(86 nodes) Ribosome biogenesis in eukaryotes network (Cryptococcus gattii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

Your Input:
	CNBG_3232	Uncharacterized protein. (292 aa)
	CNBG_0008	U3 small nucleolar RNA-associated protein 5. (709 aa)
	CNBG_0048	NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17). (1077 aa)
	CNBG_0495	Uncharacterized protein. (99 aa)
	CNBG_0510	Ribosome assembly protein 1. (1114 aa)
	CNBG_1290	GTPase. (637 aa)
	CNBG_1588	Nucleolar protein 58. (566 aa)
	CNBG_1723	Decapping nuclease RAI1. (386 aa)
	CNBG_0737	H/ACA ribonucleoprotein complex subunit 4. (503 aa)
	CNBG_0952	Midasin; Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits; Belongs to the midasin family. (4775 aa)
	CNBG_1845	CMGC/CK2 protein kinase; Belongs to the protein kinase superfamily. (338 aa)
	CNBG_2173	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (127 aa)
	CNBG_2458	Periodic tryptophan protein 2. (884 aa)
	CNBG_2345	18S rRNA biogenesis protein RCL1. (365 aa)
	CNBG_2683	U3 small nucleolar RNA-associated protein 10. (2001 aa)
	CNBG_1747	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (1095 aa)
	CNBG_2675	Protein KRI1. (743 aa)
	CNBG_2833	Nuclear RNA export factor 1/2. (637 aa)
	CNBG_1922	Ribonuclease III. (430 aa)
	CNBG_2102	Ribosomal RNA-processing protein 7. (404 aa)
	CNBG_3118	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (540 aa)
	CNBG_2995	Uncharacterized protein. (454 aa)
	CNBG_2217	AAA family ATPase. (763 aa)
	CNBG_3383	Nuclear GTP-binding protein. (639 aa)
	CNBG_2747	Uncharacterized protein. (461 aa)
	CNBG_4022	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (271 aa)
	CNBG_3809	Large subunit GTPase 1. (736 aa)
	CNBG_3834	Nuclear GTP-binding protein. (670 aa)
	CNBG_3487	Ribonuclease P/MRP protein subunit POP5; Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Belongs to the eukaryotic/archaeal RNase P protein component 2 family. (210 aa)
	CNBG_4081	Spindle pole body component. (869 aa)
	CNBG_4151	U3 small nucleolar ribonucleoprotein IMP4. (288 aa)
	CNBG_3771	SBDS family rRNA metabolism protein. (244 aa)
	CNBG_5093	Nucleolar protein. (476 aa)
	CNBG_4975	RNA exonuclease 1. (656 aa)
	CNBG_4995	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (666 aa)
	CNBG_5005	Serine/threonine-protein kinase RIO1; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. (621 aa)
	CNBG_5090	CK1/CK1 protein kinase. (353 aa)
	CNBG_5433	U3 small nucleolar RNA-associated protein 6. (447 aa)
	CNBG_6123	Pre-60S factor REI1. (413 aa)
	CNBG_5828	Uncharacterized protein. (186 aa)
	CNBG_5217	Uncharacterized protein. (174 aa)
	CNBG_6203	U3 small nucleolar RNA-associated protein 14. (952 aa)
	CNBG_5552	Uncharacterized protein. (592 aa)
	CNBG_6177	U3 small nucleolar RNA-associated protein 18. (624 aa)
	CNBG_0174	Uncharacterized protein. (769 aa)
	CNBG_0714	U3 small nucleolar RNA-associated protein 22. (1237 aa)
	CNBG_0729	U3 small nucleolar RNA-associated protein 21. (597 aa)
	CNBG_0879	CK1/CK1/CK1-D protein kinase; Belongs to the protein kinase superfamily. (331 aa)
	TIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export; Belongs to the eIF-6 family. (245 aa)
	CNBG_1209	Ribosome biogenesis ATPase. (763 aa)
	CNBG_2039	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (366 aa)
	CNBG_2229	Uncharacterized protein. (244 aa)
	CNBG_2789	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (159 aa)
	CNBG_2804	Rieske domain-containing protein. (514 aa)
	CNBG_3674	RNA exonuclease 1. (534 aa)
	CNBG_3738	rRNA 2'-O-methyltransferase fibrillarin. (314 aa)
	CNBG_3818	tRNA pseudouridine(55) synthase. (446 aa)
	CNBG_4589	U3 small nucleolar RNA-associated protein 12. (988 aa)
	NAT10	RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (724 aa)
	CNBG_5319	Uncharacterized protein. (868 aa)
	CNBG_5349	Nucleolar protein 56. (571 aa)
	CNBG_5404	U3 small nucleolar ribonucleoprotein protein MPP10; Involved in nucleolar processing of pre-18S ribosomal RNA. Belongs to the MPP10 family. (776 aa)
	CNBG_5534	Uncharacterized protein. (69 aa)
	CNBG_0281	Oligoribonuclease. (214 aa)
	CNBG_0626	H/ACA ribonucleoprotein complex subunit 3. (103 aa)
	CNBG_0836	Uncharacterized protein. (444 aa)
	CNBG_1076	U3 small nucleolar ribonucleoprotein IMP3. (182 aa)
	CNBG_1156	U3 small nucleolar RNA-associated protein 15. (523 aa)
	CNBG_1461	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family. (493 aa)
	CNBG_2191	Exportin-1. (1104 aa)
	CNBG_2611	Ribonuclease P/MRP protein subunit POP1. (779 aa)
	CNBG_3026	Ribonuclease P protein subunit POP4. (357 aa)
	CNBG_3046	Bromodomain-containing factor 1. (767 aa)
	CNBG_3256	Ribosome biogenesis protein BMS1. (1139 aa)
	CNBG_3661	NTF2 domain-containing protein. (178 aa)
	CNBG_3970	GTP-binding nuclear protein; GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle. Belongs to the small GTPase superfamily. Ran family. (211 aa)
	CNBG_4085	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (225 aa)
	CNBG_4276	Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (196 aa)
	CNBG_4516	FHA domain-containing protein. (799 aa)
	CNBG_4746	Uncharacterized protein. (582 aa)
	CNBG_4991	Nucleolar protein 4. (980 aa)
	CNBG_5306	U3 small nucleolar RNA-associated protein 24. (181 aa)
	CNBG_5611	Nucleolar essential protein 1. (330 aa)
	CNBG_5856	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (724 aa)
	CNBG_9358	Uncharacterized protein. (358 aa)
	CNBG_9383	U3 small nucleolar RNA-associated protein 13. (903 aa)

