STRINGSTRING
PGUG_04038 PGUG_04038 PGUG_01095 PGUG_01095 PGUG_01133 PGUG_01133 PGUG_01317 PGUG_01317 PGUG_01351 PGUG_01351 PGUG_01384 PGUG_01384 PGUG_01405 PGUG_01405 PGUG_01452 PGUG_01452 PGUG_01486 PGUG_01486 PGUG_01552 PGUG_01552 AAH1 AAH1 PGUG_01621 PGUG_01621 PGUG_01630 PGUG_01630 PGUG_01875 PGUG_01875 PGUG_01980 PGUG_01980 PGUG_05725 PGUG_05725 POA1 POA1 PGUG_05561 PGUG_05561 PGUG_05499 PGUG_05499 PGUG_05405 PGUG_05405 PGUG_05320 PGUG_05320 PGUG_05240 PGUG_05240 PGUG_05231 PGUG_05231 PGUG_05089 PGUG_05089 PGUG_05084 PGUG_05084 PGUG_05054 PGUG_05054 PGUG_05035 PGUG_05035 PGUG_05024 PGUG_05024 PGUG_04946 PGUG_04946 PGUG_04939 PGUG_04939 PGUG_04813 PGUG_04813 PGUG_04712 PGUG_04712 PGUG_04679 PGUG_04679 PGUG_04596 PGUG_04596 PGUG_04523 PGUG_04523 PGUG_04428 PGUG_04428 PGUG_04391 PGUG_04391 PGUG_04377 PGUG_04377 PGUG_04358 PGUG_04358 PGUG_04335 PGUG_04335 ADK2 ADK2 PGUG_04243 PGUG_04243 PGUG_04215 PGUG_04215 PGUG_04085 PGUG_04085 PGUG_04080 PGUG_04080 PGUG_04041 PGUG_04041 PGUG_00980 PGUG_00980 PGUG_04001 PGUG_04001 PGUG_03927 PGUG_03927 PGUG_03911 PGUG_03911 PGUG_03817 PGUG_03817 PGUG_03808 PGUG_03808 PGUG_02092 PGUG_02092 PGUG_02086 PGUG_02086 PGUG_02000 PGUG_02000 PGUG_03763 PGUG_03763 PGUG_03762 PGUG_03762 PGUG_03731 PGUG_03731 PGUG_03665 PGUG_03665 PGUG_03664 PGUG_03664 MEU1 MEU1 PGUG_03555 PGUG_03555 PGUG_03513 PGUG_03513 PGUG_03476 PGUG_03476 PGUG_03248 PGUG_03248 PGUG_03227 PGUG_03227 PGUG_03184 PGUG_03184 PGUG_03172 PGUG_03172 PGUG_03145 PGUG_03145 PGUG_03140 PGUG_03140 PGUG_03123 PGUG_03123 PGUG_03092 PGUG_03092 PGUG_03057 PGUG_03057 PGUG_03026 PGUG_03026 PGUG_02996 PGUG_02996 PGUG_02911 PGUG_02911 PGUG_02895 PGUG_02895 PGUG_02836 PGUG_02836 PGUG_02787 PGUG_02787 PGUG_02752 PGUG_02752 PGUG_02738 PGUG_02738 PGUG_02674 PGUG_02674 PGUG_02610 PGUG_02610 PGUG_02601 PGUG_02601 PGUG_02484 PGUG_02484 PGUG_02477 PGUG_02477 PGUG_02404 PGUG_02404 PGUG_02402 PGUG_02402 PGUG_02305 PGUG_02305 PGUG_02272 PGUG_02272 PGUG_02229 PGUG_02229 PGUG_02101 PGUG_02101 PGUG_00141 PGUG_00141 PGUG_00150 PGUG_00150 PGUG_00164 PGUG_00164 PGUG_00316 PGUG_00316 PGUG_00480 PGUG_00480 PGUG_00564 PGUG_00564 PGUG_00565 PGUG_00565 PGUG_00596 PGUG_00596 PGUG_00716 PGUG_00716 PGUG_00752 PGUG_00752 PGUG_00805 PGUG_00805 ADK1 ADK1 PGUG_00918 PGUG_00918 PGUG_00926 PGUG_00926 PGUG_00939 PGUG_00939 PGUG_00965 PGUG_00965 PGUG_00977 PGUG_00977
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PGUG_04038Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (423 aa)
PGUG_01095Diphosphomevalonate decarboxylase. (297 aa)
PGUG_01133ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (447 aa)
PGUG_01317Glyceraldehyde-3-phosphate dehydrogenase. (335 aa)
PGUG_01351Pribosyltran domain-containing protein. (203 aa)
PGUG_01384ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (489 aa)
PGUG_01405Triosephosphate isomerase. (248 aa)
PGUG_01452Uncharacterized protein. (286 aa)
PGUG_01486Gluconokinase; Belongs to the gluconokinase GntK/GntV family. (186 aa)
PGUG_01552TR_THY domain-containing protein. (162 aa)
AAH1Adenine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. (357 aa)
