.	Ubiquitin-conjugating enzyme E2 4; Belongs to the ubiquitin-conjugating enzyme family.	0.690
PGUG_00199	PGUG_04170	A5DA94	A5DLL9	U-box domain-containing protein.	U-box domain-containing protein.	0.914
PGUG_00199	PGUG_04836	A5DA94	A5DNI5	U-box domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.447
PGUG_00199	PGUG_05641	A5DA94	A5DQU0	U-box domain-containing protein.	Ubiquitin-conjugating enzyme E2 2; Belongs to the ubiquitin-conjugating enzyme family.	0.412
PGUG_00199	PGUG_05697	A5DA94	A5DQZ6	U-box domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.880
PGUG_00304	PGUG_00521	A5DAJ9	A5DB66	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.679
PGUG_00304	PGUG_01244	A5DAJ9	A5DD93	Uncharacterized protein.	RING-type domain-containing protein.	0.565
PGUG_00304	PGUG_02879	A5DAJ9	A5DHX8	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 4; Belongs to the ubiquitin-conjugating enzyme family.	0.827
PGUG_00304	PGUG_04018	A5DAJ9	A5DL67	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.604
PGUG_00304	PGUG_04194	A5DAJ9	A5DLP3	Uncharacterized protein.	RING-type domain-containing protein.	0.426
PGUG_00304	PGUG_05073	A5DAJ9	A5DP72	Uncharacterized protein.	HECT domain-containing protein.	0.449
PGUG_00304	PGUG_05697	A5DAJ9	A5DQZ6	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.679
PGUG_00314	PGUG_00521	A5DAK9	A5DB66	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.640
PGUG_00314	PGUG_01115	A5DAK9	A5DCW0	Uncharacterized protein.	RING-type domain-containing protein.	0.999
PGUG_00314	PGUG_02879	A5DAK9	A5DHX8	Uncharacterized protein.	Ubiquitin-conjugating enzyme E2 4; Belongs to the ubiquitin-conjugating enzyme family.	0.640
PGUG_00314	PGUG_04018	A5DAK9	A5DL67	Uncharacterized protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.435