Your Current Organism:

Cryptococcus gattii

NCBI taxonomy Id: 294750
Other names: C. gattii VGII R265, Cryptococcus bacillisporus R265, Cryptococcus bacillisporus VGII R265, Cryptococcus deuterogattii R265, Cryptococcus gattii R265, Cryptococcus gattii VGII R265, Cryptococcus neoformans R265

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNBG_0008	CNBG_0048	A0A095BZG5	A0A095BZK4	U3 small nucleolar RNA-associated protein 5.	NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17).	0.999
CNBG_0008	CNBG_0714	A0A095BZG5	A0A095D039	U3 small nucleolar RNA-associated protein 5.	U3 small nucleolar RNA-associated protein 22.	0.998
CNBG_0008	CNBG_0729	A0A095BZG5	A0A095D057	U3 small nucleolar RNA-associated protein 5.	U3 small nucleolar RNA-associated protein 21.	0.999
CNBG_0008	CNBG_0737	A0A095BZG5	A0A095C550	U3 small nucleolar RNA-associated protein 5.	H/ACA ribonucleoprotein complex subunit 4.	0.604
CNBG_0008	CNBG_1076	A0A095BZG5	A0A095ECM3	U3 small nucleolar RNA-associated protein 5.	U3 small nucleolar ribonucleoprotein IMP3.	0.996
CNBG_0008	CNBG_1156	A0A095BZG5	A0A095ECW3	U3 small nucleolar RNA-associated protein 5.	U3 small nucleolar RNA-associated protein 15.	0.999
CNBG_0008	CNBG_1209	A0A095BZG5	A0A095D1Q1	U3 small nucleolar RNA-associated protein 5.	Ribosome biogenesis ATPase.	0.612
CNBG_0008	CNBG_1290	A0A095BZG5	A0A095C4D6	U3 small nucleolar RNA-associated protein 5.	GTPase.	0.568
CNBG_0008	CNBG_1461	A0A095BZG5	A0A095EDW3	U3 small nucleolar RNA-associated protein 5.	20S-pre-rRNA D-site endonuclease NOB1; Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm. Belongs to the NOB1 family.	0.747
CNBG_0008	CNBG_1588	A0A095BZG5	A0A095C4K0	U3 small nucleolar RNA-associated protein 5.	Nucleolar protein 58.	0.999
CNBG_0008	CNBG_1747	A0A095BZG5	A0A095C8E0	U3 small nucleolar RNA-associated protein 5.	5'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.	0.686
CNBG_0008	CNBG_2102	A0A095BZG5	A0A095C9C2	U3 small nucleolar RNA-associated protein 5.	Ribosomal RNA-processing protein 7.	0.993
CNBG_0008	CNBG_2173	A0A095BZG5	A0A095C6E2	U3 small nucleolar RNA-associated protein 5.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.988
CNBG_0008	CNBG_2345	A0A095BZG5	A0A095C7L5	U3 small nucleolar RNA-associated protein 5.	18S rRNA biogenesis protein RCL1.	0.997
CNBG_0008	CNBG_2458	A0A095BZG5	A0A095C7H2	U3 small nucleolar RNA-associated protein 5.	Periodic tryptophan protein 2.	0.999
CNBG_0008	CNBG_2675	A0A095BZG5	A0A095C8L3	U3 small nucleolar RNA-associated protein 5.	Protein KRI1.	0.475
CNBG_0008	CNBG_2683	A0A095BZG5	A0A095C834	U3 small nucleolar RNA-associated protein 5.	U3 small nucleolar RNA-associated protein 10.	0.999
CNBG_0008	CNBG_2789	A0A095BZG5	A0A095D740	U3 small nucleolar RNA-associated protein 5.	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.	0.646
CNBG_0008	CNBG_2995	A0A095BZG5	A0A095C9P3	U3 small nucleolar RNA-associated protein 5.	Uncharacterized protein.	0.475
CNBG_0008	CNBG_3026	A0A095BZG5	A0A095EIV7	U3 small nucleolar RNA-associated protein 5.	Ribonuclease P protein subunit POP4.	0.402

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