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glcA glcA bglX1 bglX1 nagK nagK bglA bglA cutC cutC yeaD yeaD manA manA mlc_1 mlc_1 anmK anmK yniC yniC ampC ampC chbG chbG celD celD chbA chbA gmuD gmuD chbC chbC celA celA AKA37517.1 AKA37517.1 mtfA mtfA fruA fruA fruK fruK fpr_2 fpr_2 hpr hpr ptsI_2 ptsI_2 crr crr nanT nanT AKA37875.1 AKA37875.1 nanK nanK nanE nanE dapA1 dapA1 murP murP murQ murQ murR murR ptsP ptsP srlA srlA srlE srlE AKA38231.1 AKA38231.1 AKA38232.1 AKA38232.1 AKA38233.1 AKA38233.1 srlR srlR fruK_1 fruK_1 yhbH yhbH ptsN ptsN yhbJ yhbJ npr npr treA treA treB treB treR treR ChiY_3 ChiY_3 glmU glmU glmS glmS mtlA mtlA mtlD2 mtlD2 chbF chbF glmM glmM gldA gldA dhaK dhaK dhaL dhaL dhaM dhaM dhaR dhaR ampD ampD mak mak malZ malZ ampG ampG nagD nagD mlc_2 mlc_2 nagA nagA nagB nagB nagE nagE chb chb
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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glcAPTS glucose-specific subunit IIBC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
bglX1Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (343 aa)
nagKN-acetylglucosamine kinase; Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. (306 aa)
bglAaryl-phospho-beta-D-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 1 family. (478 aa)
cutCCopper homeostasis protein CutC; Participates in the control of copper homeostasis. Belongs to the CutC family. (252 aa)
yeaDGlucose-6-phosphate 1-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glucose-6-phosphate 1-epimerase family. (291 aa)
manAMannose-6-phosphate isomerase; Catalyzes the formation of of fructose 6-phosphate from mannose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannose-6-phosphate isomerase type 1 family. (391 aa)
mlc_1Transcriptional regulator; Mlc, controls the expression of genes involved in the phosphotransferase and phosphoenolpyruvate systems, regulates genes involved in the uptake of sugars; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (370 aa)
yniC2-deoxyglucose-6-phosphatase; YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
ampCBeta-lactamase; Derived by automated computational analysis using gene prediction method: Protein Homology. (381 aa)
chbGHypothetical protein; Involved in the degradation of chitin. ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, t [...] (253 aa)
celDTranscriptional regulator; Represses the celABCDF-ydjC operon involved in carbon uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
chbAPTS system N,N'-diacetylchitobiose-specific transporter subunit IIA; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. (115 aa)
gmuD6-phospho-beta-glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycosyl hydrolase 1 family. (461 aa)
chbCPTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (453 aa)
celAPTS system N,N'-diacetylchitobiose-specific transporter subunit IIB; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
AKA37517.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (134 aa)
mtfADgsA anti-repressor MtfA; Involved in the regulation of ptsG expression by binding and inactivating Mlc. (260 aa)
fruAPTS system fructose-specific transporter subunits IIBC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (558 aa)
fruK1-phosphofructokinase; Converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (312 aa)
fpr_2Bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HPr which then transfers the phosphoryl group to the IIB component; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
hprPTS sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
ptsI_2Phosphoenolpyruvate-protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (575 aa)
crrPTS system glucose-specific transporter subunit IIA; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (169 aa)
nanTSialic acid transporter; Catalyzes the proton-dependent transport of sialic acid. Belongs to the major facilitator superfamily. Sialate:H(+) symporter (SHS) (TC 2.A.1.12) family. (496 aa)
AKA37875.1Sugar isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
nanKN-acetylmannosamine kinase; Catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
nanEN-acetylmannosamine-6-phosphate 2-epimerase; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (199 aa)
dapA1N-acetylneuraminate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
murPPTS sugar transporter subunit IIC; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
murQN-acetylmuramic acid-6-phosphate etherase; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily. (295 aa)
murRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
ptsPPhosphoenolpyruvate-protein phosphotransferase; Member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (748 aa)
