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pepT pepT sdaA sdaA cysK_2 cysK_2 cysM cysM cysA cysA cysW cysW cysT cysT pepB pepB metN metN metI metI metQ metQ rcsF rcsF yaeB yaeB pepP pepP serA2 serA2 metK metK gshB gshB metC_2 metC_2 metH metH metA metA metE metE metF metF metC1 metC1 sbp sbp cysE cysE metC_1 metC_1 glpE glpE carP carP serB serB mtnN mtnN cysJ cysJ cysI cysI cysH cysH cysD cysD cysN cysN cysC cysC gshA gshA luxS luxS pepD pepD cysK_1 cysK_1 cysS cysS sseA sseA metB metB uptG uptG sdaB sdaB sdaC sdaC serC serC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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pepTPeptidase T; Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (423 aa)
sdaASerine dehydratase; Catalyzes the formation of pyruvate from serine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (454 aa)
cysK_2Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (322 aa)
cysMCysteine synthase; Catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (293 aa)
cysASulfate/thiosulfate transporter subunit; Part of the ABC transporter complex CysAWTP involved in sulfate/thiosulfate import. Responsible for energy coupling to the transport system. (364 aa)
cysWPart of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
cysTSulfate/thiosulfate transporter subunit; Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import; Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily. (277 aa)
pepBAminopeptidase B; Probably plays an important role in intracellular peptide degradation. (431 aa)
metNDL-methionine transporter ATP-binding subunit; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (343 aa)
metIDL-methionine transporter permease subunit; Part of the MetNIQ methionine uptake system; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
metQDL-methionine transporter substrate-binding subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nlpA lipoprotein family. (271 aa)
rcsFMembrane protein; Essential component of the Rcs signaling system, which controls transcription of numerous genes. Plays a role in signal transduction from the cell surface to the histidine kinase RcsC. May detect outer membrane defects; Belongs to the RcsF family. (136 aa)
yaeBtRNA (adenine(37)-N6)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
pepPProline aminopeptidase P II; Exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; Derived by automated computational analysis using gene prediction method: Protein Homology. (437 aa)
serA2D-3-phosphoglycerate dehydrogenase; Catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (413 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (384 aa)
gshBCatalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic GSH synthase family. (319 aa)
metC_2Cystathionine beta-lyase; Catalyzes the formation of L-homocysteine from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
metHB12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1236 aa)
metAHomoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. (309 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (763 aa)
metFMTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (294 aa)
metC1Catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
sbpSulfate transporter subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
cysECatalyzes the O-acetylation of serine; Derived by automated computational analysis using gene prediction method: Protein Homology. (273 aa)
metC_1Cystathionine beta-lyase; Catalyzes the formation of L-homocysteine from cystathionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
glpEThiosulfate sulfurtransferase; Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide. (109 aa)
carPMultifunctional aminopeptidase A; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (503 aa)
serBPhosphoserine phosphatase; Catalyzes the formation of serine from O-phosphoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
mtnN5'-methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/U [...] (233 aa)
cysJSulfite reductase subunit alpha; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. Belongs to the NADPH-dependent sulphite reductase flavoprotein subunit CysJ family. In the N-terminal section; belongs to the flavodoxin family. (600 aa)
cysISulfite reductase subunit beta; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (571 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (249 aa)
cysDSulfate adenylyltransferase subunit 2; With CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
cysNSulfate adenylyltransferase subunit 1; May be the GTPase, regulating ATP sulfurylase activity. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (481 aa)
cysCAdenylylsulfate kinase; Catalyzes the synthesis of activated sulfate. (213 aa)
gshAGlutamate--cysteine ligase; Involved in the first step of glutathione biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (519 aa)
luxSS-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)
pepDAminoacyl-histidine dipeptidase; Catalyzes the hydrolysis of Xaa-His dipeptides; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)
cysK_1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (346 aa)
cysScysteine--tRNA ligase; Catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (463 aa)
sseA3-mercaptopyruvate sulfurtransferase; Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
metBCystathionine beta-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
uptGCystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
sdaBSerine dehydratase; Catalyzes the formation of pyruvate from serine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (455 aa)
sdaCSerine/threonine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (361 aa)
Your Current Organism:
Yersinia ruckeri
NCBI taxonomy Id: 29486
Other names: ATCC 29473, CCM 6093, CCUG 14190, CDC 2396-61, CIP 82.80, DSM 18506, JCM 15110, JCM 2429, NCIB 2194, NCIMB 2194, NCTC 12986, Y. ruckeri
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