(116 nodes) Negative regulation of nitrogen compound metabolic process network (Cryptococcus gattii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CNBG_4813	RNA binding protein. (684 aa)
	CNBG_6068	Uncharacterized protein. (236 aa)
	CNBG_5172	SWR1-complex protein 4. (463 aa)
	CNBG_5187	CBFD_NFYB_HMF domain-containing protein. (274 aa)
	CNBG_5985	RNase_PH domain-containing protein. (299 aa)
	CNBG_6193	Serine-threonine kinase receptor-associated protein. (350 aa)
	CNBG_6213	CAMK protein kinase. (684 aa)
	CNBG_5467	Pumilio 2. (626 aa)
	CNBG_0134	Chromo domain-containing protein. (519 aa)
	CNBG_0374	Ubiquitin carboxyl-terminal hydrolase 1. (713 aa)
	CNBG_0709	Exosome complex component RRP40. (247 aa)
	CNBG_1544	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (565 aa)
	CNBG_1664	MAGE domain-containing protein. (508 aa)
	CNBG_1719	Translation elongation factor Tu. (754 aa)
	CNBG_3034	Signal transducer. (929 aa)
	CNBG_3464	Pumilio-family RNA binding protein. (954 aa)
	CNBG_3579	CCR4-NOT transcription complex subunit 1. (2265 aa)
	CNBG_3993	Uncharacterized protein. (215 aa)
	CNBG_3873	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (734 aa)
	CNBG_4749	Asparaginase. (387 aa)
	CNBG_5004	Uncharacterized protein. (135 aa)
	CNBG_5679	Uncharacterized protein. (553 aa)
	CNBG_5709	Uncharacterized protein. (321 aa)
	CNBG_5999	DNA repair protein RAD5. (1359 aa)
	CNBG_0771	CBFD_NFYB_HMF domain-containing protein. (136 aa)
	CNBG_0901	WD-repeat protein. (558 aa)
	CNBG_0911	Co-chaperone. (522 aa)
	CNBG_1246	CMGC/CLK protein kinase; Belongs to the protein kinase superfamily. (403 aa)
	CNBG_1346	cAMP-dependent protein kinase regulatory subunit. (482 aa)
	CNBG_1746	Signal recognition particle subunit SRP9. (142 aa)
	CNBG_1836	ESCRT-II complex subunit VPS22. (275 aa)
	CNBG_2046	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (947 aa)
	CNBG_0013	Uncharacterized protein. (455 aa)
	CNBG_0078	Pumilio domain-containing protein. (678 aa)
	CNBG_0233	Uncharacterized protein. (371 aa)
	CNBG_0283	Uncharacterized protein. (543 aa)
	CNBG_0200	Uncharacterized protein. (170 aa)
	CNBG_0465	Exosome complex component RRP4. (331 aa)
	CNBG_0978	Histone deacetylase complex subunit. (309 aa)
	CNBG_1045	Chromosome segregation in meiosis protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (394 aa)
	CNBG_1090	Exosome complex component RRP43. (321 aa)
	CNBG_0447	Two-component system sensor protein. (1208 aa)
	CNBG_1265	DNA topoisomerase 2-associated protein PAT1. (838 aa)
	CNBG_2151	Uncharacterized protein. (194 aa)
	CNBG_1528	Ribosomal protein L13. (163 aa)
	CNBG_0517	Uncharacterized protein. (483 aa)
	CNBG_1733	RNase_PH domain-containing protein. (332 aa)
	CNBG_1535	Cell growth-regulating nucleolar protein. (310 aa)
	CNBG_1610	Topoisomerase 1-associated factor 1. (1075 aa)
	CNBG_1853	Uncharacterized protein. (488 aa)
	CNBG_1695	Ubiquitin-conjugating enzyme E2 O. (924 aa)
	CNBG_0917	Uncharacterized protein. (696 aa)
	CNBG_2003	Nucleoporin family protein. (2068 aa)
	CNBG_0937	Uncharacterized protein. (520 aa)
	CNBG_1880	Nefa_Nip30_N domain-containing protein. (239 aa)
	CNBG_06215	Uncharacterized protein. (100 aa)
	CNBG_9105	UV excision repair protein Rad23. (384 aa)
	CNBG_9192	Uncharacterized protein. (124 aa)
	CNBG_9025	Uncharacterized protein. (1182 aa)
	CNBG_9614	Iron regulator 1. (1154 aa)
