(30 nodes) Papain-like cysteine peptidase superfamily network (Meyerozyma guilliermondii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PGUG_01339	Uncharacterized protein. (964 aa)
	PGUG_01652	Ubiquitin carboxyl-terminal hydrolase. (726 aa)
	ATG4	Probable cysteine protease ATG4; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C- terminus for its conjugation t [...] (402 aa)
	PGUG_01817	ULP_PROTEASE domain-containing protein. (263 aa)
	PGUG_01995	Ubiquitin carboxyl-terminal hydrolase. (585 aa)
	PGUG_02717	Ubiquitin carboxyl-terminal hydrolase. (801 aa)
	PGUG_02732	Ubiquitin carboxyl-terminal hydrolase. (484 aa)
	PGUG_02773	USP domain-containing protein. (786 aa)
	PGUG_03014	Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (647 aa)
	PGUG_03064	Ubiquitin carboxyl-terminal hydrolase. (312 aa)
	PGUG_03374	OTU domain-containing protein. (285 aa)
	PGUG_03537	TGc domain-containing protein. (354 aa)
	PGUG_03554	Uncharacterized protein; Belongs to the peptidase C19 family. (1280 aa)
	PGUG_03560	Ubiquitin carboxyl-terminal hydrolase. (516 aa)
	PGUG_04443	Ubiquitin carboxyl-terminal hydrolase. (238 aa)
	PGUG_04456	Uncharacterized protein; Belongs to the peptidase C19 family. (1169 aa)
	PGUG_04545	Uncharacterized protein. (658 aa)
	PGUG_04777	USP domain-containing protein; Belongs to the peptidase C19 family. (1205 aa)
	PGUG_04851	USP domain-containing protein; Belongs to the peptidase C19 family. (589 aa)
	PGUG_05202	Ubiquitin carboxyl-terminal hydrolase. (687 aa)
	PGUG_05330	ULP_PROTEASE domain-containing protein. (778 aa)
	PGUG_05588	USP domain-containing protein. (365 aa)
	PGUG_05587	UCH domain-containing protein. (173 aa)
	PGUG_00140	Ubiquitin carboxyl-terminal hydrolase. (788 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1098 aa)
	PGUG_00285	ULP_PROTEASE domain-containing protein. (464 aa)
	PGUG_00492	Ubiquitin carboxyl-terminal hydrolase. (879 aa)
	PGUG_01006	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. (454 aa)
	PGUG_01060	Uncharacterized protein. (487 aa)
	PGUG_01170	OTU domain-containing protein. (343 aa)

Your Current Organism:

Meyerozyma guilliermondii

NCBI taxonomy Id: 294746
Other names: M. guilliermondii ATCC 6260, Meyerozyma guilliermondii ATCC 6260, Pichia guilliermondii ATCC 6260

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PAN2	PGUG_01060	A5DAD0	A5DCQ5	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...]	Uncharacterized protein.	0.426
PGUG_00140	PGUG_05202	A5DA35	A5DPK1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.429
PGUG_00285	PGUG_01817	A5DAI0	A5DEW6	ULP_PROTEASE domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.720
PGUG_00285	PGUG_05330	A5DAI0	A5DPX9	ULP_PROTEASE domain-containing protein.	ULP_PROTEASE domain-containing protein.	0.907
PGUG_00492	PGUG_01170	A5DB37	A5DD15	Ubiquitin carboxyl-terminal hydrolase.	OTU domain-containing protein.	0.495
PGUG_00492	PGUG_02717	A5DB37	A5DHG6	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.535
PGUG_00492	PGUG_02732	A5DB37	A5DHI1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.545
PGUG_00492	PGUG_03374	A5DB37	A5DJC3	Ubiquitin carboxyl-terminal hydrolase.	OTU domain-containing protein.	0.424
PGUG_00492	PGUG_03554	A5DB37	A5DJV3	Ubiquitin carboxyl-terminal hydrolase.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.562
PGUG_00492	PGUG_04777	A5DB37	A5DNC6	Ubiquitin carboxyl-terminal hydrolase.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.599
PGUG_00492	PGUG_05202	A5DB37	A5DPK1	Ubiquitin carboxyl-terminal hydrolase.	Ubiquitin carboxyl-terminal hydrolase.	0.435
PGUG_01060	PAN2	A5DCQ5	A5DAD0	Uncharacterized protein.	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...]	0.426
PGUG_01060	PGUG_02717	A5DCQ5	A5DHG6	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.549
PGUG_01060	PGUG_02732	A5DCQ5	A5DHI1	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.490
PGUG_01060	PGUG_03554	A5DCQ5	A5DJV3	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C19 family.	0.485
PGUG_01060	PGUG_05202	A5DCQ5	A5DPK1	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase.	0.464
PGUG_01170	PGUG_00492	A5DD15	A5DB37	OTU domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.495
PGUG_01170	PGUG_01652	A5DD15	A5DEF1	OTU domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.472
PGUG_01170	PGUG_02717	A5DD15	A5DHG6	OTU domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.544
PGUG_01170	PGUG_02732	A5DD15	A5DHI1	OTU domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.509