PGUG_01621Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa)
PGUG_01630Enolase_N domain-containing protein. (186 aa)
PGUG_01875Glutamine amidotransferase type-1 domain-containing protein. (1336 aa)
PGUG_01980Uncharacterized protein. (2203 aa)
PGUG_05725ATP-synt_DE_N domain-containing protein. (161 aa)
POA1ADP-ribose 1''-phosphate phosphatase; Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing; Belongs to the POA1 family. (175 aa)
PGUG_05561Acetyl-coenzyme A synthetase. (670 aa)
PGUG_05499Nudix hydrolase domain-containing protein. (356 aa)
PGUG_05405Carn_acyltransf domain-containing protein. (843 aa)
PGUG_05320Uncharacterized protein. (649 aa)
PGUG_05240Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (291 aa)
PGUG_05231Carn_acyltransf domain-containing protein; Belongs to the carnitine/choline acetyltransferase family. (622 aa)
PGUG_05089Uncharacterized protein. (429 aa)
PGUG_050846-phosphogluconate dehydrogenase, decarboxylating; Belongs to the 6-phosphogluconate dehydrogenase family. (409 aa)
PGUG_05054Uncharacterized protein. (151 aa)
PGUG_05035A_deaminase domain-containing protein. (819 aa)
PGUG_05024Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (287 aa)
PGUG_04946Pribosyltran domain-containing protein. (186 aa)
PGUG_04939TauD domain-containing protein. (394 aa)
PGUG_04813Acetyl-coenzyme A synthetase. (514 aa)
PGUG_047123-hydroxy-3-methylglutaryl coenzyme A reductase. (1024 aa)
PGUG_04679ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (952 aa)
PGUG_04596Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
PGUG_04523Uncharacterized protein. (206 aa)
PGUG_04428Cell division control protein 48; Belongs to the AAA ATPase family. (825 aa)
PGUG_04391Enolase 1. (439 aa)
PGUG_04377Phosphoribosylaminoimidazole carboxylase; In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. (568 aa)
PGUG_04358Uncharacterized protein. (236 aa)
PGUG_04335Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (396 aa)
ADK2GTP:AMP phosphotransferase, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (230 aa)
PGUG_042433-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (442 aa)
PGUG_04215Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (521 aa)
PGUG_04085Uncharacterized protein. (944 aa)
PGUG_04080Succinate-CoA ligase subunit beta. (327 aa)
PGUG_04041GMP synthase. (529 aa)
PGUG_009803',5'-cyclic-nucleotide phosphodiesterase. (381 aa)
PGUG_04001Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (521 aa)
PGUG_03927ADSL_C domain-containing protein. (449 aa)
PGUG_03911Uncharacterized protein. (1475 aa)
PGUG_03817Bifunctional purine biosynthesis protein ADE17. (590 aa)
PGUG_03808Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (416 aa)
PGUG_02092Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (301 aa)
PGUG_02086Uncharacterized protein. (94 aa)
PGUG_02000Uncharacterized protein. (340 aa)
PGUG_03763Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (407 aa)
PGUG_03762Uncharacterized protein. (507 aa)
PGUG_03731Pribosyltran_N domain-containing protein. (472 aa)
PGUG_03665Uncharacterized protein. (358 aa)