	CNBG_9451	Specific transcriptional repressor. (1045 aa)
	PAN3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exo [...] (670 aa)
	CNBG_5794	NAD-dependent histone deacetylase SIR2. (586 aa)
	CNBG_5891	WD_REPEATS_REGION domain-containing protein. (564 aa)
	CNBG_5851	DNA-directed RNA polymerase II subunit RPB4. (153 aa)
	CNBG_5301	Anaphase-promoting complex subunit 6. (640 aa)
	CNBG_5211	TATA-binding protein-associated factor. (1848 aa)
	CNBG_4646	Uncharacterized protein. (364 aa)
	CNBG_4396	Guanine nucleotide-binding protein subunit beta-like protein. (314 aa)
	CNBG_4336	Uncharacterized protein. (1251 aa)
	CNBG_3750	mRNA-decapping enzyme subunit 2. (822 aa)
	CNBG_4025	VPS37 C-terminal domain-containing protein. (199 aa)
	CNBG_3431	Exosome complex exonuclease RRP6. (954 aa)
	CNBG_3271	Nuclear protein localization protein 4. (701 aa)
	CNBG_3041	General transcriptional repressor. (1103 aa)
	CNBG_2876	Histone H1/5. (193 aa)
	CNBG_2671	NADH dehydrogenase (Ubiquinone) 1 alpha subcomplex 13. (123 aa)
	CNBG_2436	Structural maintenance of chromosomes protein. (1214 aa)
	CNBG_2286	YTH domain family 2. (777 aa)
	CNBG_1930	CCR4-NOT transcription complex subunit 3. (755 aa)
	CNBG_2120	SAP domain-containing protein. (553 aa)
	CNBG_2165	Uncharacterized protein. (140 aa)
	CNBG_2215	DNA supercoiling protein. (999 aa)
	CNBG_2473	Ubiquitin carboxyl-terminal hydrolase. (483 aa)
	CNBG_2395	Glucose-repressible alcohol dehydrogenase transcriptional effector. (745 aa)
	CNBG_2430	Uncharacterized protein. (211 aa)
	CNBG_2540	DNA-binding protein. (325 aa)
	CNBG_1747	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (1095 aa)
	CNBG_2665	Peptidyl-tRNA hydrolase. (204 aa)
	CNBG_3073	Mitochondrial division protein 1. (758 aa)
	CNBG_2147	Uncharacterized protein. (373 aa)
	CNBG_2920	WD_REPEATS_REGION domain-containing protein. (706 aa)
	CNBG_3238	Exosome complex component RRP45. (196 aa)
	CNBG_3258	Cell differentiation protein rcd1. (443 aa)
	CNBG_3350	Uncharacterized protein. (310 aa)
	CNBG_3568	Histone H1/5. (192 aa)
	CNBG_3613	Transcriptional repressor NF-X1. (1172 aa)
	CNBG_3027	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1210 aa)
	CNBG_3252	Translation initiation factor 5. (402 aa)
	CNBG_3899	ATP-dependent RNA helicase DHH1; Belongs to the DEAD box helicase family. (615 aa)
	CNBG_3622	Paired amphipathic helix protein Sin3a. (1425 aa)
	CNBG_4648	Ubiquitin-conjugating enzyme family protein. (870 aa)
	CNBG_4525	CCR4-NOT transcription complex subunit 7/8. (293 aa)
	CNBG_4056	Polycomb protein EED. (571 aa)
	CNBG_2176	Endo alpha-1,4 polygalactosaminidase. (304 aa)
	CNBG_4715	Ubiquitin fusion degradation protein 1. (483 aa)
	CNBG_5003	Uncharacterized protein. (790 aa)
	CNBG_3861	mRNA stability protein; Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. (191 aa)
	CNBG_4312	Uncharacterized protein. (1049 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation. (135 aa)
	CNBG_5690	ESCRT-II complex subunit VPS25. (213 aa)
	CNBG_4932	Ribosomal protein L13; Belongs to the universal ribosomal protein uL13 family. (199 aa)
	CNBG_5933	Serine/threonine-protein phosphatase. (313 aa)
	CNBG_5953	Thioredoxin-like_fold domain-containing protein. (210 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent [...] (1181 aa)
	CNBG_5097	Scavenger mRNA-decapping enzyme DcpS. (270 aa)