srlAPTS system glucitol/sorbitol-specific transporter subunit IIC; Catalyzes the phosphorylation of incoming sugar substrates along with their translocation across the cell membrane; the IIC domain forms the PTS system translocation channel and contains the specific substrate-binding site; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)
srlEPTS system glucitol/sorbitol-specific transporter subunit IIB; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; subunit IIB transfers the phosphoryl group to the substrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (321 aa)
AKA38231.1PTS system glucitol/sorbitol-specific transporter subunit IIA; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)
AKA38232.1Sorbitol-6-phosphate 2-dehydrogenase; Catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
AKA38233.1Regulator for glucitol utilization; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
srlRTranscriptional regulator; Regulates genes involved in glucitol utilization; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
fruK_16-phosphofructokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (310 aa)
yhbHRibosome hibernation promoting factor HPF; YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
ptsNPTS system nitrogen regulatory protein IIA(Ntr); Involved in nitrogen metabolism; protein IIA is phosphorylated by enzyme I(Ntr); Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
yhbJglmZ(sRNA)-inactivating NTPase; Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6- phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS; Belongs to the RapZ-like family. RapZ subfamily. (283 aa)
nprPhosphohistidinoprotein-hexose phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (90 aa)
treATrehalose-6-phosphate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (552 aa)
treBPTS system trehalose(maltose)-specific transporter subunits IIBC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
treRRegulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
ChiY_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (808 aa)
glmUGlucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa)
glmSGlucosamine--fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (609 aa)
mtlAPTS system mannitol-specific transporter subunit IICBA; Catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; subunit IIC forms the translocation channel and contains the specific substrate-binding site; subunit IIA is phosphorylated and transfers the phosphoryl group to the IIB subunit; subunit IIB transfers the phosphoryl group to the substrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (644 aa)
mtlD2Mannitol-1-phosphate 5-dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
chbFDiacetylchitobiose-6-phosphate hydrolase; Catalyzes the fromation of N-acetyl-D-glucosamine and N-acetyl-D-glucosamine-6-phosphate from diacetylchitobiose-6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (446 aa)
gldAGlycerol dehydrogenase; Forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
dhaKWith DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
dhaLDihydroxyacetone kinase; With DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; Derived by automated computational analysis using gene prediction method: Protein Homology. (210 aa)
dhaMDihydroxyacetone kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
dhaRTranscriptional regulator; Positively regulates the dhaKLM operon from a sigma-70 promoter; Derived by automated computational analysis using gene prediction method: Protein Homology. (630 aa)
ampDN-acetyl-anhydromuranmyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
makFructokinase; Catalyzes phosphorylation of fructose; cytosolic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
malZMaltodextrin glucosidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (609 aa)
ampGMuropeptide transporter; In Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (492 aa)
nagDUMP phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
mlc_2Transcriptional regulator; Regulates the synthesis of glucosamine and N-acetylglucosamine by acting as a repressor of the nagEBACD operon and both a repressor and activator of the glmSU operon; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
nagAN-acetylglucosamine-6-phosphate deacetylase; Catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
nagBGlucosamine-6-phosphate deaminase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (266 aa)
nagEPTS N-acetyl glucosamine transporter subunits IIABC; Phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; Derived by automated computational analysis using gene prediction method: Protein Homology. (676 aa)
chbbeta-N-acetylhexosaminidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (893 aa)
Your Current Organism:
Yersinia ruckeri
NCBI taxonomy Id: 29486
Other names: ATCC 29473, CCM 6093, CCUG 14190, CDC 2396-61, CIP 82.80, DSM 18506, JCM 15110, JCM 2429, NCIB 2194, NCIMB 2194, NCTC 12986, Y. ruckeri
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