(32 nodes) Propanoate metabolism network (Cryptococcus gattii)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	CNBG_0175	SET domain-containing protein. (497 aa)
	CNBG_1398	Uncharacterized protein. (200 aa)
	CNBG_1185	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (418 aa)
	CNBG_1428	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (628 aa)
	CNBG_0647	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (491 aa)
	CNBG_1137	Acetyl-coenzyme A synthetase. (680 aa)
	CNBG_1822	Uncharacterized protein. (557 aa)
	CNBG_2052	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (702 aa)
	CNBG_3193	Thioredoxin reductase GliT. (345 aa)
	CNBG_2602	Uncharacterized protein. (732 aa)
	CNBG_3997	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (490 aa)
	CNBG_4187	Methionyl-tRNA formyltransferase; Belongs to the enoyl-CoA hydratase/isomerase family. (939 aa)
	CNBG_3437	Cytoplasmic protein. (455 aa)
	CNBG_3562	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (406 aa)
	CNBG_5028	Probable acetate kinase. (430 aa)
	CNBG_4875	Uncharacterized protein. (441 aa)
	CNBG_5325	Dihydrokaempferol 4-reductase. (346 aa)
	CNBG_4612	Uncharacterized protein. (996 aa)
	CNBG_2539	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family. (283 aa)
	CNBG_2699	Methylmalonate-semialdehyde dehydrogenase (Acylating). (545 aa)
	CNBG_0261	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (444 aa)
	CNBG_0646	Methylmalonate-semialdehyde dehydrogenase (Acylating). (531 aa)
	CNBG_2231	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (333 aa)
	CNBG_2656	RNA helicase. (1666 aa)
	CNBG_4075	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (501 aa)
	CNBG_3915	Endonuclease/exonuclease/phosphatase. (351 aa)
	CNBG_5096	Alcohol dehydrogenase. (309 aa)
	CNBG_5326	D-lactaldehyde dehydrogenase. (346 aa)
	CNBG_5871	Dihydrolipoyl dehydrogenase. (511 aa)
	CNBG_9366	4-aminobutyrate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (460 aa)
	CNBG_9175	Acetyl-CoA carboxylase/biotin carboxylase. (2227 aa)
	CNBG_9139	2-oxoisovalerate dehydrogenase E1 component, beta subunit. (354 aa)

Your Current Organism:

Cryptococcus gattii

NCBI taxonomy Id: 294750
Other names: C. gattii VGII R265, Cryptococcus bacillisporus R265, Cryptococcus bacillisporus VGII R265, Cryptococcus deuterogattii R265, Cryptococcus gattii R265, Cryptococcus gattii VGII R265, Cryptococcus neoformans R265

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNBG_0175	CNBG_1185	A0A095C0W0	A0A095C427	SET domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.575
CNBG_0175	CNBG_1822	A0A095C0W0	A0A095C8M3	SET domain-containing protein.	Uncharacterized protein.	0.437
CNBG_0175	CNBG_2231	A0A095C0W0	A0A095EG98	SET domain-containing protein.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.483
CNBG_0261	CNBG_0646	A0A095EA30	A0A095EB87	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylmalonate-semialdehyde dehydrogenase (Acylating).	0.616
CNBG_0261	CNBG_0647	A0A095EA30	A0A095C4T1	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.489
CNBG_0261	CNBG_1137	A0A095EA30	A0A095C6G3	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-coenzyme A synthetase.	0.758
CNBG_0261	CNBG_1185	A0A095EA30	A0A095C427	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.477
CNBG_0261	CNBG_1428	A0A095EA30	A0A095C449	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.424
CNBG_0261	CNBG_2052	A0A095EA30	A0A095C971	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.754
CNBG_0261	CNBG_2231	A0A095EA30	A0A095EG98	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.563
CNBG_0261	CNBG_2539	A0A095EA30	A0A095D6A4	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.924
CNBG_0261	CNBG_2699	A0A095EA30	A0A095D6T3	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Methylmalonate-semialdehyde dehydrogenase (Acylating).	0.616
CNBG_0261	CNBG_3193	A0A095EA30	A0A095C9S9	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Thioredoxin reductase GliT.	0.616
CNBG_0261	CNBG_3562	A0A095EA30	A0A095CE09	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA C-acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.	0.866
CNBG_0261	CNBG_4075	A0A095EA30	A0A095ELI9	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	0.489
CNBG_0261	CNBG_4187	A0A095EA30	A0A095CC82	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Methionyl-tRNA formyltransferase; Belongs to the enoyl-CoA hydratase/isomerase family.	0.709
CNBG_0261	CNBG_5325	A0A095EA30	A0A095CH11	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Dihydrokaempferol 4-reductase.	0.615
CNBG_0261	CNBG_5326	A0A095EA30	A0A095ERM0	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	D-lactaldehyde dehydrogenase.	0.615
CNBG_0261	CNBG_9175	A0A095EA30	A0A0L6DHV7	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Acetyl-CoA carboxylase/biotin carboxylase.	0.688
CNBG_0646	CNBG_0261	A0A095EB87	A0A095EA30	Methylmalonate-semialdehyde dehydrogenase (Acylating).	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.616

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