PGUG_03664Uncharacterized protein. (345 aa)
MEU1S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (348 aa)
PGUG_03555CTP_transf_like domain-containing protein. (294 aa)
PGUG_03513Uncharacterized protein. (351 aa)
PGUG_03476Lipoyl-binding domain-containing protein. (446 aa)
PGUG_03248Flavoprotein domain-containing protein. (454 aa)
PGUG_03227Uncharacterized protein. (150 aa)
PGUG_03184Uncharacterized protein. (322 aa)
PGUG_03172Uncharacterized protein. (466 aa)
PGUG_03145Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). Belongs to the adenylosuccinate synthetase family. (426 aa)
PGUG_03140Amidophosphoribosyltransferase. (530 aa)
PGUG_03123ATP-grasp domain-containing protein. (814 aa)
PGUG_03092ATP synthase subunit d, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the cent [...] (175 aa)
PGUG_03057Adenosylhomocysteinase. (449 aa)
PGUG_03026ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (984 aa)
PGUG_02996Pribosyltran domain-containing protein. (213 aa)
PGUG_02911Formyl_trans_N domain-containing protein. (210 aa)
PGUG_02895AMP-binding domain-containing protein. (608 aa)
PGUG_02836IMP-specific 5'-nucleotidase 1; IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation. (478 aa)
PGUG_02787Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (404 aa)
PGUG_02752Uncharacterized protein. (66 aa)
PGUG_02738Flavoprotein domain-containing protein. (411 aa)
PGUG_02674Guanylate kinase-like domain-containing protein. (186 aa)
PGUG_02610Uncharacterized protein. (205 aa)
PGUG_02601Phosphotransferase. (469 aa)
PGUG_02484Homeobox domain-containing protein. (436 aa)
PGUG_02477Ribose-phosphate pyrophosphokinase 1. (320 aa)
PGUG_02404GHMP_kinases_C domain-containing protein. (277 aa)
PGUG_02402GHMP_kinases_N domain-containing protein. (247 aa)
PGUG_02305SAICAR_synt domain-containing protein. (298 aa)
PGUG_02272Aminotran_5 domain-containing protein. (296 aa)
PGUG_02229Uncharacterized protein. (608 aa)
PGUG_02101Uncharacterized protein. (767 aa)
PGUG_00141Uncharacterized protein. (572 aa)
PGUG_00150Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (474 aa)
PGUG_00164Amidohydro-rel domain-containing protein. (490 aa)
PGUG_00316ATP synthase subunit gamma. (261 aa)
PGUG_00480Phosphotransferase. (536 aa)
PGUG_00564OHCU_decarbox domain-containing protein. (184 aa)
PGUG_00565Vacuolar ATP synthase catalytic subunit A. (612 aa)
PGUG_00596Flavoprotein domain-containing protein. (491 aa)
PGUG_00716Pyruvate kinase; Belongs to the pyruvate kinase family. (504 aa)
PGUG_00752PfkB domain-containing protein. (347 aa)
PGUG_00805Uncharacterized protein. (2297 aa)
ADK1Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. (247 aa)
PGUG_00918Nucleoside diphosphate kinase. (151 aa)
PGUG_00926Glucose-6-phosphate isomerase; Belongs to the GPI family. (551 aa)
PGUG_00939Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa)
PGUG_00965Phosphotransferase. (481 aa)
PGUG_00977Nudix hydrolase domain-containing protein. (199 aa)
Your Current Organism:
Meyerozyma guilliermondii
NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260
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