(43 nodes) Tryptophan metabolism network (Cryptococcus gattii)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	CNBG_4920	Amidase. (573 aa)
	CNBG_0548	Aromatic-L-amino-acid decarboxylase. (532 aa)
	CNBG_0002	2-oxoglutarate dehydrogenase E2 component (Dihydrolipoamide succinyltransferase). (454 aa)
	CNBG_0172	Uncharacterized protein. (473 aa)
	CNBG_1082	Endoribonuclease L-PSP. (139 aa)
	CNBG_2025	3-hydroxyacyl-CoA dehydrogenase. (282 aa)
	CNBG_1937	Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (330 aa)
	CNBG_2027	Flavin-containing monooxygenase. (634 aa)
	CNBG_2920	WD_REPEATS_REGION domain-containing protein. (706 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (506 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (453 aa)
	CNBG_4074	Amidase. (551 aa)
	CNBG_3397	Uncharacterized protein. (283 aa)
	CNBG_4473	3-hydroxyacyl-CoA dehydrogenase. (281 aa)
	CNBG_3517	Tryptophan 2,3-dioxygenase. (573 aa)
	CNBG_3562	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
	CNBG_4655	Amine oxidase. (492 aa)
	CNBG_5478	GTP-binding protein 1. (619 aa)
	CNBG_4577	Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (520 aa)
	BNA1	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. (176 aa)
	CNBG_4657	Amine oxidase. (531 aa)
	CNBG_4667	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (701 aa)
	CNBG_5786	Catalase. (499 aa)
	CNBG_5237	Uncharacterized protein. (474 aa)
	CNBG_5845	NAD binding dehydrogenase. (407 aa)
	CNBG_0649	Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family. (495 aa)
	CNBG_1724	Tryptophan aminotransferase. (444 aa)
	CNBG_2539	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (283 aa)
	CNBG_2744	3-hydroxyacyl-CoA dehydrogenase. (329 aa)
	CNBG_4304	Septum formation protein Maf. (238 aa)
	CNBG_4339	Arylformamidase. (433 aa)
	CNBG_0526	Kynurenine aminotransferase. (430 aa)
	CNBG_1196	Aldehyde dehydrogenase family 7 member A1; Belongs to the aldehyde dehydrogenase family. (568 aa)
	CNBG_1526	Aromatic amino acid aminotransferase I. (517 aa)
	CNBG_1546	Uncharacterized protein. (175 aa)
	CNBG_2321	Glutaryl-CoA dehydrogenase. (424 aa)
	CNBG_3396	Flavin-containing monooxygenase. (647 aa)
	CNBG_3985	Homoserine O-acetyltransferase. (456 aa)
	CNBG_4696	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. (714 aa)
	CNBG_4751	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (536 aa)
	CNBG_4986	Amidase. (556 aa)
	CNBG_5871	Dihydrolipoyl dehydrogenase. (511 aa)
	CNBG_9425	Cupin_2 domain-containing protein. (255 aa)

Your Current Organism:

Cryptococcus gattii

NCBI taxonomy Id: 294750
Other names: C. gattii VGII R265, Cryptococcus bacillisporus R265, Cryptococcus bacillisporus VGII R265, Cryptococcus deuterogattii R265, Cryptococcus gattii R265, Cryptococcus gattii VGII R265, Cryptococcus neoformans R265

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA1	BNA4	A0A095CHC0	A0A095CAN6	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.853
BNA1	BNA5	A0A095CHC0	A0A095CB77	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.971
BNA1	CNBG_3517	A0A095CHC0	A0A095CDW7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Tryptophan 2,3-dioxygenase.	0.645
BNA1	CNBG_4667	A0A095CHC0	A0A095CHE7	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	0.882
BNA1	CNBG_4696	A0A095CHC0	A0A095EPH0	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family.	0.789
BNA1	CNBG_5786	A0A095CHC0	A0A095CI54	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	Catalase.	0.882
BNA4	BNA1	A0A095CAN6	A0A095CHC0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.853
BNA4	BNA5	A0A095CAN6	A0A095CB77	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.990
BNA4	CNBG_0526	A0A095CAN6	A0A095EAX8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynurenine aminotransferase.	0.933
BNA4	CNBG_0649	A0A095CAN6	A0A095CZW6	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family.	0.423
BNA4	CNBG_1526	A0A095CAN6	A0A095EE23	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aromatic amino acid aminotransferase I.	0.638
BNA4	CNBG_1546	A0A095CAN6	A0A095EE44	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.638
BNA4	CNBG_1724	A0A095CAN6	A0A095D3G1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Tryptophan aminotransferase.	0.638
BNA4	CNBG_1937	A0A095CAN6	A0A095C8Z2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family.	0.423
BNA4	CNBG_3517	A0A095CAN6	A0A095CDW7	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Tryptophan 2,3-dioxygenase.	0.599
BNA4	CNBG_3985	A0A095CAN6	A0A095EL86	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Homoserine O-acetyltransferase.	0.423
BNA4	CNBG_4339	A0A095CAN6	A0A095DC84	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Arylformamidase.	0.414
BNA4	CNBG_4577	A0A095CAN6	A0A095CH62	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aldehyde dehydrogenase (NAD+); Belongs to the aldehyde dehydrogenase family.	0.423
BNA4	CNBG_9425	A0A095CAN6	A0A0L6DIB9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Cupin_2 domain-containing protein.	0.552
BNA5	BNA1	A0A095CB77	A0A095CHC0	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.	0.971

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