Your Current Organism:

Cryptococcus gattii

NCBI taxonomy Id: 294750
Other names: C. gattii VGII R265, Cryptococcus bacillisporus R265, Cryptococcus bacillisporus VGII R265, Cryptococcus deuterogattii R265, Cryptococcus gattii R265, Cryptococcus gattii VGII R265, Cryptococcus neoformans R265

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNBG_0078	CNBG_1535	A0A095BZN1	A0A095C551	Pumilio domain-containing protein.	Cell growth-regulating nucleolar protein.	0.548
CNBG_0078	CNBG_3350	A0A095BZN1	A0A095CAU5	Pumilio domain-containing protein.	Uncharacterized protein.	0.472
CNBG_0078	CNBG_3464	A0A095BZN1	A0A095D9G0	Pumilio domain-containing protein.	Pumilio-family RNA binding protein.	0.641
CNBG_0078	CNBG_3899	A0A095BZN1	A0A095CDG4	Pumilio domain-containing protein.	ATP-dependent RNA helicase DHH1; Belongs to the DEAD box helicase family.	0.401
CNBG_0078	CNBG_5467	A0A095BZN1	A0A095CJY2	Pumilio domain-containing protein.	Pumilio 2.	0.575
CNBG_0134	CNBG_3873	A0A095CY66	A0A095DBL5	Chromo domain-containing protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.452
CNBG_0134	CNBG_9451	A0A095CY66	A0A0L6DGN2	Chromo domain-containing protein.	Specific transcriptional repressor.	0.500
CNBG_0200	CNBG_5933	A0A095C0Y9	A0A095CIF4	Uncharacterized protein.	Serine/threonine-protein phosphatase.	0.606
CNBG_0233	CNBG_0901	A0A095C063	A0A095EC59	Uncharacterized protein.	WD-repeat protein.	0.749
CNBG_0233	CNBG_0917	A0A095C063	A0A095C5X0	Uncharacterized protein.	Uncharacterized protein.	0.749
CNBG_0233	CNBG_5891	A0A095C063	A0A095ET38	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.749
CNBG_0283	CNBG_2003	A0A095C0C0	A0A095C5Y5	Uncharacterized protein.	Nucleoporin family protein.	0.410
CNBG_0374	CNBG_0901	A0A095CYZ9	A0A095EC59	Ubiquitin carboxyl-terminal hydrolase 1.	WD-repeat protein.	0.756
CNBG_0374	CNBG_0917	A0A095CYZ9	A0A095C5X0	Ubiquitin carboxyl-terminal hydrolase 1.	Uncharacterized protein.	0.740
CNBG_0374	CNBG_2473	A0A095CYZ9	A0A095C7I3	Ubiquitin carboxyl-terminal hydrolase 1.	Ubiquitin carboxyl-terminal hydrolase.	0.467
CNBG_0374	CNBG_2665	A0A095CYZ9	A0A095C8K3	Ubiquitin carboxyl-terminal hydrolase 1.	Peptidyl-tRNA hydrolase.	0.688
CNBG_0374	CNBG_5891	A0A095CYZ9	A0A095ET38	Ubiquitin carboxyl-terminal hydrolase 1.	WD_REPEATS_REGION domain-containing protein.	0.740
CNBG_0374	CNBG_9105	A0A095CYZ9	A0A0L6DI18	Ubiquitin carboxyl-terminal hydrolase 1.	UV excision repair protein Rad23.	0.765
CNBG_0447	CNBG_3873	A0A095C4A5	A0A095DBL5	Two-component system sensor protein.	Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.	0.525
CNBG_0465	CNBG_0709	A0A095C1X2	A0A095D034	Exosome complex component RRP4.	Exosome complex component RRP40.	0.999

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